Morphology and Photophysical Properties of One-Dimensional Arrayed Porphyrin Aggregates Assisted by Cyclodextrin Inclusion Complexation

2012 ◽  
Vol 566 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Shigeaki Abe ◽  
Hirohisa Kobayashi ◽  
Takayuki Kiba ◽  
Fumio Watari ◽  
Shin-Ichiro Sato
Keyword(s):  
Photophysical Properties ◽  
Inclusion Complexation ◽  
One Dimensional ◽  
Cyclodextrin Inclusion

Photophysical Properties of Self-assembled Cyanine-dye Dimmer Formation Assisted by Cyclodextrin Inclusion Complexation

2013 ◽  
Vol 579 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Shigeaki Abe ◽  
Takashi Hirota ◽  
Takayuki Kiba ◽  
Naoyuki Miyakawa ◽  
Fumio Watari ◽  
...  
Keyword(s):  
Photophysical Properties ◽  
Inclusion Complexation ◽  
Cyanine Dye ◽  
Cyclodextrin Inclusion ◽  
Self Assembled

Solvent-Dependent Photophysical Properties of a Semiconducting One-Dimensional Silver Cluster-Assembled Material

2021 ◽  
Author(s):  
Anish Kumar Das ◽  
Sourav Biswas ◽  
Surya Sekhar Manna ◽  
Biswarup Pathak ◽  
Sukhendu Mandal
Keyword(s):  
Photophysical Properties ◽  
Silver Cluster ◽  
One Dimensional

Cyclodextrin Inclusion of Medicinal Compounds for Enhancement of their Physicochemical and Biopharmaceutical Properties

2019 ◽  
Vol 19 (25) ◽  
pp. 2357-2370 ◽  
Author(s):  
Mino R. Caira
Keyword(s):  
Drug Discovery ◽  
Inclusion Complexation ◽  
Structural Diversity ◽  
Attrition Rate ◽  
Cyclodextrin Inclusion ◽  
Biopharmaceutical Properties ◽  
Fine Tune ◽  
Early Drug ◽  
Selection Of

Owing to their wide structural diversity and unique complexing properties, cyclodextrins (CDs) find manifold applications in drug discovery and development. The focus of this mini-review is on their uses as ‘enabling excipients’ both in the context of early drug discovery and in subsequent optimisation of drug performance. Features highlighted here include descriptions of the structures of CDs, synthetic derivatisation to fine-tune their properties, the nature of inclusion complexation of drugs within the CD cavity, methodology for the study of free and complexed hosts in the solid state and in solution, the inherent pharmacological activity of several CDs and its utility, novel CD-based drug delivery systems, and the role of CDs in drug discovery and optimisation. Illustrative examples are generally based on research reported during the last two decades. Application of CDs to the optimisation of the performance of established drugs is commonplace, but there are many opportunities for the intervention of CDs during the early stages of drug discovery, which could guide the selection of suitable candidates for development, thereby contributing to reducing the attrition rate of new molecular entities.

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