scholarly journals Characterization of Viral Agents Causing Acute Respiratory Infection in a San Francisco University Medical Center Clinic during the Influenza Season

2005 ◽  
Vol 41 (6) ◽  
pp. 822-828 ◽  
Author(s):  
J. K. Louie ◽  
J. K. Hacker ◽  
R. Gonzales ◽  
J. Mark ◽  
J. H. Maselli ◽  
...  
2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Liana Torosyan ◽  
Lilit Avetisyan ◽  
Artavazd Vanyan

ObjectiveThe goal of this study was to identify gaps in the severe acute respiratory infection sentinel surveillance system at Surb Astvatsamayr Medical Center.IntroductionInfluenza is a priority in Armenia. There are two influenza surveillance systems in Armenia: population and sentinel. The medical center (MC) has been included in sentinel surveillance since 2012. In 2015 a study was undertaken to identify gaps in severe acute respiratory infection (SARI) sentinel surveillance system in Surb Astvatsamayr MC.MethodsMedical records and reporting forms of SARI cases were generated for individuals meeting the case definition and analyzed for age groups, risk factors, sentinel surveillance detection methods, laboratory conformation, number of days hospitalized and reporting.ResultsIn 2014, 3016 patients were admitted in the hospital with ARI, of whom 2982 were younger than 18 years. During the 2014-2015 influenza season (week 40, 2014-week 20, 2015), 77 swabs have been taken in total, of which five were influenza positive (4 B and 1 AH1N1). Also in the 2013-2014 influenza season, five samples tested positive (all influenza A). Sixty-one (48%) patients with respiratory disease met the WHO SARI case definition (2011), 84 (66%) of all reviewed patients would have met the SARI case definition. The numbers for the ICU (25 records reviewed) do not reflect the actual percentage of patients admitted with respiratory symptoms. The 33 additional cases taken from the sampling logbook were mainly hospitalized in the ICU. Influenza tests were performed on 34 patients (mainly ICU), five were positive for influenza (four B--all adults—and one AH1N1), and four tested positives for other respiratory pathogens (two RSV, one RV, one BV). All influenza positives had fever or a history of fever and 80% met the WHO SARI case definition (2011). Non-sampled cases generally have fewer reported symptoms, but still 44% of cases fits the WHO SARI case definition (2011).ConclusionsThe percentages of patients meeting the WHO SARI 2011 case definition and the WHO SARI 2014 definition shows that mainly caused by the absence of shortness of breath in the SARI 2014 definition 52% (2011) vs 66% (2014) in Surb Asvatsamayr. A large number of children from Neonatal and Children’s departments fulfil the SARI case definition and could potentially be swabbed in addition to ICU patients. There are gaps in WHO SARI case definitions. The sentinel surveillance system should be improved.


2017 ◽  
Vol 24 (11) ◽  
pp. 1485-1498 ◽  
Author(s):  
Riley Bove ◽  
Tanuja Chitnis ◽  
Bruce AC Cree ◽  
Mar Tintoré ◽  
Yvonne Naegelin ◽  
...  

Background: There is a pressing need for robust longitudinal cohort studies in the modern treatment era of multiple sclerosis. Objective: Build a multiple sclerosis (MS) cohort repository to capture the variability of disability accumulation, as well as provide the depth of characterization (clinical, radiologic, genetic, biospecimens) required to adequately model and ultimately predict a patient’s course. Methods: Serially Unified Multicenter Multiple Sclerosis Investigation (SUMMIT) is an international multi-center, prospectively enrolled cohort with over a decade of comprehensive follow-up on more than 1000 patients from two large North American academic MS Centers (Brigham and Women’s Hospital (Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women’s Hospital (CLIMB; BWH)) and University of California, San Francisco (Expression/genomics, Proteomics, Imaging, and Clinical (EPIC))). It is bringing online more than 2500 patients from additional international MS Centers (Basel (Universitätsspital Basel (UHB)), VU University Medical Center MS Center Amsterdam (MSCA), Multiple Sclerosis Center of Catalonia-Vall d’Hebron Hospital (Barcelona clinically isolated syndrome (CIS) cohort), and American University of Beirut Medical Center (AUBMC-Multiple Sclerosis Interdisciplinary Research (AMIR)). Results and conclusion: We provide evidence for harmonization of two of the initial cohorts in terms of the characterization of demographics, disease, and treatment-related variables; demonstrate several proof-of-principle analyses examining genetic and radiologic predictors of disease progression; and discuss the steps involved in expanding SUMMIT into a repository accessible to the broader scientific community.


2019 ◽  
Vol 155 (91) ◽  
Author(s):  
Dylan Lucía Díaz-Chiguer ◽  
Rocío Tirado-Mendoza ◽  
Adrián Márquez-Navarro ◽  
Javier Rolando Ambrosio-Hernández ◽  
Ismael Ruiz-Fraga ◽  
...  

2014 ◽  
Vol 8 (4) ◽  
pp. 397-405 ◽  
Author(s):  
Richard K. Zimmerman ◽  
Charles R. Rinaldo ◽  
Mary Patricia Nowalk ◽  
Balasubramani GK ◽  
Mark G. Thompson ◽  
...  

2017 ◽  
Vol 16 (5) ◽  
pp. 33-42 ◽  
Author(s):  
N. P. Shmeleva ◽  
V. P. Shimanovich ◽  
N. V. Sivets ◽  
T. P. Lapo ◽  
N. V. Gribkova

Abstract estimation of anti-epidemic efficacy of a polymer-subunit vaccine Grippol® for large-scale immunization in adult work collectives and secondary schools in Vitebsk, Minsk and Grodno was conducted. Acute respiratory infection agents were detected by the means of RT-PCR in selected individuals. The overall number of participants was 12308 (5391 were children aged 6 - 17 and 6917 were 18 years or older). Influenza and ARI morbidity analysis demonstrates that Grippol® plus has a high anti-epidemic efficacy, reducing the influenza morbidity in the vaccinated cohort by 2.1 (adults) and 3.0 (children) times compared to that in unvaccinated persons. Efficacy and efficacy rate amounted to 50 3% and 2 2 in adults and 66 2% and 3 0 in children respectively A decrease in number of recurrent diseases complications in children was also demonstrated A dynamic morbidity analysis showed that in unvaccinated children there had been an evident increase in influenza and ARI among the unvaccinated children in late January - February 2016, while among the children who were vaccinated the morbidity rate was consistently low across all months of the influenza season.


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