New benzoic acid and caffeoyl derivatives with anti-inflammatory activities isolated from leaves of Ilex kaushue

2021 ◽  
pp. 1-9
Author(s):  
Yuya Kakumu ◽  
Thi Minh Tu Nguyen ◽  
Kosei Yamauchi ◽  
Tohru Mitsunaga
Keyword(s):  
Benzoic Acid ◽  
Anti Inflammatory ◽  
Caffeoyl Derivatives

STUDY OF SPECIFIC PHARMACOLOGICAL ACTIVITY OF SODIUM SALT (4-О-Β-GLUCOPYRANOSYLOXY)-BENZOIC ACID

2016 ◽  
Vol 78 (6-8) ◽  
Author(s):  
Smirnov Ivan ◽  
Murashko Tatyana ◽  
Ivanov Alex ◽  
Bondarev Alex ◽  
Udut Vladimir
Keyword(s):  
Benzoic Acid ◽  
Analgesic Activity ◽  
Sodium Salt ◽  
Analgesic Effect ◽  
Inflammatory Diseases ◽  
Peptic Ulcers ◽  
Chronic Inflammatory Diseases ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Chronic inflammatory diseases of various genesis are prevalent today. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain and inflammation, but their long-term use is associated with complications in the gastrointestinal tract, including peptic ulcers. We synthesized a molecule of sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid. This substance has diuretic and anti-inflammatory activities. It should be noted that most of NSAIDs has analgesic effect. In this connection, the aim of this study was to evaluate the analgesic activity of sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid. We studied analgesic effect in the test “acetic writhing”. Sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid significantly reduces the number of writhing by 14 units during the experiment, as an alternative criterion percent of animals with analgesia was 42.6%. Thus, in the test "acetic writhing" revealed the presence of the analgesic activity have developed drug average severity. 

Synthesis, Characterization, Antibacterial, Antifungal, Antioxidant and Anti-Inflammatory Actions of Novel β-Diketone Complex

2019 ◽  
Vol 35 (6) ◽  
pp. 1799-1804
Author(s):  
Sachin Govind Bibave ◽  
Anil E. Athare
Keyword(s):  
Benzoic Acid ◽  
Elemental Analysis ◽  
Bidentate Ligand ◽  
Transformation Reaction ◽  
Anti Inflammatory ◽  
Methyl Phenyl

β-diketone (βd) is prepared using the name reaction Baker-Venkataraman transformation reaction. In this present work, ester (c’) was prepared when 1-(2-Hydroxy-5-methyl-phenyl)-ethanone (a’) was treated with 4-Propoxy-benzoic acid (b’) at 0 °C to 10 °C. (c’) on Baker-Venkataraman transformation to give β-diketone ligand (L’) named as 1-(2-Hydroxy-5-methyl-phenyl)-3-(4-propoxy-phenyl)-propane-1,3-dione. Bidentate ligand (L’) treated with Cu (II) nitrate gives Cu (II) complex (CuL’). (L’) shows tautomerism, this tautomerism phenomenon was studied using FTIR and NMR. Because of enol serve as ligand (L’) in the synthesis of (CuL’). The prepared (L’) can be characterized by HR-MS, elemental analysis, 1H, 13C, DEPT, D2O exchange, FTIR. The antibacterial, antifungal, antioxidant, anti-inflammatory property of (CuL’) is studied.

scholarly journals IN VITRO ANTI-INFLAMMATORY ACTIVITY OF THE COMPONENTS OF AMOMUM TSAO-KO IN MURINE MACROPHAGE RAW 264.7 CELLS

2018 ◽  
Vol 15 (2) ◽  
pp. 26
Author(s):  
Chun Whan Choi ◽  
Ju Young Shin ◽  
Changon Seo ◽  
Seong Su Hong ◽  
Eun-Kyung Ahn ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Benzoic Acid ◽  
Inflammatory Activity ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Dependent Manner ◽  
Murine Macrophage ◽  
Etoh Extract ◽  
Anti Inflammatory

Background: Plants still remain the prime source of drugs for the treatment of inflammation and can provide leads for the development of novel anti-inflammatory agents. Material and methods: An in vitro bioassay guide revealed that the 80% ethanol (EtOH) extract of the whole plant, Amomum tsao-ko (Zingiberaceae), displayed anti-inflammatory activity after assessing its effects on murine macrophage RAW 264.7 cells. Result: Phytochemical study of the 80% EtOH extract of Amomum tsao-ko led to the isolation of eight compounds: 4-hydroxy-3-methoxy-benzoic acid (1), meso-hannokinol (2), (+)-hannokinol (3), coumaric acid (4), 4-hydroxy-benzoic acid (5), (+)-epicatechin (6), (-)-catechin (7), and myrciaphenone A (8). The results indicated that two of the isolated components, (+)-epicatechin (6) and (-)-catechin (7), inhibited the production of nitric oxide (NO) significantly in lipopolysaccharide treated RAW 264.7 cells. Conclusion: LPS-induced interleukin tumor necrosis factor-alpha (TNF-), IL-1β and IL-10 production was also decreased in a dose-dependent manner. In addition, western blot analysis revealed that (+)-epicatechin (6) and (-)-catechin (7) reduced the expression of inducible nitric oxide synthase and inhibited nuclear localization of nuclear factor kappa-B (NF-κB).

Anti-sickling, analgesic and anti-inflammatory properties of 3, 5-dimethoxy-4-hydroxy benzoic acid and 2, 3,4-trihydroxyacetophenone

Phytomedicine ◽  
2000 ◽  
Vol 7 (2) ◽  
pp. 105-110 ◽  
Author(s):  
K. Gamaniel ◽  
B.B. Samuel ◽  
D.S. Kapu ◽  
A. Samson ◽  
H. Wagner ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Anti Inflammatory

scholarly journals Synthesis, Characterization and evaluation of Anti-inflammatory and Analgesic activity of Benzothiazole derivatives

2014 ◽  
Vol 2 (03) ◽  
pp. 84-89 ◽  
Author(s):  
Abhay Kumar Verma ◽  
Alex Martin ◽  
Arun Kumar Singh
Keyword(s):  
Benzoic Acid ◽  
1H Nmr ◽  
Mass Spectroscopy ◽  
Analgesic Activity ◽  
Aromatic Aldehydes ◽  
Spectroscopic Methods ◽  
Schiff’S Bases ◽  
Benzothiazole Derivatives ◽  
Anti Inflammatory ◽  
Analgesic Activities

A parent benzothiazole nucleus was synthesized by para amino acetanilide, then it is subjected to treatment with various substituted aromatic aldehydes to get the corresponding Schiff’s bases followed by treatment with pthalic anhydride to form 2-(6- acetamidobenzo[d]thiazol-2-ylcarbamoyl)benzoic acid. The structures of synthesized compounds were confirmed by various spectroscopic methods such as IR, 1H NMR and mass spectroscopy. The products were evaluated for their anti-inflammatory and analgesic activities. Some of the compounds exhibited potent activities when compared with the standards.

INVESTIGATION OF NEW NSAIDS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF KIDNEY AND URINARY TRACT

2016 ◽  
Vol 78 (5-6) ◽  
Author(s):  
Murashko Tatyana ◽  
Ivanov Alexey ◽  
Smirnov Ivan ◽  
Bondarev Alex ◽  
Alexey Nemtsev ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
High Efficiency ◽  
Inflammatory Diseases ◽  
Pain Syndrome ◽  
Test Substance ◽  
Peptic Ulcers ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the world, primarily due to their high efficiency for the treatment of inflammatory induced pain syndrome. The main feature of NSAIDs is a combination of anti-inflammatory, analgesic, antipyretic, and anticoagulant properties. However, their long-term use is associated with side effects in the gastrointestinal tract including peptic ulcers and other. We developed and synthesized molecule of methyl (4-О-β-glucopyranosyloxy)-benzoic acid. The anti-inflammatory effect of methyl (4-О-β-glucopyranosyloxy)-benzoic acid evaluated using the carrageenan-induced hindpaw edema model. The study shows that the intragastrically administration of test substance to animals reduces inflammatory process.

CrystEngComm - Invitation to Submit Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems

CrystEngComm ◽  
2022 ◽  
Author(s):  
Yunping Zhoujin ◽  
Yuping Li ◽  
Mingtao Zhang ◽  
Sean R. Parkin ◽  
Ju Guo ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Salt Formation ◽  
Inflammatory Drug ◽  
Two Systems ◽  
Anti Inflammatory ◽  
Its Polymorphism ◽  
Amino Benzoic Acid

2-((2,6-Dichlorophenyl)amino)benzoic acid (2-DCABA), a potential non-steroidal anti-inflammatory drug and an analog of 2-((2,6-dimethylphenyl)amino)benzoic acid (HDMPA) was synthesized and its polymorphism was studied to investigate the effect of double Cl-CH3 exchange....

Sign in / Sign up

Export Citation Format

Share Document