In vivo evaluation of porous hydroxyapatite ceramics including bone minerals using pig model

2018 ◽  
Vol 33 (10) ◽  
pp. 689-697 ◽  
Author(s):  
Tomohiro Yokota ◽  
Kazuaki Nakano ◽  
Masaki Nagaya ◽  
Michiyo Honda ◽  
Hiroshi Nagashima ◽  
...  
Keyword(s):  
Pig Model ◽  
In Vivo Evaluation ◽  
Porous Hydroxyapatite ◽  
Hydroxyapatite Ceramics ◽  
Bone Minerals

A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene – In vivo evaluation using a pig model

2013 ◽  
Vol 453 (2) ◽  
pp. 307-314 ◽  
Author(s):  
Waleed Faisal ◽  
Therese Ruane-O’Hora ◽  
Caitriona M. O’Driscoll ◽  
Brendan T. Griffin
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Pig Model ◽  
In Vivo Evaluation

In Vivo Evaluation of Porous Hydroxyapatite/Poly D/L-Lactide Composite for Bone Substitute and Scaffold

2005 ◽  
Vol 284-286 ◽  
pp. 769-774
Author(s):  
Shin Hasegawa ◽  
Jiro Tamura ◽  
Masashi Neo ◽  
Koji Goto ◽  
Yasuo Shikinami ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Bone Remodeling ◽  
Bone Substitute ◽  
Femoral Condyle ◽  
Marrow Cell ◽  
In Vivo Evaluation ◽  
Porous Hydroxyapatite ◽  
Cell Scaffolds

We investigated the biocompatibility, osteoconductivity, and biodegradability of porous composite of Hydroxyapatite (HA) and Poly D/L-lactide (PDLLA). At 6weeks afterimplantation to rabbit femoral condyle, HA/PDLLA was covered with bone and contacted with bone directly. The amounts of newly formed bone in the pores had increased during the examined period. By 26weeks, bone remodeling of formed bone in the pores was seen and bone marrow tissue formation was seen in the pores of HA/PDLLA. Porous HA/PDLLA was resorbed much faster than porous HA as a control. Porous HA/PDLLA was resorbed constantly through the bone formation and bone remodeling but porous HA was hardly resorbed during the period. It might be one of the desirable materials for bone substitute. To evaluate for a scaffold, disc shaped blocks loaded with rat bone marrow cell were implanted in the subcutaneous pouch of the back of syngeneic rat. At 3weeks afterimplantation, newly bone formation in the pores was observed at ectopic site. It also suggested the availability of this material as cell scaffolds.

In Vivo Evaluation of Porous Hydroxyapatite/Collagen Composite as a Carrier of OP-1 in a Rabbit PLF Model

2006 ◽  
Vol 309-311 ◽  
pp. 977-980 ◽  
Author(s):  
Shinichi Sotome ◽  
Hisaya Orii ◽  
Masanori Kikuchi ◽  
Toshiyuki Ikoma ◽  
Akimasa Ishida ◽  
...  
Keyword(s):  
Lumbar Fusion ◽  
High Dose ◽  
Fusion Model ◽  
In Vivo Evaluation ◽  
Porous Hydroxyapatite ◽  
Porous Implant ◽  
Autologous Bone ◽  
Compression Resistance ◽  
Biomechanical Tests

Transplantation surgeries of autologous bone require a second surgery with inherent risks. To avoid these risks, we developed a multi porous implant of hydroxyapatite/collagen composite with desirable biophysical properties (flexibility, elasticity and compression resistance) for use with OP-1 as a graft implant. In this study, we tested the efficacy of this multi porous implant as OP-1 carrier using rabbit posterolateral lumbar fusion model (PLF). PLFs were performed in the following 4 groups of 8 New Zealand white rabbits each: autograft, HAp/Col alone, HAp/Col plus 0.3 mg OP-1, and HAp/Col plus 1.2 mg OP-1. At 5 weeks, fusion masses were analyzed by radiographic and biomechanical tests. Implants consisting of HAp/Col plus OP-1 were more effective than autologous bone in promoting spinal fusion. Low dose and high dose OP-1 were equally effective.

A Porous Hydroxyapatite/Gelatin Nanocomposite Scaffold for Bone Tissue Repair: In Vitro and In Vivo Evaluation

2012 ◽  
Vol 23 (18) ◽  
pp. 2353-2368 ◽  
Author(s):  
Mahmoud Azami ◽  
Shima Tavakol ◽  
Ali Samadikuchaksaraei ◽  
Mehran Solati Hashjin ◽  
Nafiseh Baheiraei ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Repair ◽  
In Vivo Evaluation ◽  
Porous Hydroxyapatite ◽  
Nanocomposite Scaffold

In Vivo Evaluation of Porous Hydroxyapatite/Collagen Composite as a Carrier of OP-1 in a Rabbit PLF Model

2006 ◽  
pp. 977-980
Author(s):  
Shinichi Sotome ◽  
Hisaya Orii ◽  
Masanori Kikuchi ◽  
Toshiyuki Ikoma ◽  
Akimasa Ishida ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Porous Hydroxyapatite

In Vivo Evaluation of Porous Hydroxyapatite/Poly D/L-Lactide Composite for Bone Substitute and Scaffold

2005 ◽  
pp. 769-774
Author(s):  
Shin Hasegawa ◽  
Jiro Tamura ◽  
Masashi Neo ◽  
Koji Goto ◽  
Yasuo Shikinami ◽  
...  
Keyword(s):  
Bone Substitute ◽  
In Vivo Evaluation ◽  
Porous Hydroxyapatite

In Vivo Evaluation of the Release of Zidovudine and Polystyrene Sulfonate from a Dual Intravaginal Bioadhesive Polymeric Device in the Pig Model

2011 ◽  
Vol 100 (4) ◽  
pp. 1416-1435 ◽  
Author(s):  
Valence M.K. Ndesendo ◽  
Viness Pillay ◽  
Yahya E. Choonara ◽  
Lisa C. Du Toit ◽  
Leith C.R. Meyer ◽  
...  
Keyword(s):  
Pig Model ◽  
Polystyrene Sulfonate ◽  
In Vivo Evaluation

Accurate volume measurement for liver surgery in vivo evaluation with a pig model

2004 ◽  
Vol 1268 ◽  
pp. 730-734 ◽  
Author(s):  
Matthias Thorn ◽  
Michael Kremer ◽  
Tobias Heimann ◽  
Bruno M Schmied ◽  
Peter Schemmer ◽  
...  
Keyword(s):  
Liver Surgery ◽  
Volume Measurement ◽  
Pig Model ◽  
In Vivo Evaluation

In vivo evaluation of a porous hydroxyapatite/poly-DL-lactide composite for bone tissue engineering

2007 ◽  
Vol 81A (4) ◽  
pp. 930-938 ◽  
Author(s):  
Shin Hasegawa ◽  
Masashi Neo ◽  
Jiro Tamura ◽  
Shunsuke Fujibayashi ◽  
Mitsuru Takemoto ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
In Vivo Evaluation ◽  
Porous Hydroxyapatite
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