A bilayer composite composed of TiO2-incorporated electrospun chitosan membrane and human extracellular matrix sheet as a wound dressing

2015 ◽  
Vol 26 (13) ◽  
pp. 841-854 ◽  
Author(s):  
Chang Hee Woo ◽  
Young Chan Choi ◽  
Ji Suk Choi ◽  
Hee Young Lee ◽  
Yong Woo Cho
Keyword(s):  
Extracellular Matrix ◽  
Wound Dressing ◽  
Chitosan Membrane

Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing

Biomaterials ◽  
2001 ◽  
Vol 22 (2) ◽  
pp. 165-173 ◽  
Author(s):  
Fwu-Long Mi ◽  
Shin-Shing Shyu ◽  
Yu-Bey Wu ◽  
Sung-Tao Lee ◽  
Jen-Yeu Shyong ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Chitosan Membrane ◽  
Fabrication And Characterization

scholarly journals Preparation of Nanofibers with Renewable Polymers and Their Application in Wound Dressing

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Ying Zhao ◽  
Yihui Qiu ◽  
Huanhuan Wang ◽  
Yu Chen ◽  
Shaohua Jin ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Cell Adhesion ◽  
Specific Surface ◽  
Wound Dressing ◽  
Recent Progress ◽  
High Specific Surface Area ◽  
High Porosity ◽  
Renewable Polymers ◽  
Good Biocompatibility

Renewable polymers have attracted considerable attentions in the last two decades, predominantly due to their environmentally friendly properties, renewability, good biocompatibility, biodegradability, bioactivity, and modifiability. The nanofibers prepared from the renewable polymers can combine the excellent properties of the renewable polymer and nanofiber, such as high specific surface area, high porosity, excellent performances in cell adhesion, migration, proliferation, differentiation, and the analogous physical properties of extracellular matrix. They have been widely used in the fields of wound dressing to promote the wound healing, hemostasis, skin regeneration, and treatment of diabetic ulcers. In the present review, the different methods to prepare the nanofibers from the renewable polymers were introduced. Then the recent progress on preparation and properties of the nanofibers from different renewable polymers or their composites were reviewed; the application of them in the fields of wound dressing was emphasized.

Preparation of polyvinyl alcohol/asiaticoside/chitosan membrane nano-composite using electrospinning technique for wound dressing

2020 ◽  
Author(s):  
Arifin Budi Raharjo ◽  
Richo Dwi Andika Putra ◽  
Nanik Indayaningsih ◽  
Yudi Srifiana ◽  
Andri Hardiansyah ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Electrospinning Technique ◽  
Nano Composite ◽  
Chitosan Membrane

scholarly journals Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Héctor Capella-Monsonís ◽  
Andrea De Pieri ◽  
Rita Peixoto ◽  
Stefanie Korntner ◽  
Dimitrios I. Zeugolis
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Wound Dressing ◽  
Collagen Scaffold ◽  
Cell Delivery ◽  
Adipose Derived Stem Cells ◽  
Stem Cell Delivery ◽  
Delivery Vehicles ◽  
Tissue Grafts ◽  
Adipose Derived Stem Cell

Abstract Background Stem cell therapies represent a promising tool in regenerative medicine. Considering the drawbacks of direct stem cell injections (e.g. poor cell localisation), extracellular matrix-based biomaterials (e.g. scaffolds and tissue grafts), due to their compositional biofunctionality and cytocompatibility, are under investigation as potential stem cell carriers. Methods The present study assessed the potential of three commercially available extracellular matrix-based biomaterials [a collagen/glycosaminoglycan scaffold (Integra™ Matrix Wound Dressing), a decellularised porcine peritoneum (XenoMEM™) and a porcine urinary bladder (MatriStem™)] as human adipose-derived stem cell delivery vehicles. Results Both tissue grafts induced significantly (p < 0.01) higher human adipose-derived stem cell proliferation in vitro over the collagen scaffold, especially when the cells were seeded on the basement membrane side. Human adipose-derived stem cell phenotype and trilineage differentiation potential was preserved in all biomaterials. In a splinted wound healing nude mouse model, in comparison to sham, biomaterials alone and cells alone groups, all biomaterials seeded with human adipose-derived stem cells showed a moderate improvement of wound closure, a significantly (p < 0.05) lower wound gap and scar index and a significantly (p < 0.05) higher proportion of mature collagen deposition and angiogenesis (the highest, p < 0.01, was observed for the cell loaded at the basement membrane XenoMEM™ group). All cell-loaded biomaterial groups retained more cells at the implantation side than the direct injection group, even though they were loaded with half of the cells than the cell injection group. Conclusions This study further advocates the use of extracellular matrix-based biomaterials (in particular porcine peritoneum) as human adipose-derived stem cell delivery vehicles. Graphical abstract Comparative analysis of a collagen scaffold (Integra™ Matrix Wound Dressing) and two tissue grafts [decellularised porcine peritoneum (XenoMEM™) and porcine urinary bladder (MatriStem™)] as human adipose-derived stem cells carriers

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