Plasma N-terminal Proatrial Natriuretic Factor can Predict Normal Pulmonary Capillary Wedge Pressure in Cardiac Transplant Recipients

2001 ◽  
Vol 35 (6) ◽  
pp. 367-371
Author(s):  
M. G. Dahle ◽  
L. Gullestad ◽  
S. Simonsen
1998 ◽  
Vol 135 (4) ◽  
pp. 641-646 ◽  
Author(s):  
David R. Richards ◽  
Yvonne Gilliland ◽  
J.Alberto Bernal ◽  
Frank W. Smart ◽  
Dwight D. Stapleton ◽  
...  

1988 ◽  
Vol 118 (2) ◽  
pp. 168-172 ◽  
Author(s):  
Niels Keller ◽  
John Larsen ◽  
Roman Sykulski ◽  
Tommy Storm ◽  
Gorm Thamsborg

Abstract. In order to evaluate the potential relationship between atrial pressure development and release of atrial natriuretic factor (ANF), 33 patients with congestive heart failure were investigated with rightsided heart catheterization during supine graded bicycle exercise. Resting plasma ANF levels were higher in patients with heart failure as compared with normal controls, 75.1 ± 45.6 pmol/l vs 12.3 ± 6.2 pmol/l (mean ± sd, N = 33 and N = 42, respectively) and correlated with right atrial, pulmonary arterial and pulmonary capillary wedge pressures. During exercise, central pressures rose steeply with a simultaneous increase in plasma ANF in all patients. Plasma ANF levels correlated with heart rate at a workload of 25 w, to pulmonary arterial and pulmonary capillary wedge pressure at 50 w, and to pulmonary capillary wedge pressure at 75 w. The increments in ANF levels between the different workloads during exercise did not correlate with the corresponding increments in pressure values. In congestive heart failure, the capability of ANF secretion in consequence to pressure stimuli is preserved, and left atrial pressure seems to be the major stimulus for ANF release during exercise.


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