Consolidation deficits in traumatic brain injury: The core and residual verbal memory defect

2013 ◽  
Vol 36 (1) ◽  
pp. 58-73 ◽  
Author(s):  
Rodney D. Vanderploeg ◽  
Alison J. Donnell ◽  
Heather G. Belanger ◽  
Glenn Curtiss
2003 ◽  
Vol 4 (2) ◽  
pp. 155-167 ◽  
Author(s):  
Karleigh Jayne Kwapil ◽  
Gina Geffen ◽  
Ken McFarland ◽  
Veronica Eileen DeMonte

AbstractThe present study aimed to determine whether including a sensitive test of immediate and delayed recall would improve the diagnostic validity of the Rapid Screen of Concussion (RSC) in mild Traumatic Brain Injury (mTBI) versus orthopaedic clinical samples. Two studies were undertaken. In Study 1, the performance of 156 mTBI and 145 orthopaedic participants was analysed to identify the number of individuals who performed at ceiling on the verbal memory subtest of the RSC, as this test required immediate and delayed recall of only five words. A second aim was to determine the sensitivity and specificity levels of the RSC. Study 2 aimed to examine whether replacement of the verbal memory subtest with the 12-word Hopkins Verbal Learning Test (HVLT) could improve the sensitivity of the RSC in a new sample of 26 mTBI and 30 orthopaedic participants. Both studies showed that orthopaedic participants outperformed mTBI participants on each of the selected measures. Study 1 showed that 14% of mTBI participants performed at ceiling on the immediate and 21.2% on delayed recall test. Performance on the original battery yielded a sensitivity of 82%, specificity of 80% and overall correct classification of 81.5% participants. In Study 2, inclusion of the HVLT improved sensitivity to a level of 88.5%, decreased specificity to a level of 70% and resulted in an overall classification rate of 80%. It was concluded that although inclusion of the five-word subtest in the RSC can successfully distinguish concussed from non-concussed individuals, use of the HVLT in this protocol yields a more sensitive measure of subtle cognitive deficits following mTBI.


2021 ◽  
Vol 36 (6) ◽  
pp. 1139-1139
Author(s):  
Kristina E Smith ◽  
Daniel W Lopez-Hernandez ◽  
Alexis Bueno ◽  
Rachel A Rugh-Fraser ◽  
Bethany A Nordberg ◽  
...  

Abstract Objective We examined perceived workload as it is related to Brief Visual Memory Test-Revised (BVMT-R) short-delay and long-delay performance in traumatic brain injury (TBI) and healthy comparison (HC) participants. Method The sample consisted of 39 TBI participants and 54 HC participants. Demographically corrected BVMT-R scores were used to evaluate short-delay and long-delay performances. The perceived workload was measured using the NASA-TLX. Results ANOVA revealed that the HC group outperformed the TBI group on the BVMT-R short-delay and long-delay score, p < 05, η p 2 = 0.05. ANCOVAs controlling for age were used to evaluate NASA-TLX group differences. In regards to the NASA-TLX, TBI participants reported higher levels of physical demand, effort, frustration and overall subjective workload on the BVMT-R short-delay compared to HC participants, p < 05, η p 2 = 0.01–0.09. Furthermore, on the long-delay of the BVMT-R, the NASA-TLX revealed that the TBI group reported higher levels of temporal demand, effort, frustration and overall subjective workload compared to the HC group, p < 0.05, η p 2 = 0.05–0.14. Conclusions Results revealed that TBI participants demonstrated worse BVMT-R performances than HC participants. However, TBI survivors reported higher perceived workload demands compared to the HC group in both short-delay and long-delay of the BVMT-R. Our findings suggest that TBI impacts non-verbal memory performance in both BVMT-R short-delay and long-delay. Also, brain injury may be impacting TBI survivors’ awareness of their non-verbal memory performance. Further work is required to determine what drives the impaired perception of non-verbal memory performance among TBI survivors.


1998 ◽  
Vol 20 (2) ◽  
pp. 245-258 ◽  
Author(s):  
Mary J. Roman ◽  
Dean C. Delis ◽  
Lee Willerman ◽  
Mark Magulac ◽  
Theresa L. Demadura ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Hui Liu ◽  
Gou ping Qiu ◽  
Fei Zhuo ◽  
Wei hua Yu ◽  
Shan quan Sun ◽  
...  

Objective. To understand how aquaporin4 (AQP4) and dystroglycan (DG) polarized distribution change and their roles in brain edema formation after traumatic brain injury (TBI).Methods. Brain water content, Evans blue detection, real-time PCR, western blot, and immunofluorescence were used.Results. At an early stage of TBI, AQP4 and DG maintained vessel-like pattern in perivascular endfeet; M1, M23, and M1/M23 were increased in the core lesion. At a later stage of TBI, DG expression was lost in perivascular area, accompanied with similar but delayed change of AQP4 expression; expression of M1, M23, and DG and the ratio of M1/M2 were increased.Conclusion. At an early stage, AQP4 and DG maintained the polarized distribution. Upregulated M1 and M23 could retard the cytotoxic edema formation. At a later stage AQP4 and DG polarized expression were lost from perivascular endfeet and induced the worst cytotoxic brain edema. The alteration of DG expression could regulate that of AQP4 expression after TBI.


Neurology ◽  
2008 ◽  
Vol 71 (15) ◽  
pp. 1199-1201 ◽  
Author(s):  
C. L. MacDonald ◽  
N. Schwarze ◽  
S. N. Vaishnavi ◽  
A. A. Epstein ◽  
A. Z. Snyder ◽  
...  

2015 ◽  
Vol 22 (5) ◽  
pp. 600-617 ◽  
Author(s):  
Tamar Silberg ◽  
Jaana Ahonniska-Assa ◽  
Miriam Levav ◽  
Roni Eliyahu ◽  
Tamar Peleg-Pilowsky ◽  
...  

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