scholarly journals Simultaneous Epstein Barr Virus and Cytomegalovirus Infection Accompanied by Leiomyomatous Change in a Well-Differentiated Liposarcoma in a Patient With Long-Term Corticosteroid Treatment

Sarcoma ◽  
1997 ◽  
Vol 1 (1) ◽  
pp. 55-58
Author(s):  
Paul R. A. Sars ◽  
Willemina M. Molenaar ◽  
Jan Koudstaal ◽  
Harald J. Hoekstra
Gene Reports ◽  
2021 ◽  
pp. 101208
Author(s):  
Farhad Torfi ◽  
Freshteh Kamani ◽  
Shaian Tavakolian ◽  
Mohammad Reza Hosseini ◽  
Najmeh Sadat Boland Nazar ◽  
...  

2018 ◽  
Vol 185 (2) ◽  
pp. 377-380 ◽  
Author(s):  
Amie E. Hwang ◽  
Vickie Marshall ◽  
David V. Conti ◽  
Bharat N. Nathwani ◽  
Thomas M. Mack ◽  
...  

2019 ◽  
pp. practneurol-2019-002356 ◽  
Author(s):  
Andrew Lee ◽  
Leslie R Bridges ◽  
Mark Lloyd ◽  
Robert Barker ◽  
Damian R Wren ◽  
...  

The incidence of Epstein–Barr virus (EBV)associated lymphoproliferative disorders has increased with greater use of immunomodulatory therapies. We present a woman who developed subacute cognitive decline and unilateral weakness while taking long-term mycophenolate mofetil for granulomatosis with polyangiitis; her postmortem brain histopathology confirmed an EBV-driven lymphoproliferative disorder. Clinicians must have a high index of suspicion for EBV-driven lymphoma in people taking long-term immunosuppression who develop new neurological problems. We review the role of mycophenolate mofetil in EBV-driven lymphoproliferative disorders, and discuss checking EBV status in all patients starting immunosuppression and in older people already taking immunosuppression.


Blood ◽  
2001 ◽  
Vol 97 (4) ◽  
pp. 1131-1133 ◽  
Author(s):  
Maurizio Arico ◽  
Shinsaku Imashuku ◽  
Rita Clementi ◽  
Shigeyoshi Hibi ◽  
Tomoko Teramura ◽  
...  

Abstract The hemophagocytic lymphohistiocytoses (HLH) comprise a heterogeneous group of disorders characterized by dysregulated activation of T cells and macrophages. Although some patients with HLH harbor perforin gene mutations, the cause of the remaining cases is not known. The phenotype of HLH bears a strong resemblance to X-linked lymphoproliferative disease (XLP), an Epstein-Barr virus (EBV)-associated immunodeficiency resulting from defects in SH2D1A, a small SH2 domain-containing protein expressed in T lymphocytes and natural killer cells. Here it is shown that 4 of 25 male patients with HLH who were examined harbored germline SH2D1A mutations. Among these 4 patients, only 2 had family histories consistent with XLP. On the basis of these findings, it is suggested that all male patients with EBV-associated hemophagocytosis be screened for mutations in SH2D1A. Patients identified as having XLP should undergo genetic counseling, and be followed long-term for development of lymphoma and hypogammaglobulinemia.


2000 ◽  
pp. 827-833 ◽  
Author(s):  
Gianpietro Dotti ◽  
Roberto Fiocchi ◽  
Teresio Motta ◽  
Amando Gamba ◽  
Eliana Gotti ◽  
...  

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