To understand the effect of a single overload on the fracture behavior in welded joints, the stress and strain field at the crack tip in a safe-end dissimilar metal welded joint in nuclear pressure vessel is simulated and analyzed by using the elastic-plastic finite element method in the paper, in which the mechanical heterogeneity in welded joint is emphatically considered. The investigating results indicate that the tensile plastic strain at crack tip increases, but the tensile stress decreases as a single overload increases, and the influence of a single overload on tensile strain is larger than one on tensile stress, which provide a theoretical basis for quantitatively estimating the crack growth rate of environmentally assisted cracking in the welded structural material of pressure vessel and piping in the nuclear power plant.