scholarly journals Role of STRO-1 sorting of porcine dental germ stem cells in dental stem cell-mediated bone tissue engineering

2017 ◽  
Vol 46 (3) ◽  
pp. 607-618 ◽  
Author(s):  
Gorke Gurel Pekozer ◽  
Mustafa Ramazanoglu ◽  
Karl Andreas Schlegel ◽  
Fatma Nese Kok ◽  
Gamze Torun Kose
2015 ◽  
Vol 3 (16) ◽  
pp. 3150-3168 ◽  
Author(s):  
Sunil Kumar Boda ◽  
Greeshma Thrivikraman ◽  
Bikramjit Basu

Substrate magnetization as a tool for modulating the osteogenesis of human mesenchymal stem cells for bone tissue engineering applications.


2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Azizeh-Mitra Yousefi ◽  
Paul F. James ◽  
Rosa Akbarzadeh ◽  
Aswati Subramanian ◽  
Conor Flavin ◽  
...  

Mesenchymal stem cells (MSCs) have been the subject of many studies in recent years, ranging from basic science that looks into MSCs properties to studies that aim for developing bioengineered tissues and organs. Adult bone marrow-derived mesenchymal stem cells (BM-MSCs) have been the focus of most studies due to the inherent potential of these cells to differentiate into various cell types. Although, the discovery of induced pluripotent stem cells (iPSCs) represents a paradigm shift in our understanding of cellular differentiation. These cells are another attractive stem cell source because of their ability to be reprogramed, allowing the generation of multiple cell types from a single cell. This paper briefly covers various types of stem cell sources that have been used for tissue engineering applications, with a focus on bone regeneration. Then, an overview of some recent studies making use of MSC-seeded 3D scaffold systems for bone tissue engineering has been presented. The emphasis has been placed on the reported scaffold properties that tend to improve MSCs adhesion, proliferation, and osteogenic differentiation outcomes.


2015 ◽  
Vol 49 (2) ◽  
pp. 51 ◽  
Author(s):  
Fatih Asutay ◽  
Ahmet Hüseyin Acar ◽  
Ümit Yolcu ◽  
Mustafa Kırtay ◽  
Hilal Alan

Biomaterials ◽  
2005 ◽  
Vol 26 (18) ◽  
pp. 3953-3960 ◽  
Author(s):  
Jui-Sheng Sun ◽  
Steven Yueh-Hsiu Wu ◽  
Feng-Huei Lin

2021 ◽  
Vol 22 (21) ◽  
pp. 11746
Author(s):  
Dušan Hollý ◽  
Martin Klein ◽  
Merita Mazreku ◽  
Radoslav Zamborský ◽  
Štefan Polák ◽  
...  

Oral and craniofacial bone defects caused by congenital disease or trauma are widespread. In the case of severe alveolar bone defect, autologous bone grafting has been considered a “gold standard”; however, the procedure has several disadvantages, including limited supply, resorption, donor site morbidity, deformity, infection, and bone graft rejection. In the last few decades, bone tissue engineering combined with stem cell-based therapy may represent a possible alternative to current bone augmentation techniques. The number of studies investigating different cell-based bone tissue engineering methods to reconstruct alveolar bone damage is rapidly rising. As an interdisciplinary field, bone tissue engineering combines the use of osteogenic cells (stem cells/progenitor cells), bioactive molecules, and biocompatible scaffolds, whereas stem cells play a pivotal role. Therefore, our work highlights the osteogenic potential of various dental tissue-derived stem cells and induced pluripotent stem cells (iPSCs), the progress in differentiation techniques of iPSCs into osteoprogenitor cells, and the efforts that have been made to fabricate the most suitable and biocompatible scaffold material with osteoinductive properties for successful bone graft generation. Moreover, we discuss the application of stem cell-derived exosomes as a compelling new form of “stem-cell free” therapy.


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