Role of Protein Kinase C in Hydroxyapatite- induced Phagocytosis by a Murine Macrophage Cell Line (RAW264.7)

2006 ◽  
Vol 28 (3) ◽  
pp. 485-489
Author(s):  
V.K. Gopinath ◽  
M. Musa ◽  
A.R. Samsudin ◽  
W. Sosroseno
1998 ◽  
Vol 273 (49) ◽  
pp. 32787-32792 ◽  
Author(s):  
Anik St-Denis ◽  
Frédéric Chano ◽  
Pierre Tremblay ◽  
Yves St-Pierre ◽  
Albert Descoteaux

1995 ◽  
Vol 8 (3) ◽  
pp. 135-149
Author(s):  
N. Vallot ◽  
F. Boudard ◽  
M. Bastide

The mechanism of action of pichilan, a (1->3)-β-D-glucan on nitric oxide production by a murine macrophage cell line, MALU cells, was examined. Different metabolic pathways were investigated in order to understand pichilan-induced NO secretion. We demonstrate in the present paper that neither the acid arachidonic metabolism, the cAMP nor Ca2+ accumulation occured in the pichilan mechanism of action on NO secretion. On the other hand, we observed that a phorbol ester, PMA, modulated the NO secretion. An inhibition of 36% of the NO secretion was observed; consequently, pichilan could regulate the NO secretion by way of the protein kinase C. Furthermore, we demonstrated that TNF production stimulated by pichilan activation induced NO secretion by MALU cells. TNF would be the main modulator of NO secretion by pichilan or LPS-activated MALU cells. Moreover, we can note that pichilan and LPS did not act similarly on nitrite secretion by MALU cells.


2006 ◽  
Vol 51 (4) ◽  
pp. 339-344 ◽  
Author(s):  
V.K. Gopinath ◽  
M. Musa ◽  
A.R. Samsudin ◽  
P. Lalitha ◽  
W. Sosroseno

Cytokine ◽  
2000 ◽  
Vol 12 (3) ◽  
pp. 207-219 ◽  
Author(s):  
Masaya Ueno ◽  
Yoshiko Sonoda ◽  
Megumi Funakoshi ◽  
Naofumi Mukaida ◽  
Kiyoshi Nose ◽  
...  

1998 ◽  
Vol 350 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Nalini Kaul ◽  
Rayudu Gopalakrishna ◽  
Usha Gundimeda ◽  
Jinah Choi ◽  
Henry Jay Forman

Sign in / Sign up

Export Citation Format

Share Document