scholarly journals Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents

2021 ◽  
Vol 36 (1) ◽  
pp. 940-953
Author(s):  
Alessandro Deplano ◽  
Jessica Karlsson ◽  
Federica Moraca ◽  
Mona Svensson ◽  
Claudia Cristiano ◽  
...  
Keyword(s):  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Analgesic Agents ◽  
Amide Hydrolase ◽  
Inhibitory Potential ◽  
Fatty Acid Amide

Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors

2014 ◽  
Vol 22 (4) ◽  
pp. 1468-1478 ◽  
Author(s):  
Mitsunori Kono ◽  
Takahiro Matsumoto ◽  
Toshihiro Imaeda ◽  
Toru Kawamura ◽  
Shinji Fujimoto ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Amide Hydrolase ◽  
Synthesis And Biological Evaluation ◽  
Fatty Acid Amide

scholarly journals Design, Synthesis, and In Vitro Evaluation of Carbamate Derivatives of 2-Benzoxazolyl- and 2-Benzothiazolyl-(3-hydroxyphenyl)-methanones as Novel Fatty Acid Amide Hydrolase Inhibitors

2007 ◽  
Vol 50 (17) ◽  
pp. 4236-4242 ◽  
Author(s):  
Mikko J. Myllymäki ◽  
Susanna M. Saario ◽  
Antti O. Kataja ◽  
Joel A. Castillo-Melendez ◽  
Tapio Nevalainen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Design Synthesis ◽  
In Vitro Evaluation ◽  
Amide Hydrolase ◽  
Derivatives Of ◽  
Fatty Acid Amide

scholarly journals Design, Synthesis, and In Vitro Evaluation of Carbamate Derivatives of 2-Benzoxazolyl- and 2-Benzothiazolyl-(3-hydroxyphenyl)-methanones as Novel Fatty Acid Amide Hydrolase Inhibitors.

2007 ◽  
Vol 50 (23) ◽  
pp. 5868-5868
Author(s):  
Mikko J. Myllymäki ◽  
Susanna M. Saario ◽  
Antti O. Kataja ◽  
Joel A. Castillo-Melendez ◽  
Tapio Nevalainen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Design Synthesis ◽  
In Vitro Evaluation ◽  
Amide Hydrolase ◽  
Derivatives Of ◽  
Fatty Acid Amide

scholarly journals Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis

2021 ◽  
Author(s):  
Sarah Rieck ◽  
Sofia Kilgus ◽  
Johanna H. Meyer ◽  
Hao Huang ◽  
Lan Zhao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Endothelial Cells ◽  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Antiangiogenic Effect ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

Objective: Pathological angiogenesis is a hallmark of various diseases characterized by local hypoxia and inflammation. These disorders can be treated with inhibitors of angiogenesis, but current compounds display a variety of side effects and lose efficacy over time. This makes the identification of novel signaling pathways and pharmacological targets involved in angiogenesis a top priority. Approach and Results: Here, we show that inactivation of FAAH (fatty acid amide hydrolase), the enzyme responsible for degradation of the endocannabinoid anandamide, strongly impairs angiogenesis in vitro and in vivo. Both, the pharmacological FAAH inhibitor URB597 and anandamide induce downregulation of gene sets for cell cycle progression and DNA replication in endothelial cells. This is underscored by cell biological experiments, in which both compounds inhibit proliferation and migration and evoke cell cycle exit of endothelial cells. This prominent antiangiogenic effect is also of pathophysiological relevance in vivo, as laser-induced choroidal neovascularization in the eye of FAAH −/− mice is strongly reduced. Conclusions: Thus, elevation of endogenous anandamide levels by FAAH inhibition represents a novel antiangiogenic mechanism.

scholarly journals A Second Generation of Carbamate-Based Fatty Acid Amide Hydrolase Inhibitors with Improved Activity in vivo

ChemMedChem ◽  
2009 ◽  
Vol 4 (9) ◽  
pp. 1505-1513 ◽  
Author(s):  
Jason R. Clapper ◽  
Federica Vacondio ◽  
Alvin R. King ◽  
Andrea Duranti ◽  
Andrea Tontini ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Second Generation ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Amide Hydrolase ◽  
Fatty Acid Amide
Sign in / Sign up

Export Citation Format

Share Document