Effects of lobetyolin on xanthine oxidase activity in vitro and in vivo: weak and mixed inhibition

2019 ◽  
pp. 1-4 ◽  
Author(s):  
In-Soo Yoon ◽  
Seung-Sik Cho
Keyword(s):  
Xanthine Oxidase ◽  
Oxidase Activity ◽  
Mixed Inhibition ◽  
Xanthine Oxidase Activity

Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo

2016 ◽  
Vol 7 (10) ◽  
pp. 4239-4246 ◽  
Author(s):  
Jhih-Jia Jhang ◽  
Jia-Wei Ong ◽  
Chi-Cheng Lu ◽  
Chin-Lin Hsu ◽  
Jia-Hong Lin ◽  
...  
Keyword(s):  
Uric Acid ◽  
Xanthine Oxidase ◽  
Serum Uric Acid ◽  
Oxidase Activity ◽  
Xanthine Oxidase Activity

Uric acid is a metabolite obtained from purine by xanthine oxidase activity (XO) and high levels of serum uric acid leads to hyperuricemia and gout.

8-Azaguanine, 3, 3' -4, 4' -tetrahydroxy-chalcone and purine in experimental shock in the rat

1960 ◽  
Vol 198 (3) ◽  
pp. 501-506
Author(s):  
Aaron Janoff ◽  
B. W. Zweifach
Keyword(s):  
Uric Acid ◽  
Xanthine Oxidase ◽  
Oxidase Activity ◽  
Traumatic Injury ◽  
Traumatic Shock ◽  
Iron Release ◽  
Xanthine Oxidase Activity ◽  
Experimental Shock ◽  
Elevate Plasma

Two substances, 8-azaguanine (8AG) and 3, 3' -4, 4' -tetrahydroxy-chalcone (THC), believed to be nonoxidized in vivo inhibitors of xanthine oxidase in the rat, were used in an attempt to depress iron-release mechanisms during shock. Purine, a substrate of xanthine oxidase, was administered during shock as a means of stimulating these same mechanisms. No protection was obtained with 8AG and subsequent tests revealed that 8AG failed to depress the release of iron and uric acid both in shocked and untreated rats. The data point, instead, to inhibition of uricase by 8AG in the intact rat and not to inhibition of xanthine oxidase activity. Despite occasional depression of xanthine oxidase activity, THC exacerbated the course of traumatic shock in rats, possibly as a result of interference with pressor amine mechanisms. Purine loads were administered to normal rats and to rats primed with thorotrast. Although purine is known to elevate plasma iron in other species, rats treated with this metabolite were not unusually susceptible to lethal traumatic injury.

Xanthine Oxidase Activity in Vitro:  Effects of Food Extracts and Components

2005 ◽  
Vol 53 (16) ◽  
pp. 6510-6515 ◽  
Author(s):  
Tristan P. Dew ◽  
Andrea J. Day ◽  
Michael R. A. Morgan
Keyword(s):  
Xanthine Oxidase ◽  
Oxidase Activity ◽  
Xanthine Oxidase Activity ◽  
In Vitro Effects

scholarly journals Possible Association of Xanthine Dehydrogenase/Xanthine Oxidase Activity with Nitric Oxide in vivo

Nephron ◽  
1997 ◽  
Vol 75 (1) ◽  
pp. 123-124 ◽  
Author(s):  
Hirokazu Tsukahara ◽  
Masahiro Hiraoka ◽  
Chikahide Hori ◽  
Shinya Tsuchida ◽  
Koichiro Obata ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Xanthine Oxidase ◽  
Oxidase Activity ◽  
Xanthine Dehydrogenase ◽  
Xanthine Oxidase Activity
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