Studies on phase diagram, thermodynamic stability and interfacial structure of solid dispersions of phenothiazine-adipic acid drug system

2019 ◽  
Vol 689 (1) ◽  
pp. 60-71
Author(s):  
H. Shekhar ◽  
Manoj Kumar
Keyword(s):  
Phase Diagram ◽  
Adipic Acid ◽  
Thermodynamic Stability ◽  
Solid Dispersions ◽  
Interfacial Structure

Interfacial Structure Analysis for the Morphology Prediction of Adipic Acid Crystals from Aqueous Solution

2017 ◽  
Vol 17 (3) ◽  
pp. 1088-1095 ◽  
Author(s):  
Bumjoon Seo ◽  
Taewan Kim ◽  
Seulwoo Kim ◽  
Ji Ho Ryu ◽  
Jebin Ryu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Structure Analysis ◽  
Adipic Acid ◽  
Interfacial Structure

Theoretical Prediction of a Phase Diagram for Solid Dispersions

2014 ◽  
Vol 32 (3) ◽  
pp. 840-851 ◽  
Author(s):  
Bin Tian ◽  
Xiaoyan Wang ◽  
Yuanyuan Zhang ◽  
Keru Zhang ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Phase Diagram ◽  
Theoretical Prediction ◽  
Solid Dispersions

scholarly journals Analysis of Solid-State Interactions of Ketoprofen-Coformer Binary Mixtures by DSC and Hot Stage Microscopy

Molekul ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. 121
Author(s):  
Yudi Wicaksono ◽  
Dwi Setyawan ◽  
Siswandono Siswandono
Keyword(s):  
Phase Diagram ◽  
Liquid Phase ◽  
Adipic Acid ◽  
Water Solubility ◽  
Molar Fraction ◽  
Eutectic System ◽  
Scanning Calorimetry ◽  
Hot Stage Microscopy ◽  
Solid Form ◽  
Solid Liquid

Ketoprofen is a non-steroidal anti-inflammatory drug with poor water solubility, so the absorption is less than optimal. One method to improve the solubility of ketoprofen is through the formation of multicomponent solid forms. The success of the formation of the multicomponent solid forms is strongly influenced by interactions between components in their solids. In this study, the analysis of the interactions in solid form of ketoprofen-coformers was carried out using the differential scanning calorimetry (DSC) and hot stage microscopy (HSM) with adipic acid and isonicotinamide as coformers. From the experimental results, the mixtures of ketoprofen-adipic acid show a solid-liquid phase diagram that indicates a simple eutectic system with eutectic points on the molar fraction of ketoprofen 0.9 and temperature at 92.9 °C. The ketoprofen-isonicotinamide mixtures have a eutectic system with the peritectic point. The solid-liquid phase diagram has indicated that the ketoprofen-adipic acid in eutectic composition forms a miscible liquid phase without interaction in its solid form, whereas the ketoprofen-isonicotinamide forms a miscible liquid phase accompanied by interaction with the excess component. The results of the HSM analysis showed the same phenomenon as the result of the DSC experiment and have confirmed with the FTIR analysis

Thermodynamic stability of the superconducting phase diagram of UPt3

1993 ◽  
Vol 93 (1-2) ◽  
pp. 101-116 ◽  
Author(s):  
N. H. van Dijk ◽  
A. de Visser ◽  
J. J. M. Franse ◽  
L. Taillefer
Keyword(s):  
Phase Diagram ◽  
Thermodynamic Stability ◽  
Superconducting Phase
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