Inhibition of human macrophage colony formation by interleukin 4.
1989 ◽
Vol 170
(2)
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pp. 577-582
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Keyword(s):
We investigated the effects of human rIL-4 on in vitro hematopoiesis. A profound inhibition of macrophage colony formation by IL-4 was observed, whereas colony growth of other lineages was not affected. Inhibition of macrophage colony growth was not restricted to GM-CSF-induced colony growth but was also present in cultures stimulated with M-CSF. This inhibition was not only observed in cultures of light density bone marrow cells, but also in cultures of monocyte- and T lymphocyte-depleted bone marrow cells. Since a similar inhibition was observed in cultures of CD34+HLA-DR+-enriched bone marrow cells, a direct action of IL-4 on monocyte-committed progenitor cells is suggested.
1988 ◽
Vol 188
(6)
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pp. 405-409
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Keyword(s):
Keyword(s):
1968 ◽
Vol 46
(5)
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pp. 595-605
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Keyword(s):
1971 ◽
Vol 49
(6)
◽
pp. 595-603
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Keyword(s):
1987 ◽
Vol 166
(6)
◽
pp. 1851-1860
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Keyword(s):