scholarly journals Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice

2007 ◽  
Vol 204 (9) ◽  
pp. i23-i23 ◽  
Author(s):  
Ping He ◽  
Zhenyu Zhong ◽  
Kristina Lindholm ◽  
Lilian Berning ◽  
Wendy Lee ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Learning And Memory ◽  
Tumor Necrosis ◽  
Death Receptor ◽  
Amyloid Β ◽  
Memory Deficits ◽  
Learning And Memory Deficits ◽  
Necrosis Factor

scholarly journals Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice

2007 ◽  
Vol 178 (5) ◽  
pp. 829-841 ◽  
Author(s):  
Ping He ◽  
Zhenyu Zhong ◽  
Kristina Lindholm ◽  
Lilian Berning ◽  
Wendy Lee ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Transgenic Mice ◽  
Learning And Memory ◽  
Tumor Necrosis ◽  
Death Receptor ◽  
Amyloid Β ◽  
Memory Deficits ◽  
Plaque Formation ◽  
App Processing ◽  
Necrosis Factor

The tumor necrosis factor type 1 death receptor (TNFR1) contributes to apoptosis. TNFR1, a subgroup of the TNFR superfamily, contains a cytoplasmic death domain. We recently demonstrated that the TNFR1 cascade is required for amyloid β protein (Aβ)–induced neuronal death. However, the function of TNFR1 in Aβ plaque pathology and amyloid precursor protein (APP) processing in Alzheimer's disease (AD) remains unclear. We report that the deletion of the TNFR1 gene in APP23 transgenic mice (APP23/TNFR1−/−) inhibits Aβ generation and diminishes Aβ plaque formation in the brain. Genetic deletion of TNFR1 leads to reduced β-secretase 1 (BACE1) levels and activity. TNFR1 regulates BACE1 promoter activity via the nuclear factor-κB pathway, and the deletion of TNFR1 in APP23 transgenic mice prevents learning and memory deficits. These findings suggest that TNFR1 not only contributes to neurodegeneration but also that it is involved in APP processing and Aβ plaque formation. Thus, TNFR1 is a novel therapeutic target for AD.

scholarly journals Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Induces Death Receptor 5 Networks That Are Highly Organized

2012 ◽  
Vol 287 (25) ◽  
pp. 21265-21278 ◽  
Author(s):  
Christopher C. Valley ◽  
Andrew K. Lewis ◽  
Deepti J. Mudaliar ◽  
Jason D. Perlmutter ◽  
Anthony R. Braun ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Necrosis Factor
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