Does high serum progesterone level on the day of human chorionic gonadotropin administration affect pregnancy rate after intracytoplasmic sperm injection and embryo transfer?

2008 ◽  
Vol 24 (7) ◽  
pp. 368-372 ◽  
Author(s):  
Foad Azem ◽  
Joseph B. Lessing ◽  
Mira Malcov ◽  
Dalit Ben-Yosef ◽  
Beni Almog ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Intracytoplasmic Sperm Injection ◽  
High Serum ◽  
Progesterone Level ◽  
Serum Progesterone

scholarly journals The impact of late follicular progesterone level on in vitro fertilization-intracytoplasmic sperm injection outcome: Case-control study

2020 ◽  
Author(s):  
Diana Novia ◽  
Hilma Putri Lubis ◽  
Binarwan Halim ◽  
Anantya Pustimbara ◽  
Retno Lestari ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Intracytoplasmic Sperm Injection ◽  
Case Control ◽  
Progesterone Level ◽  
Serum Progesterone ◽  
Vitro Fertilization ◽  
The Impact

Background: Studies have been conducted to improve the pregnancy rate through the in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) program. In recent years, researchers have been focusing on finding impact of high progesterone level on endometrial receptivity. However, data on whether progesterone level also affects the quality of the embryo is still limited. Objective: The aim is to assess the effect of late follicular progesterone level on the outcome of in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI). Materials and Methods: This was a case-control of 245 women who underwent in vitro fertilization cycle at Halim Fertility Center, Indonesia. The outcomes assessed were number of oocytes retrieved (OR), maturation rate (MR), fertilization rate (FR), number of good embryos (GE), number of fair embryos (FE), and number of poor embryos (PE). The progesterone (P4) and estradiol (E2) levels were analyzed on the day of human chorionic gonadotropin injection. Serum progesterone level was divided into three groups: 1. low progesterone (≤ 0.50 ng/ml), 2. normal progesterone (0.51-1.50 ng/ml), and 3. high progesterone (> 1.50 ng/ml). All outcomes were compared amongst the groups. Results: Significant differences occurred between progesterone level on the day of human chorionic gonadotropin administration. The number of OR in group 1, 2, and 3 were 8.41 ± 5.88 vs. 12.99 ± 8.51 vs. 17.58 ± 9.52, respectively. Conclusion: Progesterone level on the day of human chorionic gonadotropin injection may have an impact on the outcome of IVF-ICSI. Key words: Intracytoplasmic sperm injection, Embryo, Progesterone, In vitro fertilization.

scholarly journals Evaluation of the relationship between serum estradiol levels on human chorionic gonadotropin administration day and intracytoplasmic sperm injection outcomes: A retrospective population-based study

2021 ◽  
Author(s):  
Masoumeh Hajshafiha ◽  
Sima Oshnouei ◽  
Mahdieh Mostafavi ◽  
Sina Dindarian ◽  
Nazila Kiarang ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Intracytoplasmic Sperm Injection ◽  
Controlled Ovarian Hyperstimulation ◽  
Population Based ◽  
Abortion Rate ◽  
Optimum Number ◽  
Vitro Fertilization

Background: The correlation between high estradiol (E2) levels induced by controlled ovarian hyperstimulation (COH) and pregnancy is controversial. Objective: To assess the effect of serum E2 levels on the day of human chorionic gonadotropin administration on the intracytoplasmic sperm injection (ICSI) outcome. Materials and Methods: The current study included 551 participants who had undergone ICSI between May 2014 and May 2016. Based on E2 levels, the individuals aged < 37 yr (n = 502) and 37-42 yr (n = 49) were categorized into six and three groups, respectively. ICSI outcomes including the number of retrieved oocytes (NRO), number of embryos (NE), pregnancy rate, and abortion rate were analyzed in both groups. Results: Among participants aged < 37 yr, the NRO and NE were 8.69 ± 3.82 and 5.24 ± 2.32, respectively and they had a significant correlation with the E2 level on human chorionic gonadotropin administration day (p < 0.001 for both). Among participants aged > 37 yr, NRO and NE were 5.18 ± 3.17 and 3.40 ± 2.23, respectively, and the NRO (p < 0.001), NE (p < 0.001), pregnancy rate (p < 0.001), abortion rate (p = 0.007), and the number of grade A and B embryos (p = 0.003) had a significant association with the E2 level. Conclusion: COH is a costly procedure that may have negative effects on endometrial receptivity. Thus, in order to prevent these effects and also to reduce the costs of COH, we recommend gaining optimum number of oocytes rather than maximum number during the procedure. Key words: Intracytoplasmic sperm injection, In vitro fertilization, Estradiol, Pregnancy.

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