Synthesis, In Vitro and In Vivo Evaluation, and Radiolabeling of Aryl Anandamide Analogues as Candidate Radioligands for In Vivo Imaging of Fatty Acid Amide Hydrolase in the Brain

2009 ◽  
Vol 52 (15) ◽  
pp. 4613-4622 ◽  
Author(s):  
Leonie wyffels ◽  
Giulio G. Muccioli ◽  
Sylvie De Bruyne ◽  
Lieselotte Moerman ◽  
Johan Sambre ◽  
...  
Keyword(s):  
Fatty Acid ◽  
In Vivo Imaging ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
In Vivo Evaluation ◽  
Amide Hydrolase ◽  
The Brain ◽  
Fatty Acid Amide

In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor

2017 ◽  
Vol 815 ◽  
pp. 42-48 ◽  
Author(s):  
Tomonari Watabiki ◽  
Noriko Tsuji ◽  
Tetsuo Kiso ◽  
Tohru Ozawa ◽  
Fumie Narazaki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Pharmacological Characterization ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

scholarly journals Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase

2013 ◽  
Vol 21 (14) ◽  
pp. 4351-4357 ◽  
Author(s):  
Oleg Sadovski ◽  
Justin W. Hicks ◽  
Jun Parkes ◽  
Roger Raymond ◽  
José Nobrega ◽  
...  
Keyword(s):  
Fatty Acid ◽  
In Vivo Imaging ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

scholarly journals The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)

2012 ◽  
Vol 39 (7) ◽  
pp. 1058-1067 ◽  
Author(s):  
Marc B. Skaddan ◽  
Lei Zhang ◽  
Douglas S. Johnson ◽  
Aijun Zhu ◽  
Kenneth R. Zasadny ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
In Vivo Evaluation ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

Design and synthesis of new carbamates as inhibitors for fatty acid amide hydrolase and cholinesterases: Molecular dynamic, in vitro and in vivo studies

2021 ◽  
Vol 109 ◽  
pp. 104684
Author(s):  
Mahdi Faal Maleki ◽  
Hamid Nadri ◽  
Mostafa Kianfar ◽  
Najmeh Edraki ◽  
Farhad Eisvand ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Molecular Dynamic ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
In Vivo Studies ◽  
Design And Synthesis ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

scholarly journals Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis

2021 ◽  
Author(s):  
Sarah Rieck ◽  
Sofia Kilgus ◽  
Johanna H. Meyer ◽  
Hao Huang ◽  
Lan Zhao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Endothelial Cells ◽  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Antiangiogenic Effect ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

Objective: Pathological angiogenesis is a hallmark of various diseases characterized by local hypoxia and inflammation. These disorders can be treated with inhibitors of angiogenesis, but current compounds display a variety of side effects and lose efficacy over time. This makes the identification of novel signaling pathways and pharmacological targets involved in angiogenesis a top priority. Approach and Results: Here, we show that inactivation of FAAH (fatty acid amide hydrolase), the enzyme responsible for degradation of the endocannabinoid anandamide, strongly impairs angiogenesis in vitro and in vivo. Both, the pharmacological FAAH inhibitor URB597 and anandamide induce downregulation of gene sets for cell cycle progression and DNA replication in endothelial cells. This is underscored by cell biological experiments, in which both compounds inhibit proliferation and migration and evoke cell cycle exit of endothelial cells. This prominent antiangiogenic effect is also of pathophysiological relevance in vivo, as laser-induced choroidal neovascularization in the eye of FAAH −/− mice is strongly reduced. Conclusions: Thus, elevation of endogenous anandamide levels by FAAH inhibition represents a novel antiangiogenic mechanism.

scholarly journals A Second Generation of Carbamate-Based Fatty Acid Amide Hydrolase Inhibitors with Improved Activity in vivo

ChemMedChem ◽  
2009 ◽  
Vol 4 (9) ◽  
pp. 1505-1513 ◽  
Author(s):  
Jason R. Clapper ◽  
Federica Vacondio ◽  
Alvin R. King ◽  
Andrea Duranti ◽  
Andrea Tontini ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Second Generation ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

328 Inhibition of the fatty acid amide hydrolase (FAAH) reduces in vivo spontaneous seminal vesicle contractions and increases latency to apomorphine-induced ejaculation

2013 ◽  
Vol 12 (1) ◽  
pp. e328
Author(s):  
G. La Croce ◽  
A. Bettiga ◽  
R. Buono ◽  
G. Colciago ◽  
F. Benigni ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Seminal Vesicle ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

ω-Imidazolyl- and ω-Tetrazolylalkylcarbamates as Inhibitors of Fatty Acid Amide Hydrolase: Biological Activity and in vitro Metabolic Stability

ChemMedChem ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. 429-443 ◽  
Author(s):  
Tobias Terwege ◽  
Walburga Hanekamp ◽  
David Garzinsky ◽  
Simone König ◽  
Oliver Koch ◽  
...  
Keyword(s):  
Biological Activity ◽  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Metabolic Stability ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

scholarly journals Fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduces viability, migration and invasiveness of human colon adenocarcinoma Colo-205 cell line: an in vitro study

2017 ◽  
Vol 64 (3) ◽  
pp. 519-525 ◽  
Author(s):  
Andrzej Wasilewski ◽  
Urszula Krajewska ◽  
Katarzyna Owczarek ◽  
Urszula Lewandowska ◽  
Jakub Fichna
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Colon Adenocarcinoma ◽  
In Vitro Study ◽  
Human Colon ◽  
Amide Hydrolase ◽  
Human Colon Adenocarcinoma ◽  
Fatty Acid Amide
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