scholarly journals A NOTE ON THE PROGRESS OF CICATRIZATION OF WAR WOUNDS

1918 ◽  
Vol 27 (2) ◽  
pp. 165-178
Author(s):  
Theodore Tuffler ◽  
R. Desmarres
Keyword(s):  
Epithelial Proliferation ◽  
Entire Surface ◽  
Chemical Substances ◽  
War Wounds ◽  
Arterial Circulation ◽  
Calculated Curve ◽  
Biologic Process ◽  
Scalp Wound ◽  
Lost Time ◽  
Organic Fluids

Some hypothetical conclusions bearing on the evolution of cicatricial tissue can be suggested. The arterial circulation deposits in the wound chemical substances necessary for contraction of the wound and for epithelial proliferation. When the biologic process is not hindered by any special or severe bacterial infection this deposit is as regular as the circulation itself, and enables us to determine in advance the date of cicatrization. It even seems as though when the epidermization process is retarded by a slight infection the substances necessary for epidermization are stored up in the wound, and when the delay due to infection is removed the epithelium finds an accumulation of nutritive substances, and, so to speak, makes up the lost time. Moreover, when an infection entirely or partially stops epidermization, we have observed (Experiments 3, 4, and 5) that after the infection has disappeared the progress of new epidermization is much more rapid than normally; it even passes the calculated curve. The infection apparently destroyed only the epithelium and left in the wound the chemical substances which activate epidermization. The existence of these physical or chemical activating agents has been indicated again by two anatomical clinical facts. In treating a scalp wound in which there had been practically no epidermization for many months, we applied over the entire surface of the sterile wound dermo-epidermic grafts of fetal skin. After apparently taking, the grafts were absorbed and disappeared, but epidermization of the periphery of the wound, which hitherto had not progressed, took place abundantly, almost a hundred times as much as before. We believe that by mathematical measurements we can solve the problem of the action of various organic fluids on the cicatrization of wounds.

Rotary Beveling for In Situ Thin-Section Microscopy of Cell Cultures

1981 ◽  
Vol 39 ◽  
pp. 550-551
Author(s):  
Dean A. Handley ◽  
Jack T. Alexander ◽  
Shu Chien
Keyword(s):  
Cell Growth ◽  
Cell Cultures ◽  
Molecular Interactions ◽  
Convenient Method ◽  
Petri Dish ◽  
Simple Method ◽  
Thin Section Microscopy ◽  
Thin Sectioning ◽  
Organic Fluids

In situ preparation of cell cultures for ultrastructural investigations is a convenient method by which fixation, dehydration and embedment are carried out in the culture petri dish. The in situ method offers the advantage of preserving the native orientation of cell-cell interactions, junctional regions and overlapping configurations. In order to section after embedment, the petri dish is usually separated from the polymerized resin by either differential cryo-contraction or solvation in organic fluids. The remaining resin block must be re-embedded before sectioning. Although removal of the petri dish may not disrupt the native cellular geometry, it does sacrifice what is now recognized as an important characteristic of cell growth: cell-substratum molecular interactions. To preserve the topographic cell-substratum relationship, we developed a simple method of tapered rotary beveling to reduce the petri dish thickness to a dimension suitable for direct thin sectioning.

1442: CXCL12 Over-Expression and Secretion by Aging Fibroblasts Stimulates Human Prostate Epithelial Proliferation in Vitro

2006 ◽  
Vol 175 (4S) ◽  
pp. 466-466
Author(s):  
Jill A. Macoska ◽  
Lesa Begley ◽  
Christine Monteleon ◽  
James W. MacDonald ◽  
Rajal B. Shah
Keyword(s):  
Human Prostate ◽  
Epithelial Proliferation ◽  
Over Expression ◽  
Proliferation In Vitro

Critical limb ischaemia in diabetes: definition, assessment, prognosis

VASA ◽  
2001 ◽  
Vol 30 (Supplement 58) ◽  
pp. 21-27
Author(s):  
Luther
Keyword(s):  
Diabetic Foot ◽  
Laboratory Tests ◽  
Critical Limb Ischaemia ◽  
Limb Ischaemia ◽  
Clinical Use ◽  
Arterial Reconstruction ◽  
Arterial Circulation ◽  
Diabetic Foot Disease ◽  
Foot Disease ◽  
Fontaine Classification

In diabetic foot disease, critical limb ischaemia (CLI) cannot be precisely described using established definitions. For clinical use, the Fontaine classification complemented with any objective verification of a reduced arterial circulation is sufficient for decision making. For scientific purposes, objective measurement criteria should be reported. Assessment of CLI should rely on the physical examination of the limb arteries, complemented by laboratory tests like the shape of the PVR curve at ankle or toe levels, and arteriography. The prognosis of CLI in diabetic foot disease depends on the success of arterial reconstruction. The best prognosis for the patients is with a preserved limb. Reconstructive surgery is the best choice for the majority of patients.

Ankle Brachial Pressure Index and compression application: Review summary

2019 ◽  
Vol 27 (2) ◽  
pp. 74-77
Author(s):  
Victoria Team ◽  
Georgina Gethin ◽  
John D Ivory ◽  
Kimberley Crawford ◽  
Ayoub Bouguettaya ◽  
...  
Keyword(s):  
Content Analysis ◽  
Clinical Practice ◽  
Venous Insufficiency ◽  
Arterial Disease ◽  
Leg Ulcers ◽  
Current Clinical Practice ◽  
Ankle Brachial Pressure Index ◽  
Arterial Circulation ◽  
Pressure Index ◽  
Peripheral Arterial

Venous leg ulcers (VLUs) are a significant complication amongst persons with chronic venous insufficiency (CVI) that frequently follow a cycle of healing and recurrence. Current clinical practice guidelines (CPGs) recommend applying below knee compression to improve VLU healing. Compression could be applied if the Ankle Brachial Pressure Index (ABPI) rules out significant arterial disease, as sufficient peripheral arterial circulation is necessary to ensure safe compression use. We conducted a content analysis of 13 global CPGs on the accuracy of recommendations related to ABPI and compression application. Eight CPGs indicated that compression is recommended when the ABPI is between 0.8 and 1.2 mmHg. However, this review found there is disagreement between 13 global VLU CPGs, with a lack of clarity on whether or not compression is indicated for patients with ABPIs between 0.6 and 0.8 mmHg. Some CPGs recommend reduced compression for treatment of VLUs, while others do not recommend any type of compression at all. This has implications for when it is safe to apply compression, and the inconsistency in evidence indicates that specialist advice may be required at levels beyond the ABPI “safe” range listed above.

Time Lost, Time Regained: Billy Wilder's The Private Life of Sherlock Holmes

2020 ◽  
Vol 1 (2) ◽  
pp. 189-202
Author(s):  
Laura Marcus
Keyword(s):  
Private Life ◽  
Sherlock Holmes ◽  
History Of ◽  
Part Structure ◽  
Lost Time

This article discusses Billy Wilder's 1970 film The Private Life of Sherlock Holmes, which, though not enthusiastically received by audiences at the time, has subsequently become a work highly valued by critics and cineastes. Radically cut from its original four-part structure by the studio, it has come to be perceived as a film about loss. This relates both to its themes – suppressed love, the vanished world of Holmes and Watson – and to the history of the film itself, whose missing episodes exist only in fragmentary form. The first part of the essay looks at the ways in which the film constructs an image of Sherlock Holmes (played by Robert Stephen), with a focus on the question of his sexuality, while the second part turns to the ways in which the film became an ‘obsession’ for one writer in particular, the novelist Jonathan Coe.

Metaphor's Lost Time: Notes on the New Translations of Proust

2005 ◽  
Vol 44 (2) ◽  
pp. 31-41 ◽  
Author(s):  
Michael O'Sullivan
Keyword(s):  
Lost Time
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