scholarly journals Synthesis and evaluation of the anti-hepatitis B virus activity of 4′-Azido-thymidine analogs and 4′-Azido-2′-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent

2019 ◽  
Vol 39 (4) ◽  
pp. 518-529
Author(s):  
Kengo Onitsuka ◽  
Ryoh Tokuda ◽  
Nobuyo Kuwata-Higashi ◽  
Hiroki Kumamoto ◽  
Manabu Aoki ◽  
...  
1999 ◽  
Vol 332 (9) ◽  
pp. 327-330 ◽  
Author(s):  
El Sayed H. El Ashry ◽  
Adel A.-H. Abdel-Rahman ◽  
Nagwa Rashed ◽  
Hanaa A. Rasheed

Molecules ◽  
2012 ◽  
Vol 17 (7) ◽  
pp. 8633-8646 ◽  
Author(s):  
Lihua Ma ◽  
Jie Song ◽  
Yaqin Shi ◽  
Changmei Wang ◽  
Bin Chen ◽  
...  

2009 ◽  
Vol 19 (4) ◽  
pp. 165-176 ◽  
Author(s):  
Yuao Zhu ◽  
Maria Curtis ◽  
Xiaoping Qi ◽  
Michael D Miller ◽  
Katyna Borroto-Esoda

2008 ◽  
Vol 63 (9-10) ◽  
pp. 667-674 ◽  
Author(s):  
Farag A. El-Essawy ◽  
Wael A. El-Sayed ◽  
Sherif A. El-Kafrawy ◽  
Asmaa S. Morshedy ◽  
Adel-H. Abdel-Rahman

A number of 1,3,4-oxadiazole, 3 - 9, and 1,2,4-triazole derivatives, 13 - 15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a - c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a - e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some of these compounds showed high antiviral activity


2020 ◽  
Vol 14 (8) ◽  
pp. 294-299
Author(s):  
A. Mothana Ramzi ◽  
H. Arbab Ahmed ◽  
K. Parvez Mohammad ◽  
S. Al-Dosari Mohammed

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