The protective effects of sesamol in a neonatal rat model of necrotizing enterocolitis

2018 ◽  
Vol 33 (6) ◽  
pp. 889-894 ◽  
Author(s):  
Emine Burcu Cigsar ◽  
Cetin Ali Karadag ◽  
Canan Tanik ◽  
Abdurrahman Fatih Aydin ◽  
Ali Ihsan Dokucu
Keyword(s):  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Neonatal Rat ◽  
Protective Effects ◽  
Neonatal Rat Model

scholarly journals Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis

2012 ◽  
Vol 47 (9) ◽  
pp. 1652-1657 ◽  
Author(s):  
Ramazan Ozdemir ◽  
Sadık Yurttutan ◽  
Fatma Nur Sarı ◽  
Bulent Uysal ◽  
Hatice Germen Unverdi ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Neonatal Rat ◽  
Antioxidant Effects ◽  
Neonatal Rat Model

Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model

2002 ◽  
Vol 282 (1) ◽  
pp. G156-G164 ◽  
Author(s):  
Bohuslav Dvorak ◽  
Melissa D. Halpern ◽  
Hana Holubec ◽  
Catherine S. Williams ◽  
Debra L. McWilliam ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Mrna Expression ◽  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
Gastrointestinal Disease ◽  
Neonatal Rat ◽  
Epidermal Growth ◽  
Neonatal Rat Model

Necrotizing enterocolitis (NEC) is the most common gastrointestinal disease of prematurely born infants. Maternal milk plays an important protective role against NEC development and is the major source of epidermal growth factor (EGF) for neonates. The aim of this study was to examine the effect of orally administered EGF on the incidence of NEC in a neonatal rat model. Newborn rats were artificially fed either with growth factor-free rat milk substitute (RMS) or RMS supplemented with 500 ng/ml of EGF (RMS+EGF). Experimental NEC was induced by exposure to asphyxia and cold stress. Development of NEC was evaluated by gross and histological scoring of damage in the ileum. Ileal EGF receptor (EGF-R), EGF, and transforming growth factor-α mRNA expression was assessed by RT competitive-PCR, and the EGF-R was localized by immunohistochemistry. EGF supplementation of formula reduced the incidence and severity of NEC in rats (13/16 RMS vs. 4/13 RMS+EGF). Ileal EGF-R mRNA expression was markedly increased in the RMS group compared with RMS+EGF. Enhanced EGF-R expression in the RMS group was localized predominantly in the epithelial cells of injured ileum. These data suggest a new potential therapeutic approach for the prevention and treatment of NEC.

scholarly journals Pentoxifylline Reduces the Incidence and Severity of Necrotizing Enterocolitis in a Neonatal Rat Model

2006 ◽  
Vol 60 (2) ◽  
pp. 185-189 ◽  
Author(s):  
Javeed Travadi ◽  
Sanjay Patole ◽  
Adrian Charles ◽  
Bohuslav Dvorak ◽  
Dorota Doherty ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Neonatal Rat ◽  
Neonatal Rat Model

Hyperbaric oxygen therapy reduces the severity of necrotizing enterocolitis in a neonatal rat model

2009 ◽  
Vol 44 (3) ◽  
pp. 534-540 ◽  
Author(s):  
Ahmet Guven ◽  
Gokhan Gundogdu ◽  
Bulent Uysal ◽  
Hakan Cermik ◽  
Mustafa Kul ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Hyperbaric Oxygen ◽  
Rat Model ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Neonatal Rat ◽  
Neonatal Rat Model

Protective Effects of Platelet-Activating Factor Antagonist ABT-491 on the Peripheral Nerves in Hypoxic Ischemia-Induced Neonatal Rat Model

2011 ◽  
Vol 31 (5) ◽  
pp. 1179-1185
Author(s):  
Belgin BÜYÜKAKILLI ◽  
Aytuğ ATICI ◽  
Zekeriya BÜYÜKDERELİ ◽  
Bahar TAŞDELEN ◽  
Sevgi GÜNEŞ ◽  
...  
Keyword(s):  
Rat Model ◽  
Peripheral Nerves ◽  
Platelet Activating Factor ◽  
Neonatal Rat ◽  
Protective Effects ◽  
Hypoxic Ischemia ◽  
Factor Antagonist ◽  
Neonatal Rat Model

Deficiency of intestinal alkaline phosphatase in newborns predisposes to necrotizing enterocolitis in a neonatal rat model

2011 ◽  
Vol 213 (3) ◽  
pp. S85
Author(s):  
Rebecca M. Rentea ◽  
Jill S. Whitehouse ◽  
Jennifer L. Liedel ◽  
Kirkwood A. Pritchard ◽  
Alan N. Mayer ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Neonatal Rat ◽  
Intestinal Alkaline Phosphatase ◽  
Neonatal Rat Model
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