The Effects of Pressure-Sensitive Adhesives and Solubilizers on the Skin Permeation of Testosterone from a Matrix-Type Transdermal Delivery System

2002 ◽  
Vol 28 (9) ◽  
pp. 1125-1131 ◽  
Author(s):  
Hong Zhao ◽  
Dong-Woo Park ◽  
Soo-Kyun Kim ◽  
Chi-Ho Lee ◽  
Dae-Duk Kim
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Skin Permeation ◽  
Matrix Type ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive ◽  
Transdermal Delivery System

scholarly journals Synergic enhancing-effect of DEET and dodecylamine on the skin permeation of testosterone from a matrix-type transdermal delivery system

Drug Delivery ◽  
2009 ◽  
Vol 16 (5) ◽  
pp. 249-253 ◽  
Author(s):  
Hong Zhao ◽  
Min-Koo Choi ◽  
Jung Sun Kim ◽  
Chul-Soon Yong ◽  
Han-Gon Choi ◽  
...  
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Skin Permeation ◽  
Matrix Type ◽  
Enhancing Effect ◽  
Transdermal Delivery System

A TRANSDERMAL DRUG DELIVERY SYSTEM CONTAINING DEFERIOXAMINE MESYLATE FOR THE TREATMENT OF BETA-THALASSAEMIA MAJOR

2011 ◽  
Vol 23 (01) ◽  
pp. 29-35
Author(s):  
Chin-Hsiung Hsieh ◽  
Yuan-An Ku ◽  
Lien-Hua Chiu ◽  
Tai-Horng Young ◽  
Yi-You Huang
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Iron Overload ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Polysorbate 80 ◽  
Thalassaemia Major ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive

Patients with beta-thalassaemia major need blood transfusion frequently during their whole life. However, frequent transfusions will eventually lead to the accumulation of trivalent iron, resulting in iron overload. To reduce iron overload, patients are administered regularly with intravenous or subcutaneous infusion of deferioxamine mesylate (DFO). Nevertheless, high costs of medication, poor patient compliance, and side effects limit its use and patient's acceptance. To overcome such drawbacks, we developed a novel transdermal delivery system to administer the DFO instead of traditional injections. We assayed the feasibility of fabricating a transdermal DFO patch using the single-layer drug-in-adhesive drug delivery system. We used the pressure-sensitive adhesives and hydrogels as the drug reservoirs and studied the release profile of DFO from the transdermal patches in vitro. In order to enhance the transdermal delivery rate, chemical enhancers, polysorbate 80 and oleic acid, and physical enhancer, ultrasound, were incorporated into the monolith DFO patches. Experimental results showed that the combination of polysorbate 80 and oleic acid in the pressure-sensitive adhesives enhanced the penetration efficiency through nude mice skin. The pretreatment of nude mice skin with ultrasound temporally changed the diffusional resistance and facilitated DFO penetration through the skin. We expect that the new delivery system can enable the drug to penetrate through skin at a stable rate and reach the circulation system successfully, thus allowing the concentration of drug to achieve the therapeutic effect.

In Vitro and In Vivo Evaluation of a Novel Nonscrotal Matrix-Type Transdermal Delivery System of Testosterone

2005 ◽  
Vol 31 (3) ◽  
pp. 257-261 ◽  
Author(s):  
Hong Zhao ◽  
Chi-Ho Lee ◽  
Suk-Jae Chung ◽  
Chang-Koo Shim ◽  
Dae-Duk Kim
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
In Vivo Evaluation ◽  
Matrix Type ◽  
Transdermal Delivery System

In Vitro and In Vivo Evaluation of a Novel Nonscrotal Matrix-Type Transdermal Delivery System of Testosterone

2005 ◽  
Vol 31 (3) ◽  
pp. 257-261 ◽  
Author(s):  
Hong Zhao ◽  
Chi-Ho Lee ◽  
Suk-Jae Chung ◽  
Chang-Koo Shim ◽  
Dae-Duk Kim
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
In Vivo Evaluation ◽  
Matrix Type ◽  
Transdermal Delivery System

scholarly journals Pluronic lecithin organogel with d-limonene as a transdermal delivery system for Kaempferia parviflora extract

2018 ◽  
Vol 192 ◽  
pp. 01008
Author(s):  
Worranan Rangsimawong ◽  
Paisit Wattanasri ◽  
Prasert Akkaramongkolporn ◽  
Prasopchai Tonglairoum ◽  
Tanasait Ngawhirunpat ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Water Solubility ◽  
Skin Permeation ◽  
Storage Condition ◽  
Poloxamer 407 ◽  
Kaempferia Parviflora ◽  
Transdermal Delivery System

Kaempferia parviflora (KP) extract has been used in the Thai medicinal plant recipe, which the methoxyflavones are the main active compound. These compounds have low water solubility, high lipophilicity, and low bioavailability. The aim of this study was to develop the pluronic lecithin organogel (PLO) and PLO with d-limonene (PLO-L) for enhancing transdermal delivery of KP extract. These formulations were prepared and their physicochemical properties, stability, and in vitro skin permeation were evaluated. For the result, all formulations exhibited good physicochemical properties and stable under storage condition for 3 months. The permeation of KP extract-loaded PLO-L and PLO formulation showed significantly higher total methoxyflavones permeated through the skin than KP extract in water, which PLO-L provided the highest permeated flux of total methoxyflavones. This result suggested that d-limonene play a role as skin permeation enhancer. Organogel consisting of poloxamer 407 and lecithin also increased the skin permeation of KP extract. In conclusion, PLO-L could be a potential transdermal delivery system for KP extract.

A statistical approach to the development of a transdermal delivery system for ondansetron

2010 ◽  
Vol 399 (1-2) ◽  
pp. 87-93 ◽  
Author(s):  
Yasuko Obata ◽  
Yuriko Ashitaka ◽  
Shingo Kikuchi ◽  
Koichi Isowa ◽  
Kozo Takayama
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Statistical Approach ◽  
Transdermal Delivery System
Sign in / Sign up

Export Citation Format

Share Document