The relationship between practice setting and management of preterm premature rupture of membranes

Background: Preterm premature rupture of membranes (PPROM) increases the risk of prematurity and leads to a number of other perinatal and neonatal complications. Prolonged latency interval increases probability of complications in mothers with PPROM. The aim of this study was to assess the relationship between the myometrial thickness and the length of latency interval after PPROM.Methods: This study included 62 pregnant women admitted due to spontaneous PPROM from 26 to 37 weeks gestational age. All selected cases were subjected to full medical history, full clinical examination, laboratory investigations, and ultrasound evaluation with measurement of myometrium thickness at lower uterine segment and uterine fundus, measurement of amniotic fluid index.Results: A total 32 (51.7%) of our patients had latency interval <1 week while the rest of patients had latency interval ≥1 week with mean latency interval value was 5.45±2.4 days. Sonographic evaluation of the myometrial thickness showed that the mean thickness at lower uterine segment was 6.6±1.26 mm and at fundus was 6.1±1.28 mm. we found that at cut off point ≥6.9 mm lower uterine segment myometrial thickness had 87.5% sensitivity and 93.3% specificity in prediction of latency interval≥1 week, while at cut off point≥6.4 mm uterine fundus myometrial thickness had 81.3% sensitivity and 63.3% specificity in prediction of latency interval more than 1 week.Conclusions: Sonographic evaluation of myometrial thickness appears to be helpful in prediction of latency interval in PPROM.

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The relationship between the latency period, infection markers, and oxidant and antioxidant states in women with preterm premature rupture of membranes

Irish Journal of Medical Science (1971 -) ◽

10.1007/s11845-017-1570-7 ◽

2017 ◽

Vol 186 (4) ◽

pp. 965-970

Author(s):

N. Ilhan ◽

B. K. Aygun ◽

H. Gungor

Keyword(s):

Latency Period ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

The Relationship ◽

Infection Markers

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The Relationship between Premature Rupture of Membranes and Maternal and Neonatal Outcomes

Tanta Scientific Nursing Journal ◽

10.21608/tsnj.2018.69004 ◽

2018 ◽

Vol 15 (3) ◽

pp. 58-78

Author(s):

Sara Anwar

Keyword(s):

Neonatal Outcomes ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Maternal And Neonatal Outcomes ◽

The Relationship

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Preterm Premature Rupture of Membranes in Twins: Comparison of Rupture in the Presenting Versus Non-presenting Sac

Journal of Obstetrics and Gynaecology Canada ◽

10.1016/j.jogc.2019.06.016 ◽

2020 ◽

Vol 42 (2) ◽

pp. 163-168 ◽

Cited By ~ 1

Author(s):

Elad Mei-Dan ◽

Zoe Hutchison ◽

Mark Osmond ◽

Susan Pakenham ◽

Eugene Ng ◽

...

Keyword(s):

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture

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Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/025, February 2019) – Part 2 with Recommendations on the Tertiary Prevention of Preterm Birth and the Management of Preterm Premature Rupture of Membranes

Geburtshilfe und Frauenheilkunde ◽

10.1055/a-0903-2735 ◽

2019 ◽

Vol 79 (08) ◽

pp. 813-833 ◽

Cited By ~ 2

Author(s):

Richard Berger ◽

Harald Abele ◽

Franz Bahlmann ◽

Ivonne Bedei ◽

Klaus Doubek ◽

...

Keyword(s):

Preterm Birth ◽

German Society ◽

Consensus Conference ◽

Tertiary Prevention ◽

Short Version ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Gynecology And Obstetrics ◽

Self Help Groups

Abstract Aims This is an official guideline of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (ÖGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The aim of this guideline is to improve the prediction, prevention and management of preterm birth based on evidence obtained from recently published scientific literature, the experience of the members of the guideline commission and the views of self-help groups. Methods The members of the participating medical societies and organizations developed Recommendations and Statements based on the international literature. The Recommendations and Statements were adopted following a formal consensus process (structured consensus conference with neutral moderation, voting done in writing using the Delphi method to achieve consensus). Recommendations Part 2 of this short version of the guideline presents Statements and Recommendations on the tertiary prevention of preterm birth and the management of preterm premature rupture of membranes.

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Neonatal lymphocyte subpopulations analysis and maternal preterm premature rupture of membranes: a pilot study

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2021-0375 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Margherita Amadi ◽

Silvia Visentin ◽

Francesca Tosato ◽

Paola Fogar ◽

Giulia Giacomini ◽

...

Keyword(s):

T Cells ◽

Immune System ◽

T Cell ◽

T Helper Cells ◽

Lymphocyte Subpopulations ◽

T Helper ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Helper Cells

Abstract Objectives Preterm premature rupture of membranes (pPROM) causes preterm delivery, and increases maternal T-cell response against the fetus. Fetal inflammatory response prompts maturation of the newborn’s immunocompetent cells, and could be associated with unfavorable neonatal outcome. The aims were to examine the effects of pPROM (Mercer BM. Preterm premature rupture of the membranes: current approaches to evaluation and management. Obstet Gynecol Clin N Am 2005;32:411) on the newborn’s and mother’s immune system and (Test G, Levy A, Wiznitzer A, Mazor M, Holcberg G, Zlotnik A, et al. Factors affecting the latency period in patients with preterm premature rupture of membranes (pPROM). Arch Gynecol Obstet 2011;283:707–10) to assess the predictive value of immune system changes in neonatal morbidity. Methods Mother-newborn pairs (18 mothers and 23 newborns) who experienced pPROM and controls (11 mothers and 14 newborns), were enrolled. Maternal and neonatal whole blood samples underwent flow cytometry to measure lymphocyte subpopulations. Results pPROM-newborns had fewer naïve CD4 T-cells, and more memory CD4 T-cells than control newborns. The effect was the same for increasing pPROM latency times before delivery. Gestational age and birth weight influenced maturation of the newborns’ lymphocyte subpopulations and white blood cells, notably cytotoxic T-cells, regulatory T-cells, T-helper cells (absolute count), and CD4/CD8 ratio. Among morbidities, fewer naïve CD8 T-cells were found in bronchopulmonary dysplasia (BPD) (p=0.0009), and more T-helper cells in early onset sepsis (p=0.04). Conclusions pPROM prompts maturation of the newborn’s T-cell immune system secondary to antigenic stimulation, which correlates with pPROM latency. Maternal immunity to inflammatory conditions is associated with a decrease in non-major histocompatibility complex (MHC)-restricted cytotoxic cells.

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