Influence of serum 25-hydroxyvitamin D on the rate of pain episodes in Nigerian children with sickle cell anaemia

2017 ◽  
Vol 37 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Samuel Ademola Adegoke ◽  
Oyeku Akibu Oyelami ◽  
Adekunle Adekile ◽  
Maria Stella Figueiredo
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Hydroxyvitamin D ◽  
Nigerian Children ◽  
25 Hydroxyvitamin D

scholarly journals Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Bankole Peter Kuti ◽  
Alex Ifeoluwa Akinwumi ◽  
Demilade Kehinde Kuti ◽  
Kazeem Olanrewaju Amoo
Keyword(s):  
Vitamin D ◽  
Total Antioxidant Capacity ◽  
Serum Vitamin ◽  
Severe Pneumonia ◽  
Lower Serum ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Nigerian Children ◽  
Total Antioxidant ◽  
25 Hydroxyvitamin D

Abstract Background The pathologic basis of childhood community-acquired pneumonia (CAP) involves the generation of reactive oxygen species by immune cells leading to cellular damage and lung congestion. Serum antioxidants and vitamin D with immunomodulatory properties therefore hold prospects in the prevention and management of pneumonia in children. This case–control study set out to compare the serum 25-hydroxyvitamin D (25-OHD) and total antioxidant capacity (TAC) in Nigerian children with CAP and age- and sex-matched controls and to relate these parameters with pneumonia severity and outcome—length of hospital stay (LOH). Results A total of 160 children (80 each for CAP and controls) were recruited. The median (IQR) age was 1.8 (0.6–4.0) years, male:female 1.7:1, 63 (78.8%) and 11 (13.8%) of CAP group had severe pneumonia and parapneumonic effusions, respectively. Serum 25-OHD (33.8 (18.3) ng/ml vs. 41.9 (12.3) ng/ml; p = 0.010) and TAC (6.1 (4.4–8.1) ng/dl vs. 7.2 (4.7–17.5) ng/dl; p = 0.023) were lower in children with CAP than controls. Lower serum 25-OHD was observed in severe than non-severe pneumonia (30.5(17.1) ng/ml vs. 46.3 (17.6) ng/ml; p = 0.001) but LOH did not correlate with serum 25-OHD and TAC. Conclusion Children with CAP had lower serum vitamin D and antioxidants than controls, and severe pneumonia was significantly associated with suboptimal serum vitamin D. They however were not related to pneumonia outcome. Optimal serum vitamin D and antioxidants may play a role in reducing the incidence of childhood CAP in Nigerian children.

Liver function test profile of Nigerian children with sickle cell anaemia in steady state

2014 ◽  
Vol 11 (1) ◽  
pp. 13
Author(s):  
ShehuA Akuyam ◽  
PeterO Anaja ◽  
Yusuf Garba ◽  
Nasir Lawal ◽  
Abdullahi Musa ◽  
...  
Keyword(s):  
Steady State ◽  
Liver Function ◽  
Liver Function Test ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Nigerian Children ◽  
Function Test

Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease

2018 ◽  
Vol 40 (4) ◽  
pp. e243-e247 ◽  
Author(s):  
Samuel A. Adegoke ◽  
Josefina A.P. Braga ◽  
Adekunle D. Adekile ◽  
Maria S. Figueiredo
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Predicted Reference Equations for Spirometry Indices as a Proxy from Anthropometry Measurements of Nigerian Children with Sickle Cell Anaemia Aged 5–12 Years

2020 ◽  
Author(s):  
Olufemi S Akodui ◽  
Abiodun O Faleti ◽  
Folashade A Adekanmbi ◽  
Tinuade A Ogunlesi
Keyword(s):  
Sickle Cell ◽  
Standard Error ◽  
Sickle Cell Anaemia ◽  
Prediction Models ◽  
Coefficient Of Determination ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Nigerian Children ◽  
Arm Span ◽  
Reference Equations

Abstract Background Significant morbidity and mortality in patients with sickle cell disease are accounted for by lung complications. To facilitate good respiratory care for children with sickle cell anaemia the generation of local predicted values is highly important. Objective To determine the reference equations for spirometry indices estimation in children with sickle cell anaemia, which can be readily used as proxy when there is no easy accessibility to spirometer. Methods A cross-sectional study with linear regression models developed to estimate reference values for spirometric indices in Nigerian children with sickle cell anaemia aged 5–12 years. Results Age as independent variables for estimation of forced expiratory volume in 1 s (FEV1) was associated with lowest coefficient of determination (R2) and highest standard error. The coefficient of determination (R2) and standard error was highest and lowest, respectively, when arm span was used to determine peak expiratory flow rate (PEFR). Prediction models for PEFR and FEV1 gave the closest mean estimates that were 0.18 and 0.16 lower and higher than the actual mean PEFR and FEV1, respectively, but the differences was significant only in FEV1. On the contrary the prediction models for forced vital capacity (FVC) gave mean estimates that was 1.02 higher than the actual mean FVC, however, the finding was not significant. Conclusion Preferred proxy for spirometry indices in children with sickle cell anaemia may be arm span.

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