SIMULTANEOUS DETERMINATION OF PRAMOCAINE HCL AND HYDROCORTISONE ACETATE IN PHARMACEUTICAL DOSAGE FORM

2013 ◽  
Vol 36 (19) ◽  
pp. 2774-2784 ◽  
Author(s):  
Hanan A. Merey ◽  
Mohammed A. Mohammed ◽  
Fahima A. Morsy ◽  
Maissa Y. Salem
Author(s):  
Sushil D. Patil ◽  
Pravin B. Shelke ◽  
Priti Aher ◽  
Maswood Ahmed Hafizur Rahman

A simple, rapid, economic, sensitive and precise HPLC method has been developed for the simultaneous determination of Sulphadoxine and Pyrimethamine in pharmaceutical dosage form by taking Tolterodine as an internal standard. The method was carried out using Phenomenex C18 (4.6ID × 250mm; 5µm) column and mobile phase comprised of methanol and Phosphate Buffer in proportion of ratio 60:40 v/v. The flow rate was 1.0mL/min and detection was carried out at 276nm. The retention time of Sulphadoxine, Pyrimethamine and Tolterodine were found to be 2.967, 4.058 and 6.908 respectively. Linearity of Sulphadoxine and Pyrimethamine in the range of 2 to 12μg/mL and 4 to 24μg/mL respectively. The % recoveries of Sulphadoxine and Pyrimethamine were found to be in between 99.93% to 99. 96 % respectively. The proposed method is suitable for the routine quality control analysis for simultaneous determination of Sulphadoxine and Pyrimethamine was in bulk and pharmaceutical dosage form.


2014 ◽  
Vol 4 (2) ◽  
pp. 132-145 ◽  
Author(s):  
Mohamed S. Rizk ◽  
Hanan A. Merey ◽  
Shereen M. Tawakkol ◽  
Mona N. Sweilam

2005 ◽  
Vol 28 (16) ◽  
pp. 2076-2079 ◽  
Author(s):  
Bhaskar Laxmanrao Kolte ◽  
Bharat Baburao Raut ◽  
Adwait Anant Deo ◽  
Manoj Anil Bagool ◽  
Devanand Baburao Shinde

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