Risk Factors for Post-Transplant Death in Donation after Circulatory Death Liver Transplantation

2017 ◽  
Vol 31 (5) ◽  
pp. 393-401
Author(s):  
Song Liu ◽  
Ji Miao ◽  
Xiaolei Shi ◽  
Yafu Wu ◽  
Chunping Jiang ◽  
...  
2020 ◽  
Vol 86 (2) ◽  
Author(s):  
Chiara Lazzeri ◽  
Manuela Bonizzoli ◽  
Fabio Marra ◽  
Paolo Muiesan ◽  
Davide Ghinolfi ◽  
...  

JAMA Surgery ◽  
2014 ◽  
Vol 149 (1) ◽  
pp. 77 ◽  
Author(s):  
Johnny C. Hong ◽  
Robert Venick ◽  
Hasan Yersiz ◽  
Prawat Kositamongkol ◽  
Fady M. Kaldas ◽  
...  

2018 ◽  
Vol 22 (2) ◽  
pp. 229-236 ◽  
Author(s):  
James M. West

Anesthesiologists have clearly established their place in the history of medical ethics. Our involvement goes back to 1966 when Henri Beecher published his landmark paper on research and informed consent. Participation in the ethics of transplantation is no less important than our previous work. Organ transplant has been life saving for many but also has given rise to many misunderstandings not just from the public but also among our own colleagues. These include methods of allocation and donation, the role that affluence may play in receiving an organ, the definition of death and donation after circulatory death. As perioperative physicians and important members of the transplant team, anesthesiologists are expected to participate in all aspects of care including ethical judgments. This article discusses some of the issues that seem to cause the most confusion and angst for those of us involved in both liver transplantation and in the procurement of organs. It will discuss the definition of death, donation after circulatory death, the anesthesiologists’ role on the selection committee, living donor liver transplantation, and transplantation of patients with alcohol-related liver disease.


2020 ◽  
Vol 272 (5) ◽  
pp. 759-765
Author(s):  
Matteo Mueller ◽  
Marit Kalisvaart ◽  
Joanne O‘Rourke ◽  
Shishir Shetty ◽  
Alessandro Parente ◽  
...  

2020 ◽  
Vol 40 (03) ◽  
pp. 256-263
Author(s):  
Kristopher P. Croome

AbstractDonation after circulatory death (DCD) donors represent a potential means to help address the disparity between the number of patients awaiting liver transplantation (LT) and the availability of donor livers. While initial enthusiasm for DCD LT was high in the early 2000s, early reports of high rates of biliary complications and inferior graft survival resulted in reluctance among many transplant centers to use DCD liver grafts. As with all innovations in transplant practice, there is undoubtedly a learning curve associated with the optimal utilization of liver grafts from DCD donors. More contemporary data has demonstrated that results with DCD LT are improving and the number of DCD LT performed annually has been steadily increasing. In this concise review, potential mechanisms of injury for DCD livers are discussed along with strategies that have been employed in clinical practice to improve DCD LT outcomes.


2019 ◽  
Vol 19 (11) ◽  
Author(s):  
M. Leemkuil ◽  
H. G. D. Leuvenink ◽  
R. A. Pol

Abstract Purpose of Review Beta-cell replacement is the best therapeutic option for patients with type 1 diabetes. Because of donor scarcity, more extended criteria donors are used for transplantation. Donation after circulatory death donors (DCD) are not commonly used for pancreas transplantation, because of the supposed higher risk of complications. This review gives an overview on the pathophysiology, risk factors, and outcome in DCD transplantation and discusses different preservation methods. Recent Findings Studies on outcomes of DCD pancreata show similar results compared with those of donation after brain death (DBD), when accumulation of other risk factors is avoided. Hypothermic machine perfusion is shown to be a safe method to improve graft viability in experimental settings. Summary DCD should not be the sole reason to decline a pancreas for transplantation. Adequate donor selection and improved preservation techniques can lead to enhanced pancreas utilization and outcome.


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