QUAD versus cfDNA in an urban population in the second trimester for detection of trisomy 21: a cost sensitivity analysis

2016 ◽  
Vol 30 (19) ◽  
pp. 2334-2339
Author(s):  
Sarah Crimmins ◽  
Lauren Doyle ◽  
Julia Slejko ◽  
Jerome N. Kopelman ◽  
Ozhan Turan
Keyword(s):  
Sensitivity Analysis ◽  
Trisomy 21 ◽  
Urban Population ◽  
Second Trimester ◽  
Cost Sensitivity

Correlation of ultrasound findings and biochemical markers in the second trimester of pregnancy in fetuses with trisomy 21

2002 ◽  
Vol 22 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Vivienne L. Souter ◽  
David A. Nyberg ◽  
Amira El-Bastawissi ◽  
Arthur Zebelman ◽  
Fred Luthhardt ◽  
...  
Keyword(s):  
Biochemical Markers ◽  
Trisomy 21 ◽  
Second Trimester ◽  
Ultrasound Findings

The Natural History of Trisomy 21: Outcome Data from a Large Tertiary Referral Centre

2021 ◽  
pp. 1-7
Author(s):  
Clare O’Connor ◽  
Rebecca Moore ◽  
Peter McParland ◽  
Heather Hughes ◽  
Barbara Cathcart ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
Pregnancy Loss ◽  
Loss Rate ◽  
Outcome Data ◽  
Second Trimester ◽  
Referral Centre ◽  
Tertiary Referral ◽  
Tertiary Referral Centre ◽  
History Of ◽  
Baseline Demographic

<b><i>Objective:</i></b> The aim of the study was to prospectively gather data on pregnancy outcomes of prenatally diagnosed trisomy 21 (T21) in a large tertiary referral centre. <b><i>Methods:</i></b> Data were gathered prospectively in a large tertiary referral centre over 5 years from 2013 to 2017 inclusively. Baseline demographic and pregnancy outcome data were recorded on an anonymized computerized database. <b><i>Results:</i></b> There were 1,836 congenital anomalies diagnosed in the study period including 8.9% (<i>n</i> = 165) cases of T21. 79% (<i>n</i> = 131) were age 35 or older at diagnosis. 79/113 (69.9%) women chose a termination of pregnancy (TOP) following a diagnosis of T21. Amongst pregnancies that continued, there were 4 second-trimester miscarriages (4/34, 11.7%), 9 stillbirths (9/34, 26.4%), and 1 neonatal death, giving an overall pregnancy and neonatal loss rate of 14/34 (41.1%). <b><i>Conclusion:</i></b> The risk of foetal loss in prenatally diagnosed T21 is high at 38% with an overall pregnancy loss rate of 41.1%. This information may be of benefit when counselling couples who are faced with a diagnosis of T21 particularly in the context of limited access to TOP.

Indication-specific accuracy of second-trimester genetic ultrasonography for the detection of trisomy 21

1999 ◽  
Vol 181 (5) ◽  
pp. 1045-1048 ◽  
Author(s):  
Anthony M. Vintzileos ◽  
Edwin R. Guzman ◽  
John C. Smulian ◽  
Debra L. Day-Salvatore ◽  
Robert A. Knuppel
Keyword(s):  
Trisomy 21 ◽  
Second Trimester
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