Application of a newly-developed cynomolgus macaque BiTE-mediated cytotoxic T-lymphocyte activity assay to various immunomodulatory agents in vitro

Brendon Frank; Hao Guo; Hervé Lebrec; Xiaoting Wang

doi:10.1080/1547691x.2021.1992687

Application of a newly-developed cynomolgus macaque BiTE-mediated cytotoxic T-lymphocyte activity assay to various immunomodulatory agents in vitro

Journal of Immunotoxicology ◽

10.1080/1547691x.2021.1992687 ◽

2021 ◽

Vol 18 (1) ◽

pp. 154-162

Author(s):

Brendon Frank ◽

Hao Guo ◽

Hervé Lebrec ◽

Xiaoting Wang

Keyword(s):

T Lymphocyte ◽

Cytotoxic T Lymphocyte ◽

Cynomolgus Macaque ◽

Activity Assay ◽

Immunomodulatory Agents ◽

Lymphocyte Activity

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Development of a BiTE®-mediated CD8+ cytotoxic T-lymphocyte activity assay to assess immunomodulatory potential of drug candidates in Cynomolgus macaque

Journal of Immunotoxicology ◽

10.1080/1547691x.2018.1486342 ◽

2018 ◽

Vol 15 (1) ◽

pp. 119-125 ◽

Cited By ~ 1

Author(s):

Brendon Frank ◽

Yu-Ling Wei ◽

Kyung-Hoon Kim ◽

Abraham Guerrero ◽

Hervé Lebrec ◽

...

Keyword(s):

T Lymphocyte ◽

Cytotoxic T Lymphocyte ◽

Cynomolgus Macaque ◽

Activity Assay ◽

Drug Candidates ◽

Lymphocyte Activity ◽

Immunomodulatory Potential

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Impaired cytotoxic T lymphocyte activity in systemic lupus erythematosus following in vitro polyclonal T cell stimulation: a contributory role for non-T cells

Lupus ◽

10.1191/096120399678847768 ◽

1999 ◽

Vol 8 (4) ◽

pp. 293-299 ◽

Cited By ~ 7

Author(s):

W Stohl ◽

A S Hamilton ◽

D M Deapen ◽

T M Mack ◽

D A Horwitz

Keyword(s):

Systemic Lupus Erythematosus ◽

T Cells ◽

T Cell ◽

T Lymphocyte ◽

Lupus Erythematosus ◽

Cytotoxic T Lymphocyte ◽

Systemic Lupus ◽

T Cell Stimulation ◽

Lymphocyte Activity

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Deoxyspergualin, a novel immunosuppressant, markedly inhibits human mixed lymphocyte reaction and cytotoxic T-lymphocyte activity in vitro

International Journal of Immunopharmacology ◽

10.1016/0192-0561(92)90136-9 ◽

1992 ◽

Vol 14 (4) ◽

pp. 731-737 ◽

Cited By ~ 25

Author(s):

Hideji Fujii ◽

Teruyo Takada ◽

Kyuichi Nemoto ◽

Fuminori Abe ◽

Akio Fujii ◽

...

Keyword(s):

T Lymphocyte ◽

Mixed Lymphocyte Reaction ◽

Cytotoxic T Lymphocyte ◽

Lymphocyte Activity

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Use of a High-Affinity Peptide That Aborts MHC-Restricted Cytotoxic T Lymphocyte Activity against Multiple Viruses in Vitro and Virus-Induced Immunopathologic Disease in Vivo

Virology ◽

10.1006/viro.1998.9593 ◽

1999 ◽

Vol 256 (2) ◽

pp. 246-257 ◽

Cited By ~ 14

Author(s):

Michael B.A. Oldstone ◽

Matthias von Herrath ◽

Hanna Lewicki ◽

Denis Hudrisier ◽

J.Lindsay Whitton ◽

...

Keyword(s):

T Lymphocyte ◽

Cytotoxic T Lymphocyte ◽

High Affinity ◽

Lymphocyte Activity ◽

Affinity Peptide

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Dendritic cells, generated in vitro, are immunocompetent and very useful in the induction of specific cytotoxic T lymphocyte activity

Transplantation Proceedings ◽

10.1016/s0041-1345(01)02614-8 ◽

2001 ◽

Vol 33 (7-8) ◽

pp. 3814-3815 ◽

Cited By ~ 1

Author(s):

T Hasel ◽

R Yoshimura ◽

S Wada ◽

J Chargui

Keyword(s):

Dendritic Cells ◽

T Lymphocyte ◽

Cytotoxic T Lymphocyte ◽

Lymphocyte Activity

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Suppression of cytotoxic T lymphocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin occurs in vivo, but not in vitro, and is independent of corticosterone elevation

Toxicology ◽

10.1016/0300-483x(94)02929-o ◽

1995 ◽

Vol 97 (1-3) ◽

pp. 105-112 ◽

Cited By ~ 22

Author(s):

Gregory K. De Krey ◽

Nancy I. Kerkvliet

Keyword(s):

T Lymphocyte ◽

Cytotoxic T Lymphocyte ◽

Lymphocyte Activity ◽

Tetrachlorodibenzo P Dioxin

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Ubiquitin-modified hepatitis B virus core antigen effectively facilitates antigen presentation and enhances cytotoxic T lymphocyte activity via the cytoplasmic transduction peptide in vitro

Molecular Medicine Reports ◽

10.3892/mmr.2015.3352 ◽

2012 ◽

Vol 12 (1) ◽

pp. 289-296 ◽

Cited By ~ 2

Author(s):

LINLIN SONG ◽

MENG ZHUO ◽

YUYAN TANG ◽

XIAOHUA CHEN ◽

YONGSHENG YU ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Antigen Presentation ◽

T Lymphocyte ◽

Cytotoxic T Lymphocyte ◽

Core Antigen ◽

Virus Core ◽

B Virus ◽

Lymphocyte Activity

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Unconjugated bilirubin inhibits in vitro cytotoxic T lymphocyte activity of human lymphocytes

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ◽

10.1016/0925-4439(96)00039-7 ◽

1996 ◽

Vol 1317 (1) ◽

pp. 65-70 ◽

Cited By ~ 29

Author(s):

Yoshio Haga ◽

Margaret A. Tempero ◽

Rowen K. Zetterman

Keyword(s):

T Lymphocyte ◽

Cytotoxic T Lymphocyte ◽

Human Lymphocytes ◽

Unconjugated Bilirubin ◽

Lymphocyte Activity

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Limited importance of CD40/CD40L interaction in the B7-dependent generation of anti-MOPC-315 cytotoxic T lymphocyte activity by tumor bearer splenic cells stimulated in vitro in the presence of tumor necrosis factor

Cancer Immunology Immunotherapy ◽

10.1007/s002620050490 ◽

1998 ◽

Vol 46 (6) ◽

pp. 293-303 ◽

Cited By ~ 2

Author(s):

Tatiana V. Kalinichenko ◽

M. B. Mokyr

Keyword(s):

Tumor Necrosis Factor ◽

T Lymphocyte ◽

Tumor Necrosis ◽

Cytotoxic T Lymphocyte ◽

Splenic Cells ◽

Lymphocyte Activity ◽

Tumor Bearer ◽

Necrosis Factor

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The Generation, Detection and Characterization of Cytotoxic T Lymphocyte Activity in Vitro

Scandinavian Journal of Immunology ◽

10.1111/j.1365-3083.1976.tb03864.x ◽

1976 ◽

Vol 5 ◽

pp. 135-142 ◽

Cited By ~ 2

Author(s):

HOWARD D. ENGERS ◽

H. ROBSON MACDONALD

Keyword(s):

T Lymphocyte ◽

Cytotoxic T Lymphocyte ◽

Lymphocyte Activity

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