Minimal detectable change in six-minute walk test in children and adolescents with cystic fibrosis

This study explored the test-retest reliability and construct validity of a two-minute walk test in children and adolescents with CP Gross Motor Function Classification System (GMFCS) levels I, II, and III. Twenty-six participants with CP (age 11.7 ± 3.9 years) were recruited and were assessed twice with the two-minute walk test to determine the test-retest reliability (interval 2 weeks). Minimal detectable changes (MDC95) were calculated. Construct validity was established by comparing the results of the two- and six-minute walk tests during the first assessment. The test-retest reliability was excellent, with intra-class correlation (ICC) = 0.98 for all participants. The (MDC95) for all participants was 12.7 m. The distance covered by children and adolescents with CP in the two-minute walk test had high correlation (r = 0.9, p < 0.01) with distance covered in the six-minute walk test. The two-minute walk test is a valid and reliable outcome measure to assess walking performance in children and adolescents with CP. HIGHLIGHTS The two-minute walk test has excellent reliability and validity among young people with cerebral palsy The minimal detectable change of two-minute walk test among young people with cerebral palsy was 12.7 m The two-minute walk test had high correlation with the six-minute walk test among young people with cerebral palsy

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Test-Retest Reliability and Minimal Detectable Change Scores for the Timed “Up & Go” Test, the Six-Minute Walk Test, and Gait Speed in People With Alzheimer Disease

Physical Therapy ◽

10.2522/ptj.20080258 ◽

2009 ◽

Vol 89 (6) ◽

pp. 569-579 ◽

Cited By ~ 217

Author(s):

Julie D. Ries ◽

John L. Echternach ◽

Leah Nof ◽

Michelle Gagnon Blodgett

Keyword(s):

Alzheimer Disease ◽

Gait Speed ◽

Individual Variability ◽

Minimal Detectable Change ◽

Walk Test ◽

Detectable Change ◽

Retest Reliability ◽

Six Minute Walk Test ◽

Test Retest Reliability ◽

Minute Walk

Background: With the increasing incidence of Alzheimer disease (AD), determining the validity and reliability of outcome measures for people with this disease is necessary. Objective: The goals of this study were to assess test-retest reliability of data for the Timed “Up & Go” Test (TUG), the Six-Minute Walk Test (6MWT), and gait speed and to calculate minimal detectable change (MDC) scores for each outcome measure. Performance differences between groups with mild to moderate AD and moderately severe to severe AD (as determined by the Functional Assessment Staging [FAST] scale) were studied. Design: This was a prospective, nonexperimental, descriptive methodological study. Methods: Background data collected for 51 people with AD included: use of an assistive device, Mini-Mental Status Examination scores, and FAST scale scores. Each participant engaged in 2 test sessions, separated by a 30- to 60-minute rest period, which included 2 TUG trials, 1 6MWT trial, and 2 gait speed trials using a computerized gait assessment system. A specific cuing protocol was followed to achieve optimal performance during test sessions. Results: Test-retest reliability values for the TUG, the 6MWT, and gait speed were high for all participants together and for the mild to moderate AD and moderately severe to severe AD groups separately (intraclass correlation coefficients ≥.973); however, individual variability of performance also was high. Calculated MDC scores at the 90% confidence interval were: TUG=4.09 seconds, 6MWT=33.5 m (110 ft), and gait speed=9.4 cm/s. The 2 groups were significantly different in performance of clinical tests, with the participants who were more cognitively impaired being more physically and functionally impaired. Limitations: A single researcher for data collection limited sample numbers and prohibited blinding to dementia level. Conclusions: The TUG, the 6MWT, and gait speed are reliable outcome measures for use with people with AD, recognizing that individual variability of performance is high. Minimal detectable change scores at the 90% confidence interval can be used to assess change in performance over time and the impact of treatment.

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Six-minute walk test in children and adolescents with renal diseases: tolerance, reproducibility and comparison with healthy subjects

Clinics ◽

10.6061/clinics/2016(01)05 ◽

2016 ◽

Vol 71 (1) ◽

pp. 22-27 ◽

Cited By ~ 3

Author(s):

FT Watanabe ◽

VH Koch ◽

RC Juliani ◽

MT Cunha

Keyword(s):

Children And Adolescents ◽

Healthy Subjects ◽

Renal Diseases ◽

Walk Test ◽

Six Minute Walk Test ◽

Minute Walk

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Feasibility of the Six-Minute Walk Test for Patients Who Have Cystic Fibrosis, Are Ambulatory, and Require Mechanical Ventilation Before Lung Transplantation

Physical Therapy ◽

10.2522/ptj.20150235 ◽

2016 ◽

Vol 96 (9) ◽

pp. 1468-1476 ◽

Cited By ~ 5

Author(s):

Amanda L. Malamud ◽

Paul E.H. Ricard

Keyword(s):

Cystic Fibrosis ◽

Mechanical Ventilation ◽

Lung Transplantation ◽

Lung Transplant ◽

Walk Test ◽

Prolonged Intubation ◽

Six Minute Walk Test ◽

Medical Intensive Care ◽

Minute Walk ◽

United Network

Abstract Background and Purpose The Six-Minute Walk Test (6MWT) is a requirement for lung transplantation evaluation by the United Network for Organ Sharing. A subset of patients being evaluated for a lung transplantation require mechanical ventilation (MV) because of respiratory failure. The 6MWT has not been validated as an outcome measure for patients dependent on MV. Literature supports alternative forms of the 6MWT, including those with an oval track or treadmill, as valid for accommodating other populations. This case report describes the use of the 6MWT for 2 patients who had cystic fibrosis and required MV before a lung transplant. Case Description A 34-year-old woman and a 37-year-old woman were admitted to a medical intensive care unit for exacerbation of cystic fibrosis requiring prolonged intubation and a subsequent tracheostomy. Their hospital courses were characterized by participation in early rehabilitation and variable dependence on MV. Both patients performed the 6MWT for a lung transplantation workup while dependent on MV. Outcomes Both patients performed the 6MWT while using portable MV and achieved a distance greater than that required for transplantation consideration and approximately 50% of the reference-based expected distance for adults who are healthy. Confounding factors included external pacing and the use of an oval track. Discussion The use of the 6MWT for 2 patients receiving MV appeared to be feasible. Research regarding the validity of this outcome is warranted.

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