In present study, accurate, precise, rapid and sensitive stability indicting HPLC-UV
method has been established for quantification of Telmisartan, Cilnidipine and Chlorthalidone
simultaneously in Tablet and bulk. Telmisartan, Cilnidipine and Chlorthalidone were resoluted
on Sunsil C18 column (4.6mmx250mm; 5μm) using mobile phase containing Acetonitrile and
Potassium dihydrogen phosphate in 50:50(v/v) ratio with flow rate of 1ml/min at 238 nm.
Concentrations were linear over the range of 40-120 μg/ml for Telmisartan, 10-30 μg/ml for
Cilnidipine and 6.25-18.75 μg/ml for Chlorthalidone. The percentage recovery was found to be
99.70-100.51% for Telmisartan, 98.41-100.49% for Cilnidipine and 99.34-100.48% for
Chlorthalidone. % RSD for peak area was 0.069% for Telmisartan, 0.058% for Cilnidipine and
0.057% for Chlorthalidone shows that the proposed method is precise. Force-degradation
studies have not shown any observable change in the results and hence the proposed method is
stability indicating and hence the method is suitable for routine analysis of Telmisartan,
Cilnidipine and Chlorthalidone in bulk and tablet dosage form.