Ten-Year Persistence of Antibody to Hepatitis B Surface Antigen in Healthcare Workers Vaccinated Against Hepatitis B Virus, and Response to Booster Vaccination

AbstractThis study estimated the number of HCWs with protective antibody levels 5 and 10 years after HBV vaccination. Kaplan-Meier probabilities of protective levels were 0.95 at 60 days after vaccination, 0.87 at 5 years, and 0.79 at 10 years. Those without protective levels displayed good response 7 and 30 days after a booster

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Hepatitis B Surface Antigen-Prevalence, Knowledge, Attitude and Vaccination Status among Healthcare Workers in a Tertiary Health Facility

Journal of BioMedical Research and Clinical Practice ◽

10.46912/jbrcp.174 ◽

2021 ◽

Vol 4 (2) ◽

pp. 37-46

Author(s):

DC Obu ◽

UV Asiegbu ◽

CT Ezeonu ◽

AFI Una ◽

CE Arua-Iduma ◽

...

Keyword(s):

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Surface Antigen ◽

Healthcare Workers ◽

Hepatitis B Surface Antigen ◽

Vaccination Status ◽

Hepatitis B Virus Infection ◽

Virus Vaccination ◽

B Virus

Healthcare workers (HCWs) are at increased risk of acquiring hepatitis virus B infection through occupational exposure. Having adequate knowledge and proper attitudes toward hepatitis B virus infection are crucial for its prevention. This study assessed the knowledge, attitude, and hepatitis B virus vaccination status of health care workers. A descriptive cross-sectional study among 120 healthcare workers that attended the World Hepatitis B-Day Celebration in June 2018 was undertaken. Data were obtained with a self-administered questionnaire on socio-demographic characteristics, knowledge, attitude towards HBV infection, and practice of hepatitis B vaccination. Commercial enzyme-linked immunosorbent assay kits were used to determine the prevalence of hepatitis B surface antigen. Data were analyzed using computer software SPSS version 22. The prevalence of HBsAg among the subjects was 4.5%. Only 53(47.7%) of the respondents had good knowledge of hepatitis B virus infection. The majority of respondents 91(82.0%) demonstrated a positive attitude towards hepatitis B virus infection and vaccination. Over 30% of respondents were aware of their hepatitis B virus infection status, and 29(26.1%) of them had received the hepatitis B virus vaccine. The major reason for the poor uptake of hepatitis B virus vaccination was not knowing where to get the vaccine in 40(57.1%) of them. Good knowledge of HBV infection had a statistically significant association with the age of respondents and their years of experience (p<0.05). It is recommended that a healthcare worker should be provided with more education and information on hepatitis B virus infection and vaccination. Also, hepatitis B screening and vaccination should be made mandatory as part of the pre-employment exercise of all healthcare workers with follow up screening before any upgrade or promotional examination exercise.

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Prevalence of Markers for Hepatitis B Virus and Vaccination Compliance Among Medical School Students in Italy

Infection Control and Hospital Epidemiology ◽

10.1086/592414 ◽

2008 ◽

Vol 29 (12) ◽

pp. 1189-1191 ◽

Cited By ~ 9

Author(s):

Andrea Trevisan ◽

Alberto Bruno ◽

Michele Mongillo ◽

Marta Morandin ◽

Anna Pantaleoni ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Medical School ◽

Surface Antigen ◽

Vaccination Coverage ◽

Hepatitis B Surface Antigen ◽

School Students ◽

Hbv Vaccination ◽

B Virus ◽

Low Rate

The prevalence of markers for hepatitis B virus (HBV) and the rate of compliance with HBV vaccination laws were investigated in a study at Padua University Medical School (Italy). Of 2,361 students, 385 (16.3%) tested negative for antibody to hepatitis B surface antigen. When vaccination was actively offered to these students, there was a low rate of compliance (47.0% [181 students]) but a good rate of seroconversion (93.1% [95 of 102 students]). Screening for HBV markers appears to be crucial to efforts to increase rates of vaccination coverage.

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Comparison of High-Throughput Fully Automated Immunoanalyzers for Detecting Hepatitis B Virus Infection

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2019-0096-oa ◽

2019 ◽

Vol 144 (5) ◽

pp. 612-619

Author(s):

Dongju Won ◽

Younhee Park ◽

Dasom Choi ◽

Hyon-Suk Kim

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Surface Antigen ◽

High Throughput ◽

Hepatitis B Surface Antigen ◽

B Virus ◽

Positive Rate ◽

Antibody Levels ◽

Hepatitis B Viral Infection ◽

Surface Antibody

Context.— High-throughput automated immunoanalyzers for hepatitis B virus serologic markers have been introduced but have not been compared to existing systems. Objective.— To compare hepatitis B surface antigen, hepatitis B surface antibody, and total hepatitis B core antibody analyses between our Architect i2000 platform and newer high-throughput fully automated immunoanalyzers. Design.— From May to June 2018, a total of 932, 914, and 1055 samples tested for hepatitis B surface antigen, hepatitis B surface antibody, and total hepatitis B core antibody, respectively, with the Architect i2000 system for routine testing in our center were tested again with Alinity i, Atellica IM, and Cobas e801 systems. Results.— Total concordance rates among the systems were 98.0%, 89.5%, and 93.0% for hepatitis B surface antigen, hepatitis B surface antibody, and total hepatitis B core antibody, respectively. Cohen's κ values exceeded 0.8. The correlations between serum hepatitis B surface antibody levels quantified by all 4 systems were high (r > 0.85). The hepatitis B surface antibody averages were greater for the Alinity i, Atellica IM, and Cobas e801 than for the Architect i2000 (P < .001). Conclusions.— Alinity i, Atellica IM, and Cobas e801 automated immunoanalyzers performed well when compared with the existing Architect i2000 system with regard to detection of hepatitis B viral infection. However, the new systems have higher titer and positivity rates for hepatitis B surface antibody and are more sensitive. Notably, the Atellica IM has a lower positive rate for total hepatitis B core antibody than does the Architect i2000.

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