On the feasibility of pediatric dose-finding trials in small samples with information from a preceding trial in adults

Background: Suicide clusters at Cornell University and the Massachusetts Institute of Technology (MIT) prompted popular and expert speculation of suicide contagion. However, some clustering is to be expected in any random process. Aim: This work tested whether suicide clusters at these two universities differed significantly from those expected under a homogeneous Poisson process, in which suicides occur randomly and independently of one another. Method: Suicide dates were collected for MIT and Cornell for 1990–2012. The Anderson-Darling statistic was used to test the goodness-of-fit of the intervals between suicides to distribution expected under the Poisson process. Results: Suicides at MIT were consistent with the homogeneous Poisson process, while those at Cornell showed clustering inconsistent with such a process (p = .05). Conclusions: The Anderson-Darling test provides a statistically powerful means to identify suicide clustering in small samples. Practitioners can use this method to test for clustering in relevant communities. The difference in clustering behavior between the two institutions suggests that more institutions should be studied to determine the prevalence of suicide clustering in universities and its causes.

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The German Version of the Satisfaction With Life Scale (SWLS)

European Journal of Psychological Assessment ◽

10.1027/1015-5759/a000058 ◽

2011 ◽

Vol 27 (2) ◽

pp. 127-132 ◽

Cited By ~ 180

Author(s):

Heide Glaesmer ◽

Gesine Grande ◽

Elmar Braehler ◽

Marcus Roth

Keyword(s):

Convergent Validity ◽

Satisfaction With Life ◽

Age Groups ◽

Population Based ◽

Factorial Invariance ◽

Satisfaction With Life Scale ◽

Small Samples ◽

Cross Sectional ◽

Confirmatory Factor Analyses ◽

Life Scale

The Satisfaction with Life Scale (SWLS) is the most commonly used measure for life satisfaction. Although there are numerous studies confirming factorial validity, most studies on dimensionality are based on small samples. A controversial debate continues on the factorial invariance across different subgroups. The present study aimed to test psychometric properties, factorial structure, factorial invariance across age and gender, and to deliver population-based norms for the German general population from a large cross-sectional sample of 2519 subjects. Confirmatory factor analyses supported that the scale is one-factorial, even though indications of inhomogeneity of the scale have been detected. Both findings show invariance across the seven age groups and both genders. As indicators of the convergent validity, a positive correlation with social support and negative correlation with depressiveness was shown. Population-based norms are provided to support the application in the context of individual diagnostics.

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Sequential Difficulty Effects During Strategy Execution

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000157 ◽

2012 ◽

Vol 59 (5) ◽

pp. 295-301 ◽

Cited By ~ 35

Author(s):

Kim Uittenhove ◽

Patrick Lemaire

Keyword(s):

Computational Models ◽

Preceding Trial ◽

Human Cognition ◽

Strategy Execution ◽

Strategy Performance ◽

Empirical Implications

In two experiments, we tested the hypothesis that strategy performance on a given trial is influenced by the difficulty of the strategy executed on the immediately preceding trial, an effect that we call strategy sequential difficulty effect. Participants’ task was to provide approximate sums to two-digit addition problems by using cued rounding strategies. Results showed that performance was poorer after a difficult strategy than after an easy strategy. Our results have important theoretical and empirical implications for computational models of strategy choices and for furthering our understanding of strategic variations in arithmetic as well as in human cognition in general.

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Assessing Person Fit With the Information Matrix Test

Methodology ◽

10.1027/1614-2241/a000085 ◽

2015 ◽

Vol 11 (1) ◽

pp. 3-12 ◽

Cited By ~ 2

Author(s):

Jochen Ranger ◽

Jörg-Tobias Kuhn

Keyword(s):

Simulation Study ◽

Type I Error ◽

Information Matrix ◽

Small Samples ◽

Type I ◽

Person Fit ◽

Power Of The Test ◽

Order Expansion ◽

Trait Stability ◽

Information Matrix Test

In this manuscript, a new approach to the analysis of person fit is presented that is based on the information matrix test of White (1982) . This test can be interpreted as a test of trait stability during the measurement situation. The test follows approximately a χ2-distribution. In small samples, the approximation can be improved by a higher-order expansion. The performance of the test is explored in a simulation study. This simulation study suggests that the test adheres to the nominal Type-I error rate well, although it tends to be conservative in very short scales. The power of the test is compared to the power of four alternative tests of person fit. This comparison corroborates that the power of the information matrix test is similar to the power of the alternative tests. Advantages and areas of application of the information matrix test are discussed.

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