Cognitive functions in children and adolescents with early-onset diabetes mellitus in Egypt

2016 ◽  
Vol 7 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Mohamed Abo-el-Asrar ◽  
Nevine G. Andrawes ◽  
Menan A. Rabie ◽  
Dina Aly El-Gabry ◽  
Abdel-Gawad Khalifa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Cognitive Functions ◽  
Early Onset ◽  
Onset Diabetes

A case of novel de novo paired box gene 6 (PAX6) mutation with early-onset diabetes mellitus and aniridia

2005 ◽  
Vol 22 (5) ◽  
pp. 641-644 ◽  
Author(s):  
M. Nishi ◽  
M. Sasahara ◽  
T. Shono ◽  
S. Saika ◽  
Y. Yamamoto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Early Onset ◽  
De Novo ◽  
Onset Diabetes ◽  
Pax6 Mutation

Early onset diabetes mellitus. Tip or iceberg?

2004 ◽  
Vol 5 (4) ◽  
pp. 171-173 ◽  
Author(s):  
Constantin Polychronakos
Keyword(s):  
Diabetes Mellitus ◽  
Early Onset ◽  
Onset Diabetes

Mutations of maturity-onset diabetes of the young (MODY) genes in Thais with early-onset type 2 diabetes mellitus

2009 ◽  
Vol 70 (6) ◽  
pp. 847-853 ◽  
Author(s):  
Nattachet Plengvidhya ◽  
Watip Boonyasrisawat ◽  
Nalinee Chongjaroen ◽  
Prapaporn Jungtrakoon ◽  
Sutin Sriussadaporn ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Early Onset ◽  
Maturity Onset Diabetes ◽  
Onset Type ◽  
Onset Diabetes

Dermatoglyphics in Early-Onset Diabetes Mellitus

1973 ◽  
Vol 23 (6) ◽  
pp. 535-542 ◽  
Author(s):  
Julian L. Verbov
Keyword(s):  
Diabetes Mellitus ◽  
Early Onset ◽  
Onset Diabetes

scholarly journals Early-Onset Diabetes Mellitus in a Patient With a Chromosome 13q34qter Microdeletion Including IRS2

2018 ◽  
Vol 2 (10) ◽  
pp. 1207-1213 ◽  
Author(s):  
Naru Babaya ◽  
Shinsuke Noso ◽  
Yoshihisa Hiromine ◽  
Hiroyuki Ito ◽  
Yasunori Taketomo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Early Onset ◽  
Onset Diabetes

scholarly journals A novel splice-site mutation of the HNF1B gene in a family with maturity onset diabetes of the young type 5 (MODY5)

2020 ◽  
Vol 2020 ◽  
Author(s):  
Yuki Fujita ◽  
Daisuke Tanaka ◽  
Hisato Tatsuoka ◽  
Miho Matsubara ◽  
Takanori Hyo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Splice Site ◽  
Early Onset ◽  
Genetic Diagnosis ◽  
Splice Site Mutation ◽  
Maturity Onset Diabetes ◽  
Site Mutation ◽  
Renal Anomalies ◽  
Onset Diabetes ◽  
Appropriate Treatment

Summary Maturity-onset diabetes of the young (MODY) is a form of monogenic diabetes mellitus characterised by early onset and dominant inheritance. Delayed diagnosis or misdiagnosis as type 1 or type 2 diabetes mellitus is common. Definitive genetic diagnosis is essential for appropriate treatment of patients with MODY. The hepatocyte nuclear factor 1-beta (HNF1B) gene is responsible for MODY type 5 (MODY5), which has distinctive clinical features including renal disease. MODY5 should always be considered by clinicians in patients with early onset diabetes and renal anomalies. We report a case of a 30-year-old Japanese male with early-onset diabetes mellitus, renal anomalies and family history of diabetes that was suggestive of MODY5. Renal histology showed no evidence of diabetic nephropathy. Genetic testing revealed a novel heterozygous splice-site mutation of the HNF1B gene in the family members. It was strongly suggested that the mutation could underlie our patient’s MODY5. Learning points: Genetic diagnosis of MODY is relevant for appropriate treatment. Dominantly inherited early-onset diabetes mellitus with renal cysts suggests MODY5. Scanning the non-coding regions is important for not missing a mutation in HNF1B.

Neonatal and very-early-onset diabetes mellitus

2004 ◽  
Vol 9 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Michel Polak ◽  
Julian Shield
Keyword(s):  
Diabetes Mellitus ◽  
Early Onset ◽  
Onset Diabetes
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