Aztreonam Biliary Excretion in Bile Duct Ligated Jaundiced Rats

Tritium-labeled prostaglandin F2 alpha was administered via orogastric tube to bile duct-cannulated suckling and weanling rats to determine if maturational differences were present in the biliary excretion of prostaglandin F2 alpha and metabolites. Animals were killed 2 h after radioactivity administration. Characterization of radioactivity present in bile revealed age-related differences in biliary prostaglandin F2 alpha excretion. Suckling rats had a greater proportion of radioactivity migrating in chromatographic regions of greater polarity than prostaglandin F2 alpha. Compared with the weanling, a significantly greater amount of radioactivity cochromatographed with intact, unmetabolized prostaglandin F2 alpha (33.08 +/- 1.99 vs. 21.38 +/- 1.46). These results indicate that orogastrically administered prostaglandin F2 alpha can be absorbed from the gastrointestinal tract, transported to the liver, and subsequently excreted into bile and detected in an unmetabolized form in suckling and weanling rats. The enterohepatic circulation of milk-derived prostaglandin present in bile may contribute to the overall content of intestinal prostaglandins.

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Biliary excretion of 51chromium in bile-duct cannulated rats

Nutrition Research ◽

10.1016/0271-5317(96)00100-5 ◽

1996 ◽

Vol 16 (6) ◽

pp. 1009-1015 ◽

Cited By ~ 6

Author(s):

Melissa L. Davis-Whitenack ◽

Bernice O. Adeleye ◽

Lester L. Rolf ◽

Barbara J. Stoecker

Keyword(s):

Bile Duct ◽

Biliary Excretion

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Effect of the glycogenolytic gluconeogenetic hormones, glucagon, vasopressin and angiotensin II, on biliary excretion of iodothyronines in rats is possibly related to the inhibition of 5′-monodeiodination in the liver

Journal of Endocrinology ◽

10.1677/joe.0.1210299 ◽

1989 ◽

Vol 121 (2) ◽

pp. 299-302 ◽

Cited By ~ 1

Author(s):

P. Langer ◽

O. Földes ◽

K. Gschwendtová

Keyword(s):

Angiotensin Ii ◽

Bile Duct ◽

Biliary Excretion ◽

Femoral Vein ◽

Control Period ◽

Control Group ◽

Group 2 ◽

Pentobarbital Anaesthesia

ABSTRACT Polyethylene tubes were inserted into the bile duct and femoral vein of rats under pentobarbital anaesthesia and bile was collected for three 2-h periods. After the first (control) period the animals were infused intravenously at a rate of 1·2 ml/h with the following compounds: (1) 0·9% (w/v) NaCl (control group), (2) glucagon (1200 ng/h), (3) vasopressin (1200 ng/h) or (4) angiotensin II (600 ng/h). The concentrations of thyroxine (T4), tri-iodothyronine (T3) and reverse tri-iodothyronine (rT3) in the bile were estimated by radioimmunoassay. No significant differences between groups were found in the biliary excretion of T4 and T3, while the excretion of rT3 after the infusion of all the hormones used was significantly (P < 0·001 at 2 to 4 h of the infusion) increased, no such increase being found in the controls. It may be concluded therefore that the administration of the above hormones resulted in some changes in iodothyronine metabolism in the liver. These may be explained by an inhibition of iodothyronine 5′-monodeiodination related to the glycogenolytic and gluconeogenetic effects of these hormones. Journal of Endocrinology (1989) 121, 299–302

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Biliary excretion of taurolithocholate-sulfate and temocaprilat in cholestatic rats induced by bile duct-ligation and ethinylestradiol

Hepatology Research ◽

10.1016/s1386-6346(02)00028-1 ◽

2002 ◽

Vol 24 (2) ◽

pp. 136-140 ◽

Cited By ~ 2

Author(s):

H Takikawa

Keyword(s):

Bile Duct ◽

Biliary Excretion ◽

Bile Duct Ligation ◽

Duct Ligation

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Effect of sulfobromophthalein on biliary excretion of taurocholate and pravastatin in bile duct-ligated rat

International Hepatology Communications ◽

10.1016/s0928-4346(97)00370-8 ◽

1997 ◽

Vol 6 (6) ◽

pp. 339-344

Author(s):

H TAKIKAWA ◽

N SANO ◽

A SATO ◽

M YAMANAKA

Keyword(s):

Bile Duct ◽

Biliary Excretion

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Stimulation of taurocholic acid synthesis and biliary excretion of lipids

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1961.200.4.855 ◽

1961 ◽

Vol 200 (4) ◽

pp. 855-859 ◽

Cited By ~ 40

Author(s):

Robert E. Kay ◽

Cecil Entenman

Keyword(s):

Bile Duct ◽

Bile Acids ◽

Biliary Excretion ◽

Free Cholesterol ◽

Acid Synthesis ◽

Taurocholic Acid ◽

Perfused Liver ◽

Cholesterol Esters ◽

Bile Fistula ◽

Stimulation Of

The rates of excretion of taurocholic acid and lipids in the bile of the isolated perfused liver and the bile fistula rat were determined. In the bile fistula rats, there was, during the first 12 hours after cannulation, a fall in the excretion of taurocholic acid, which was then followed by an increase in the rate of excretion. The excretion of free cholesterol and phospholipids followed the same excretion pattern as for taurocholic acid, whereas the biliary excretion of glycerides and cholesterol esters was nearly constant. Livers perfused immediately after cannulation of the bile duct excreted only very small amounts of bile acids and lipids in the bile. On the other hand, when livers were perfused 48 hours after cannulation, the bile acids were excreted at a greatly accelerated rate and increased amounts of free cholesterol and phospholipids appeared in the bile. The infusion of cholic acid into a liver, perfused immediately after cannulation of the bile duct, gave rise to an increased biliary excretion of bile acids, free cholesterol and phospholipids.

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Molecular weight as a factor in the excretion of monoquaternary ammonium cations in the bile of the rat, rabbit and guinea pig

Biochemical Journal ◽

10.1042/bj1360967 ◽

1973 ◽

Vol 136 (4) ◽

pp. 967-978 ◽

Cited By ~ 37

Author(s):

Robin D. Hughes ◽

Peter Millburn ◽

R. Tecwyn Williams

Keyword(s):

Molecular Weight ◽

Bile Duct ◽

Biliary Excretion ◽

Guinea Pigs ◽

Species Difference ◽

Faecal Excretion ◽

Molecular Weights ◽

Pyridinium Cations ◽

Monoquaternary Ammonium ◽

Intact Rats

1. The excretion in the bile and urine of intraperitoneally injected14C-labelled monoquaternary ammonium or pyridinium cations was measured in bile-duct-cannulated rats (ten compounds) and in guinea pigs and rabbits (six compounds). 2. Seven of these, namely N-methylpyridinium, tetraethylammonium, trimethylphenylammonium, diethylmethylphenylammonium, methylphenyldipropylammonium, dibenzyldimethylammonium and tribenzylmethylammonium, were excreted largely unchanged in the bile and urine. 3. 3-Hydroxyphenyltrimethylammonium, 3-bromo-N-methylpyridinium and cetyltrimethylammonium were metabolized to an appreciable extent in the rat. 4. In intact rats intraperitoneally injected trimethylphenylammonium (mol.wt. 136) was excreted mainly in the urine, dibenzyldimethylammonium (mol.wt. 226) was excreted in roughly equal amounts in the urine and faeces, and tribenzylmethylammonium (mol.wt. 302) was excreted mainly in the faeces. The faecal excretion of these compounds corresponded to their biliary excretion in bile-duct-cannulated rats. About 3–4% of tribenzyl[14C]methylammonium was eliminated as14CO2. 5. In rats the extent of biliary excretion of four cations with molecular weights in the range 94–164 was less than 10% of the dose, whereas that of five cations with molecular weights 173–302 was greater than 10%. These results and other data from the literature suggested that the molecular weight needed for the biliary excretion of such cations to an extent of 10% or more of the dose was about 200±50. Studies with six cations in guinea pigs and rabbits suggest that this value applies also to these species. 6. The results suggest that the threshold molecular weight for the appreciable (>10%) biliary excretion of monoquaternary cations is different from that for anions (Millburn et al., 1967a; Hirom et al., 1972b). With rats, guinea pigs and rabbits, no significant species difference was noted, whereas with anions there is a marked species difference.

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