Radiation induced cell loss in rat submandibular gland and its relation to gland function

2000 ◽  
Vol 76 (3) ◽  
pp. 419-429 ◽  
Author(s):  
L. J. W. Zeilstra, A. Vissink, A. W. T
Keyword(s):  
Submandibular Gland ◽  
Cell Loss ◽  
Radiation Induced ◽  
Gland Function ◽  
Rat Submandibular Gland

Protection by selenium of lead-acetate-induced alterations on rat submandibular gland function

2001 ◽  
Vol 20 (1) ◽  
pp. 28-33 ◽  
Author(s):  
M Abdollahi ◽  
N Rahmat-Jirdeh ◽  
K Soltaninejad
Keyword(s):  
Drinking Water ◽  
Submandibular Gland ◽  
Flow Rate ◽  
Lead Acetate ◽  
Membrane Integrity ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Gland Function ◽  
Rat Submandibular Gland

Pure submandibular saliva was collected intraorally by micro polyethylene cannulation of anaesthetized rats using pilocarpine as a secretagogue. Twenty-four days treatment with lead acetate 0.05% in drinking water altered salivary function. Except for flow rate that was (P <0.01) increased by lead acetate, the reminder of parameters, concentrations of total protein and calcium and the activity of N-acetyl-β-D-glucosaminidase (NAG) in submandibular secretions were decreased significantly (P< 0.01) by lead acetate. Selenium (2.5 mg 1-l) in drinking water for 24 days did not induce any significant change in saliva secretory function. Pretreatment by selenium, prevented the lead acetate-induced decrease of NAG activity and concentrations of calcium and protein (P<0.01). The increased flow rate by lead acetate was also affected by selenium pretreatment and reached the level of control. It is concluded that selenium can protect rat submandibular gland function from lead-acetate-induced adverse effects. Properties of selenium as an antioxidant, free radical scavenger and maintenance of cell membrane integrity may be possible mechanisms of its protective effects.

Restoration of morphine-induced alterations in rat submandibular gland function by N-methyl-D-aspartate agonist

2006 ◽  
Vol 57 (3) ◽  
pp. 283-294 ◽  
Author(s):  
N. Hashemi ◽  
Azadeh Mohammadirad ◽  
Zahra Bayrami ◽  
R. Khorasani ◽  
Sanaz Vosough ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Gland Function ◽  
Rat Submandibular Gland

Cytochemical Evidence for Presynatic β-Adrenergic Regulation of Secretion in the Developing Rat Submandibular Gland

1977 ◽  
Vol 35 ◽  
pp. 430-431
Author(s):  
L.S. Cutler
Keyword(s):  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Submandibular Gland ◽  
Neonatal Rat ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Parotid Glands ◽  
Adrenergic Agonist ◽  
Rat Submandibular Gland

Many studies previously have shown that the B-adrenergic agonist isoproterenol and the a-adrenergic agonist norepinephrine will stimulate secretion by the adult rat submandibular (SMG) and parotid glands. Recent data from several laboratories indicates that adrenergic agonists bind to specific receptors on the secretory cell surface and stimulate membrane associated adenylate cyclase activity which generates cyclic AMP. The production of cyclic AMP apparently initiates a cascade of events which culminates in exocytosis. During recent studies in our laboratory it was observed that the adenylate cyclase activity in plasma membrane fractions derived from the prenatal and early neonatal rat submandibular gland was retractile to stimulation by isoproterenol but was stimulated by norepinephrine. In addition, in vitro secretion studies indicated that these prenatal and neonatal glands would not secrete peroxidase in response to isoproterenol but would secrete in response to norepinephrine. In contrast to these in vitro observations, it has been shown that the injection of isoproterenol into the living newborn rat results in secretion of peroxidase by the SMG (1).

Sign in / Sign up

Export Citation Format

Share Document