Dynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules

In recent years, impressive advances in the knowledge about a vast number of microbes living in the human body and interactions between the microbiota and the human body have been observed. All micro-organisms that live in the human body consist of around 10 ^ 14 cells. The number of microbial cells colonizing the human body is ten times higher than the number of its own cells and the weight of all micro-organisms is about 2-2.5 kg. The number of bacterial genes is 50-100 times greater than the number of genes in the human body. Nowadays, the human microbiota is often regarded as a “newly discovered organ” or even as a “supergenome”. The results of many studies have revealed that disruption of the bowel microecosystem may affect the development of irritable bowel syndrome (IBS) symptoms. Therefore, manipulation of the gut microflora was hoped to be a new tool in the treatment of this disease. Various methods (probiotics, prebiotics, antibiotic therapy, transplantation of faecal flora) have been used to modify the intestinal microbiota by supporting the expansion of bacteria considered beneficial and reducing the number of those regarded as harmful, thus alleviating the IBS symptoms. There is much evidence in the literature to suggest that the intestinal microbiota and the gut-intestinal axis are important factors in the pathogenesis of IBS. Moreover, the literature findings have demonstrated beneficial effects of modifying the intestinal flora composition in alleviating IBS symptoms. Although the pathophysiology of IBS and the role of the intestinal microflora and gut-intestinal axis in it are well known, many issues are still to be elucidated. Further research into the bacteria identified in stool and colon mucosa of healthy individuals should provide more information on restoration of intestinal homeostasis in IBS patients.

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CHRONIC PELVIC PAIN

The Professional Medical Journal ◽

10.29309/tpmj/2018.25.02.438 ◽

2018 ◽

Vol 25 (02) ◽

pp. 173-179

Author(s):

Syeda Rabia ◽

Naeem Akhtar Qureshi ◽

Afsha Shahid ◽

Hira Afreen

Keyword(s):

Irritable Bowel Syndrome ◽

Pelvic Pain ◽

Chronic Pelvic Pain ◽

Depression Scale ◽

Anxiety And Depression ◽

P Value ◽

Standard Tool ◽

The Mean ◽

Irritable Bowel ◽

Associated Risk Factors

Objectives: To determine the frequency and associated risk factors of chronicpelvic pain (CPP) in educated women under 30 years of age. Study Design: A cross sectionalstudy. Setting: North Naziabad and Gulshan e Iqbal towns of Karachi. Period: January to July2017. Method: Data was collected through convenient sampling. Informed verbal consentwas taken before data collection. A questioner was used to collect demographic and obstetricdata. Screening of Anxiety and depression was done using standard tool Hospital basedanxiety and depression scale (HADS).Result were analyzed on SPSS. Result: The mean ageof women were 25 years, SD = 4.31. The frequency of chronic pelvic pain was 29% (116).Gynecological cause was found in 68.9% (80). Irritable bowel syndrome was seen in 9% (36)women. Significant association of CPP was noted with Dysmenorrhoea (p-value=000,OR=.207), Dyspareunia (p-value = .000, OR = .166), Heavy menstrual flow (p-value = .033, OR= .333), married (p-value = .000, OR = .414), Vaginal discharge (p-value = .000, OR = .260),Anxiety (p-value = .000, OR = .300), depression (p-value = .002, OR = .452), Normal mentalstatus (p-value = .000, OR = 2.488), Irritable bowel syndrome (p-value = .000, OR = .169)and PMS (p-value = .000, OR = .438). Conclusion: Frequency of chronic pelvic pain is high inyoung educated women. Gynecological causes, irritable bowel syndrome and psychologicaldisorder are significantly associated with CPP.

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