Against Neo-Cartesianism: Neurofunctional Resilience and Animal Pain

2021 ◽  
pp. 1-28
Author(s):  
Phil Halper ◽  
Kenneth Williford ◽  
David Rudrauf ◽  
Perry N. Fuchs
Keyword(s):  
2021 ◽  
Vol 5 (1) ◽  
pp. e100135
Author(s):  
Xue Ying Zhang ◽  
Jan Vollert ◽  
Emily S Sena ◽  
Andrew SC Rice ◽  
Nadia Soliman

ObjectiveThigmotaxis is an innate predator avoidance behaviour of rodents and is enhanced when animals are under stress. It is characterised by the preference of a rodent to seek shelter, rather than expose itself to the aversive open area. The behaviour has been proposed to be a measurable construct that can address the impact of pain on rodent behaviour. This systematic review will assess whether thigmotaxis can be influenced by experimental persistent pain and attenuated by pharmacological interventions in rodents.Search strategyWe will conduct search on three electronic databases to identify studies in which thigmotaxis was used as an outcome measure contextualised to a rodent model associated with persistent pain. All studies published until the date of the search will be considered.Screening and annotationTwo independent reviewers will screen studies based on the order of (1) titles and abstracts, and (2) full texts.Data management and reportingFor meta-analysis, we will extract thigmotactic behavioural data and calculate effect sizes. Effect sizes will be combined using a random-effects model. We will assess heterogeneity and identify sources of heterogeneity. A risk-of-bias assessment will be conducted to evaluate study quality. Publication bias will be assessed using funnel plots, Egger’s regression and trim-and-fill analysis. We will also extract stimulus-evoked limb withdrawal data to assess its correlation with thigmotaxis in the same animals. The evidence obtained will provide a comprehensive understanding of the strengths and limitations of using thigmotactic outcome measure in animal pain research so that future experimental designs can be optimised. We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines and disseminate the review findings through publication and conference presentation.


1990 ◽  
Vol 18 (1_part_1) ◽  
pp. 41-50
Author(s):  
F. Barbara Orlans

Pain scales classify the severity of pain inflicted on laboratory animals from little or none up to severe. A pain scale as part of public policy serves beneficial purposes that promote animal welfare. It can be used to educate people about the two alternatives of refinement and replacement, and the need to reduce animal pain. Furthermore, a pain scale has practical applications: 1) in review procedures for animal welfare concerns; 2) in developing policies on the use of animals in education; and 3) as a basis for collecting national data on animal experimentation, so that meaningful data can be collected on trends in reduction and control in animal pain. So far, only a few countries (including Sweden, the Netherlands, Canada and New Zealand) have adopted pain scales as part of their public policy. Most countries, including the United States, have not yet done so. The history of the development and adoption of pain scales by various countries is described and the case is presented for wider adoption of a pain scale in countries not currently using one.


2021 ◽  
Author(s):  
Hugo F Miranda ◽  
Viviana Noriega ◽  
Fernando Sierralta ◽  
Ramon Sotomayor-Zarate ◽  
Juan Carlos Prieto

Abstract Opioids are among the most effective pain relievers available, however multimodal antinociception between opioids, has not been extensively studied in diverse animal pain models.In this study the pharmacological interaction of morphine with fentanyl was evaluated in different murine pain models by means of isobolographic analysis. In control animals, morphine and fentanyl produced a dose-related antinociceptive action in the murine assays and the rank of potency was: formalin hind paw phase I > formalin phase II > tail flick. Coadministration of morphine with fentanyl, in a fixed relation 1:1 of their ED50, produces a dose response in all tests and the isobologram resulted in synergism. Fentanyl was more effective than morphine which could be explained according the suggestion that opioids could be acting through other targets, with different binding capacity thru the regulation or activation of non-opioid receptors. Co-administration of morphine with fentanyl induces synergism in all murine trials, confirming the antinociceptive capacity of both opioids which would constitute a promisory idea to multimodal treatment of pain.


2019 ◽  
Vol 2 (1) ◽  
pp. 230-246
Author(s):  
J. O. Omamegbe ◽  
F. C. Nwinyi

Most animals presented for veterinary care are suffering or will suffer from some pain during restraint, clinical examination, samples collection, diagnostic imaging, parenteral drug administration or clinical procedures et cetera. The Veterinarian is ethically, morally and professionally enjoined to recognize and alleviate such pain. Although most studies on animal pain have been focused on mostly post surgical pain in dogs and cats, animals afflicted with most common external or internal, infectious and non-infectious disease conditions also suffer from pain. Identifying animals in pain alone is difficult except if a Veterinarian with a penchant for the management of pain in animals actively looks out for it in patients. The measurement of pain in animals poses even more difficulties for the Veterinarian than its identification mainly because animals are unable to communicate the locations, the temporal occurance and the severities of the pain they feel just as they don’t of other clinical manifestations. Therefore, animals in pain rely on their owners, handlers or keepers et cetera who actually don’t know how or where it hurts them to provide such details to the Veterinaruan. To complicate matters, the use of validated pain assessment scales in animals is fraught with serious limitations except to some less extent, for the visual analog and the simple descriptive scales which seem applicable in real clinic situations. A multi-modal mode of management in which opioids, non-steroidal anti-inflammatory drugs, local anesthetics, α 2 – adrenergic agonists, NDMA receptor antagonists and ketamine delivered through a variety of routes, at varied dosages and regimens, is advocated for pain management in animals. The need to regularly review the state of the patient vis-à-vis the need to modify the treatment module and regimen cannot be over emphasized when and if a clinical case is under consideration. This may involve the change of medications, the addition of more medications, the reduction in the number of medication, changes in dosages and the regimen in use from time to time. This discuss is aimed at the general Veterinary practitioner who is presented daily with different species and breeds of animals suffering from varieties of clinical conditions or which will undergo a variety of clinical procedures capable of causing pain in the course of veterinary health care delivery in diverse clinic settings.


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