scholarly journals Just how many holes…?

2020 ◽  
Vol 152 (11) ◽  
Author(s):  
Gyorgy Csordas ◽  
Stephen Hurst
Keyword(s):  
Permeability Transition ◽  
Permeability Transition Pores ◽  
Single Mitochondrion

Neginskaya et al. discuss the very low number of calcium-induced permeability transition pores in the single mitochondrion.

scholarly journals Determination of the Number of Permeability Transition Pores in Single Mitochondrion

2020 ◽  
Vol 118 (3) ◽  
pp. 446a
Author(s):  
Maria A. Neginskaya ◽  
Jasiel O. Strubbe ◽  
Giuseppe F. Amodeo ◽  
Jason N. Bazil ◽  
Evgeny V. Pavlov
Keyword(s):  
Permeability Transition ◽  
Permeability Transition Pores ◽  
Single Mitochondrion

scholarly journals Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity

2016 ◽  
Vol 473 (9) ◽  
pp. 1129-1140 ◽  
Author(s):  
Andrew P. Richardson ◽  
Andrew P. Halestrap
Keyword(s):  
Cell Death ◽  
Membrane Proteins ◽  
Mitochondrial Membrane ◽  
Mitochondrial Permeability Transition Pore ◽  
Mitochondrial Permeability Transition ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Mitochondrial Permeability ◽  
Molecular Identity ◽  
Permeability Transition Pores

The molecular identity of the mitochondrial permeability transition pore (MPTP), a key player in cell death, remains controversial. Here we use a novel MPTP inhibitor to demonstrate that formation of the pore involves native mitochondrial membrane proteins adopting novel conformations.

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