Probabilistic decision support system using machine learning techniques : A case study of Cardiovascular diseases

2021 ◽  
Vol 24 (5) ◽  
pp. 1487-1496
Author(s):  
Smita ◽  
Ela Kumar
2019 ◽  
Vol 892 ◽  
pp. 274-283
Author(s):  
Mohammed Ashikur Rahman ◽  
Afidalina Tumian

Now a day, clinical decision support systems (CDSS) are widely used in the cardiac care due to the complexity of the cardiac disease. The objective of this systematic literature review (SLR) is to identify the most common variables and machine learning techniques used to build machine learning-based clinical decision support system for cardiac care. This SLR adopts the Preferred Reporting Item for Systematic Review and Meta-Analysis (PRISMA) format. Out of 530 papers, only 21 papers met the inclusion criteria. Amongst the 22 most common variables are age, gender, heart rate, respiration rate, systolic blood pressure and medical information variables. In addition, our results have shown that Simplified Acute Physiology Score (SAPS), Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) are some of the most common assessment scales used in CDSS for cardiac care. Logistic regression and support vector machine are the most common machine learning techniques applied in CDSS to predict mortality and other cardiac diseases like sepsis, cardiac arrest, heart failure and septic shock. These variables and assessment tools can be used to build a machine learning-based CDSS.


2020 ◽  
Vol 16 (4) ◽  
pp. 407-419
Author(s):  
Aytun Onay ◽  
Melih Onay

Background: Virtual screening of candidate drug molecules using machine learning techniques plays a key role in pharmaceutical industry to design and discovery of new drugs. Computational classification methods can determine drug types according to the disease groups and distinguish approved drugs from withdrawn ones. Introduction: Classification models developed in this study can be used as a simple filter in drug modelling to eliminate potentially inappropriate molecules in the early stages. In this work, we developed a Drug Decision Support System (DDSS) to classify each drug candidate molecule as potentially drug or non-drug and to predict its disease group. Methods: Molecular descriptors were identified for the determination of a number of rules in drug molecules. They were derived using ADRIANA.Code program and Lipinski's rule of five. We used Artificial Neural Network (ANN) to classify drug molecules correctly according to the types of diseases. Closed frequent molecular structures in the form of subgraph fragments were also obtained with Gaston algorithm included in ParMol Package to find common molecular fragments for withdrawn drugs. Results: We observed that TPSA, XlogP Natoms, HDon_O and TPSA are the most distinctive features in the pool of the molecular descriptors and evaluated the performances of classifiers on all datasets and found that classification accuracies are very high on all the datasets. Neural network models achieved 84.6% and 83.3% accuracies on test sets including cardiac therapy, anti-epileptics and anti-parkinson drugs with approved and withdrawn drugs for drug classification problems. Conclusion: The experimental evaluation shows that the system is promising at determination of potential drug molecules to classify drug molecules correctly according to the types of diseases.


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