Anti-Hepatitis B Virus Activity of New 1,2,4-Triazol-2-yl- and 1,3,4-Oxadiazol-2-yl-2-pyridinone Derivatives

2008 ◽  
Vol 63 (9-10) ◽  
pp. 667-674 ◽  
Author(s):  
Farag A. El-Essawy ◽  
Wael A. El-Sayed ◽  
Sherif A. El-Kafrawy ◽  
Asmaa S. Morshedy ◽  
Adel-H. Abdel-Rahman
Keyword(s):  
Sulfuric Acid ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Alkylating Agents ◽  
Acid Hydrazide ◽  
Virus Activity ◽  
B Virus ◽  
Thiadiazole Derivative ◽  
High Antiviral Activity

A number of 1,3,4-oxadiazole, 3 - 9, and 1,2,4-triazole derivatives, 13 - 15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a - c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a - e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some of these compounds showed high antiviral activity

Anti-Hepatitis B Virus Activity of New N4-β-D-Glycoside Pyrazolo[3,4-d]pyrimidine Derivatives

2009 ◽  
Vol 64 (5-6) ◽  
pp. 323-328 ◽  
Author(s):  
Wael A. El-Sayed ◽  
Mahmoud M. M. Ramiz ◽  
Adel A.-H. Abdel-Rahman
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Acetic Anhydride ◽  
Pyrimidine Derivatives ◽  
Virus Activity ◽  
B Virus

1The reaction of 6-hydrazinyl-1,3-dimethylpyrimidine-2,4-(1H,3H)-dione () with ethoxymethylenemalononitrile afforded 5-amino-1-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin- 6-yl)-1H-pyrazole-4-carbonitrile (2). The latter was reacted with formamide and urea affording the corresponding 4-aminopyrazolo[3,4-d]pyrimidines 3 and 4. The reaction of monosaccharide aldoses with 3 and 4 gave stereoselectively the β-N-glycosides 5a - d and 6a - d which were treated with acetic anhydride in pyridine to afford the corresponding acetylated derivatives 7a - d and 8a - d. The prepared compounds were tested for their antiviral activity against hepatitis B virus (HBV) and showed moderate to high activities

scholarly journals Possible role of tocopherols in the modulation of host microRNA with potential antiviral activity in patients with hepatitis B virus-related persistent infection: a systematic review

2014 ◽  
Vol 112 (11) ◽  
pp. 1751-1768 ◽  
Author(s):  
S. Fiorino ◽  
L. Bacchi-Reggiani ◽  
S. Sabbatani ◽  
F. Grizzi ◽  
L. di Tommaso ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Hbv Infection ◽  
Cochrane Library ◽  
Viral Pathogen ◽  
Increased Risk ◽  
B Virus ◽  
Chronic Hbv

Hepatitis B virus (HBV) infection represents a serious global health problem and persistent HBV infection is associated with an increased risk of cirrhosis, hepatocellular carcinoma and liver failure. Recently, the study of the role of microRNA (miRNA) in the pathogenesis of HBV has gained considerable interest as well as new treatments against this pathogen have been approved. A few studies have investigated the antiviral activity of vitamin E (VE) in chronic HBV carriers. Herein, we review the possible role of tocopherols in the modulation of host miRNA with potential anti-HBV activity. A systematic research of the scientific literature was performed by searching the MEDLINE, Cochrane Library and EMBASE databases. The keywords used were ‘HBV therapy’, ‘HBV treatment’, ‘VE antiviral effects’, ‘tocopherol antiviral activity’, ‘miRNA antiviral activity’ and ‘VE microRNA’. Reports describing the role of miRNA in the regulation of HBV life cycle,in vitroandin vivoavailable studies reporting the effects of VE on miRNA expression profiles and epigenetic networks, and clinical trials reporting the use of VE in patients with HBV-related chronic hepatitis were identified and examined. Based on the clinical results obtained in VE-treated chronic HBV carriers, we provide a reliable hypothesis for the possible role of this vitamin in the modulation of host miRNA profiles perturbed by this viral pathogen and in the regulation of some cellular miRNA with a suggested potential anti-HBV activity. This approach may contribute to the improvement of our understanding of pathogenetic mechanisms involved in HBV infection and increase the possibility of its management and treatment.

Synthesis and Anti-Hepatitis B Virus Activity of Some 2,3-Dihydroxyprop-1-yl Unnatural Hetaryls

1999 ◽  
Vol 332 (9) ◽  
pp. 327-330 ◽  
Author(s):  
El Sayed H. El Ashry ◽  
Adel A.-H. Abdel-Rahman ◽  
Nagwa Rashed ◽  
Hanaa A. Rasheed
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Activity ◽  
B Virus

scholarly journals Anti-Hepatitis B Virus Activity of Chickweed [Stellaria media (L.) Vill.] Extracts in HepG2.2.15 Cells

Molecules ◽  
2012 ◽  
Vol 17 (7) ◽  
pp. 8633-8646 ◽  
Author(s):  
Lihua Ma ◽  
Jie Song ◽  
Yaqin Shi ◽  
Changmei Wang ◽  
Bin Chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Stellaria Media ◽  
Virus Activity ◽  
B Virus

Anti-Hepatitis B Virus Activity in Vitro of Combinations of Tenofovir with Nucleoside/nucleotide Analogues

2009 ◽  
Vol 19 (4) ◽  
pp. 165-176 ◽  
Author(s):  
Yuao Zhu ◽  
Maria Curtis ◽  
Xiaoping Qi ◽  
Michael D Miller ◽  
Katyna Borroto-Esoda
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleotide Analogues ◽  
Virus Activity ◽  
B Virus

scholarly journals Smc5/6-antagonism by HBx is an evolutionary-conserved function of hepatitis B virus infection in mammals

2017 ◽  
Author(s):  
Fabien Filleton ◽  
Fabien Abdul ◽  
Laetitia Gerossier ◽  
Alexia Paturel ◽  
Janet Hall ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Positive Selection ◽  
Host Species ◽  
Human Hepatocytes ◽  
Arms Race ◽  
Restriction Factor ◽  
Primary Human Hepatocytes ◽  
B Virus

AbstractInfection with Hepatitis B virus (HBV) is a major cause of liver disease and cancer in humans. HBVs (family Hepadnaviridae) have been associated with mammals for millions of years. Recently, the Smc5/6 complex, known for its essential housekeeping functions in genome maintenance, was identified as an antiviral restriction factor of human HBV. The virus has however developed a counteraction mechanism by degrading the complex via its regulatory HBx protein. Whether the antiviral activity of the Smc5/6 complex against hepadnaviruses is an important and evolutionary-conserved function is unknown. Here, we used a combined evolutionary and functional approach to address this question. We first performed phylogenetic and positive selection analyses of the six Smc5/6 complex subunits and found that they have been highly conserved in primates and mammals. Yet, the Smc6 subunit showed marks of adaptive evolution, potentially reminiscent of virus-host “arms-race” We then functionally tested the HBx from six very divergent hepadnaviruses now naturally infecting primates, rodents, and bats. Despite little sequence homology, we demonstrate that these HBx efficiently degraded mammalian Smc5/6 complexes, independently of the host species and of the sites under positive selection. Importantly, all also rescued the replication of an HBx-deficient HBV in primary human hepatocytes. These findings point to an evolutionary-conserved requirement for Smc5/6 inactivation by HBx, showing that the Smc5/6 antiviral activity has been an important defense mechanism against hepadnaviruses in mammals. Interestingly, Smc5/6 may further be a restriction factor of other yet unidentified viruses that have driven some of its adaptation.ImportanceInfection with hepatitis B virus (HBV) led to 887000 human deaths in 2015. HBV has been co-evolving with mammals for millions of years. Recently, the Smc5/6 complex, known for its essential housekeeping functions, was identified as a restriction factor of human HBV antagonized by the regulatory HBx protein. Here, we address whether the antiviral activity of Smc5/6 is an important evolutionary-conserved function. We found that all six subunits of Smc5/6 have been conserved in primates with only Smc6 showing signatures of “evolutionary arms-race” Using evolutionary-guided functional assays that include infections of primary human hepatocytes, we demonstrate that HBx from very divergent mammalian HBVs could all efficiently antagonize Smc5/6, independently of the host species and sites under positive selection. These findings show that the Smc5/6 antiviral activity against HBV is an important function in mammals. It also raises the intriguing possibility that Smc5/6 restricts other, yet unidentified viruses.

Antiviral activity of Bifidobacterium adolescentis SPM0212 against Hepatitis B virus

2013 ◽  
Vol 36 (12) ◽  
pp. 1525-1532 ◽  
Author(s):  
Do Kyung Lee ◽  
Joo Yeon Kang ◽  
Hea Soon Shin ◽  
Il Ho Park ◽  
Nam Joo Ha
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Bifidobacterium Adolescentis ◽  
B Virus

Antiviral activity of 5′-O-carbonate-2′,3′-dideoxy-3′-thiacytidine prodrugs against hepatitis B virus in HepG2 2.2.15 cells

2010 ◽  
Vol 36 (6) ◽  
pp. 566-569 ◽  
Author(s):  
Dolores Gagey ◽  
Soledad Ravetti ◽  
Eliana F. Castro ◽  
María Soledad Gualdesi ◽  
Margarita C. Briñon ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
B Virus ◽  
Hepg2 2.2.15
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