Human immunodeficiency virus type 1 compartmentalization in the central nervous system

2004 ◽  
Vol 10 (s1) ◽  
pp. 21-24 ◽  
Author(s):  
Carol K Petito
Keyword(s):  
Central Nervous System ◽  
Human Immunodeficiency Virus ◽  
Nervous System ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus ◽  
The Central Nervous System

scholarly journals Human immunodeficiency virus type 1 infection of the brain.

1993 ◽  
Vol 6 (4) ◽  
pp. 339-366 ◽  
Author(s):  
W J Atwood ◽  
J R Berger ◽  
R Kaderman ◽  
C S Tornatore ◽  
E O Major
Keyword(s):  
Central Nervous System ◽  
Human Immunodeficiency Virus ◽  
Nervous System ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Early Years ◽  
Immunodeficiency Virus ◽  
The Central Nervous System ◽  
Hiv 1

Direct infection of the central nervous system by human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, was not appreciated in the early years of the AIDS epidemic. Neurological complications associated with AIDS were largely attributed to opportunistic infections that arose as a result of the immunocompromised state of the patient and to depression. In 1985, several groups succeeded in isolating HIV-1 directly from brain tissue. Also that year, the viral genome was completely sequenced, and HIV-1 was found to belong to a neurotropic subfamily of retrovirus known as the Lentivirinae. These findings clearly indicated that direct HIV-1 infection of the central nervous system played a role in the development of AIDS-related neurological disease. This review summarizes the clinical manifestations of HIV-1 infection of the central nervous system and the related neuropathology, the tropism of HIV-1 for specific cell types both within and outside of the nervous system, the possible mechanisms by which HIV-1 damages the nervous system, and the current strategies for diagnosis and treatment of HIV-1-associated neuropathology.

scholarly journals Foscarnet Activity on Human Immunodeficiency Virus Type 1 in the Central Nervous System

1999 ◽  
Vol 28 (4) ◽  
pp. 931-931 ◽  
Author(s):  
Marie‐Luce Delforge ◽  
Claire‐Michèle Farber ◽  
Frédéric De Leener ◽  
Jean‐Marc Caroyer,Corinne Liesnard ◽  
Jean‐Paul Van Vooren
Keyword(s):  
Central Nervous System ◽  
Human Immunodeficiency Virus ◽  
Nervous System ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus ◽  
The Central Nervous System
Sign in / Sign up

Export Citation Format

Share Document