Terpenoids with neurotrophic and anti-neuroinflammatory activities from the cultures of the fungus Cyathus stercoreus

2020 ◽  
pp. 1-10 ◽  
Author(s):  
Xia Yin ◽  
Jianzhao Qi ◽  
Yixiao Li ◽  
Ze’an Bao ◽  
Peng Du ◽  
...  
Keyword(s):  
Cyathus Stercoreus

Variation in Fruit Bodies of Cyathus Stercoreus Produced in Culture

Mycologia ◽  
1948 ◽  
Vol 40 (5) ◽  
pp. 614-626 ◽  
Author(s):  
Harold J. Brodie
Keyword(s):  
Cyathus Stercoreus

Twin Fruit Bodies in a Slender-Stemmed Form of Cyathus stercoreus

Mycologia ◽  
1977 ◽  
Vol 69 (1) ◽  
pp. 199 ◽  
Author(s):  
Harold J. Brodie
Keyword(s):  
Cyathus Stercoreus

Biological delignification of plant components by the white rot fungi Ceriporiopsis subvermispora and Cyathus stercoreus

1996 ◽  
Vol 63 (1-4) ◽  
pp. 305-321 ◽  
Author(s):  
D.E. Akin ◽  
W.H. Morrison ◽  
L.L. Rigsby ◽  
G.R. Gamble ◽  
A. Sethuraman ◽  
...  
Keyword(s):  
White Rot Fungi ◽  
White Rot ◽  
Ceriporiopsis Subvermispora ◽  
Cyathus Stercoreus ◽  
Plant Components

scholarly journals Discovery of Fungal Metabolites Bergenin, Quercitrin and Dihydroartemisinin as Potential Inhibitors Against Main Protease of SARS-CoV-2

2020 ◽  
Author(s):  
Ravi Patel ◽  
Akash Vanzara ◽  
Nimisha Patel ◽  
Ajit Vasava ◽  
Sachin Patil ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Active Site ◽  
Electrostatic Interactions ◽  
Hydrophobic Interactions ◽  
Binding Energies ◽  
Crystallographic Structure ◽  
Medicinal Uses ◽  
Main Protease ◽  
Cyathus Stercoreus ◽  
Potential Inhibitors

Emergence of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection has given rise to COVID-19 pandemic, that is wreaking havoc worldwide. Therefore, there is an urgent need to find out novel drugs to combat SARS-CoV-2 infection. In this backdrop, the present study was aimed to assess potent bioactive compounds from different fungi as potential inhibitors of SARS-CoV-2 main protease (M<sup>pro</sup>) using an <i>in-silico</i> analysis. Nearly 118 bioactive compounds were extracted from <i>Dictyophora indusiata</i>, <i>Geassstrum triplex</i> and <i>Cyathus stercoreus </i>and identified using HR LC/MS analysis. Of which, only bergenin (<i>D. indusiata</i>), quercitrin (<i>G. triplex</i>) and dihydroartemisinin (<i>C. stercoreus</i>) were selected based on their medicinal uses, binding score and active site covered. The 6LU7, a protein crystallographic structure of SARS-CoV-2 M<sup>pro</sup>, was docked with bergenin, quercitrin and dihydroartemisinin using Autodock 4.2 and the binding energies obtained were -7.86, -10.29 and -7.20 kcal/mol, respectively. Bergenin, quercitrin and dihydroartemisinin formed hydrogen bond, electrostatic interactions and hydrophobic interactions with foremost active site amino acids THR190, GLU166, GLN189, GLY143, HIS163, HIS164, CYS145 and PHE140. Present investigation suggests that these three drugs may be used as alternative inhibitors against SARS-CoV-2 M<sup>pro</sup>. However, further research is necessary to assess <i>in vitro</i> potential of these drugs. To the best of our knowledge, present investigation reported these three bioactive compounds of fungal origin for the first time.

Sign in / Sign up

Export Citation Format

Share Document