Effects of extremely low-frequency pulsed electromagnetic fields (ELF-PEMFs) on glioblastoma cells (U87)

2016 ◽  
Vol 36 (3) ◽  
pp. 238-247 ◽  
Author(s):  
Zeinab Akbarnejad ◽  
Hossein Eskandary ◽  
Cristian Vergallo ◽  
Seyed Noureddin Nematollahi-Mahani ◽  
Luciana Dini ◽  
...  
2019 ◽  
Vol 8 (12) ◽  
pp. 2028 ◽  
Author(s):  
Sabrina Ehnert ◽  
Steffen Schröter ◽  
Romina H. Aspera-Werz ◽  
Wiebke Eisler ◽  
Karsten Falldorf ◽  
...  

The finding that alterations in electrical potential play an important role in the mechanical stimulation of the bone provoked hype that noninvasive extremely low frequency pulsed electromagnetic fields (ELF-PEMF) can be used to support healing of bone and osteochondral defects. This resulted in the development of many ELF-PEMF devices for clinical use. Due to the resulting diversity of the ELF-PEMF characteristics regarding treatment regimen, and reported results, exposure to ELF-PEMFs is generally not among the guidelines to treat bone and osteochondral defects. Notwithstanding, here we show that there is strong evidence for ELF-PEMF treatment. We give a short, confined overview of in vitro studies investigating effects of ELF-PEMF treatment on bone cells, highlighting likely mechanisms. Subsequently, we summarize prospective and blinded studies, investigating the effect of ELF-PEMF treatment on acute bone fractures and bone fracture non-unions, osteotomies, spinal fusion, osteoporosis, and osteoarthritis. Although these studies favor the use of ELF-PEMF treatment, they likewise demonstrate the need for more defined and better controlled/monitored treatment modalities. However, to establish indication-oriented treatment regimen, profound knowledge of the underlying mechanisms in the sense of cellular pathways/events triggered is required, highlighting the need for more systematic studies to unravel optimal treatment conditions.


2016 ◽  
Vol 98 ◽  
pp. 146-158 ◽  
Author(s):  
Marisa Cornacchione ◽  
Manuela Pellegrini ◽  
Lorenzo Fassina ◽  
Maria Evelina Mognaschi ◽  
Sara Di Siena ◽  
...  

Nitric Oxide ◽  
2019 ◽  
Vol 92 ◽  
pp. 49-54 ◽  
Author(s):  
Ayse Demirkazik ◽  
Ercan Ozdemir ◽  
Gökhan Arslan ◽  
Ahmet Sevki Taskiran ◽  
Aykut Pelit

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