scholarly journals Acute HIV Infections among Men with Genital Ulcer Disease in South Africa

2010 ◽  
Vol 201 (12) ◽  
pp. 1811-1815 ◽  
Author(s):  
G. Paz Bailey ◽  
M. Sternberg ◽  
D. A. Lewis ◽  
A. Puren
Keyword(s):  
South Africa ◽  
Hiv Infections ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Acute Hiv

scholarly journals Genital ulcer disease in women in Durban, South Africa.

1991 ◽  
Vol 67 (4) ◽  
pp. 322-326
Author(s):  
N O'Farrell ◽  
A A Hoosen ◽  
K D Coetzee ◽  
J van den Ende
Keyword(s):  
South Africa ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease

Human Immunodeficiency Virus Infection and Genital Ulcer Disease in South Africa

2000 ◽  
Vol 27 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Cheng Y. Chen ◽  
Ronald C. Ballard ◽  
Consuelo M. Beck-Sague ◽  
Yusuf Dangor ◽  
Frans Radebe ◽  
...  
Keyword(s):  
South Africa ◽  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Immunodeficiency Virus

scholarly journals Trends in the relative prevalence of genital ulcer disease pathogens and association with HIV infection in Johannesburg, South Africa, 2007–2015

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0194125 ◽  
Author(s):  
Ranmini S. Kularatne ◽  
Etienne E. Muller ◽  
Dumisile V. Maseko ◽  
Tendesayi Kufa-Chakezha ◽  
David A. Lewis
Keyword(s):  
South Africa ◽  
Hiv Infection ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Relative Prevalence

scholarly journals Correlates of bacterial ulcers and acute HSV-2 infection among men with genital ulcer disease in South Africa: age, recent sexual behaviours, and HIVi,ii

2016 ◽  
Vol 31 (2) ◽  
pp. 61-65
Author(s):  
Jami S. Leichliter ◽  
David A. Lewis
Keyword(s):  
South Africa ◽  
Chlamydia Trachomatis ◽  
Laboratory Tests ◽  
Treponema Pallidum ◽  
Haemophilus Ducreyi ◽  
Hiv Positive ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Sexual Behaviours ◽  
Acute Hiv

Data from baseline surveys and STI/HIV laboratory tests (n=615 men) were used to examine correlates of bacterial ulcers (Treponema pallidum, Haemophilus ducreyi, or Chlamydia trachomatis L1-L3 detected in ulcers) and acute HSV-2 ulcers (HSV-2 positive ulcer specimen, HSV-2 sero-negative, and negative for bacterial pathogens) versus recurrent HSV-2 ulcers (seropositive), separately. Men with bacterial ulcers had larger ulcers compared to men with recurrent HSV-2 ulcers, but were less likely to be HIV-positive; whereas, men with acute HSV-2 ulcers were younger with fewer partners. Acute HIV was higher among men with bacterial and acute HSV-2 ulcers; however, this difference was not statistically significant.

The changing epidemiology of genital ulcer disease in South Africa: has donovanosis been eliminated?

2020 ◽  
Vol 96 (8) ◽  
pp. 596-600
Author(s):  
Etienne E Muller ◽  
Ranmini Kularatne
Keyword(s):  
South Africa ◽  
Mononuclear Cells ◽  
Genital Ulcer ◽  
Nucleotide Sequencing ◽  
Surveillance Period ◽  
Screening Assay ◽  
Ulcer Disease ◽  
Sexually Transmitted ◽  
Genital Ulcer Disease ◽  
Restriction Digest

ObjectivesWe used an in-house molecular assay for the detection of Klebsiella granulomatis in ulcer specimens collected over a 12-year surveillance period in order to determine whether a diagnosis of donovanosis could be ascribed to genital ulcer disease (GUD) of unknown aetiology in our setting.MethodsBetween 2007 and 2018, a total of 974 genital ulcer specimens with no previously identified sexually transmitted (STI) pathogens were selected from STI aetiological surveys conducted in all nine provinces of South Africa. Giemsa-stained ulcer smears from the same participants had previously been routinely analysed for the presence of typical Donovan bodies within large mononuclear cells. A Klebsiella screening assay targeting the phoE (phosphate porin) gene was used in combination with restriction digest analysis and sequencing to confirm the presence of K. granulomatis.ResultsThe Klebsiella screening assay tested positive in 19/974 (2.0%) genital ulcer specimens. Restriction digest analysis and nucleotide sequencing of the phoE gene confirmed that none of these specimens was positive for K. granulomatis DNA. Similarly, Donovan bodies were not identified in the Giemsa stained ulcer smears of these specimens.ConclusionsThis is the first study to assess K. granulomatis as a cause of genital ulceration in South Africa over a 12-year surveillance period using molecular methods. The results demonstrate that K. granulomatis is no longer a prevalent cause of GUD in our population.

scholarly journals Genital ulcer disease in men in Durban, South Africa.

1991 ◽  
Vol 67 (4) ◽  
pp. 327-330 ◽  
Author(s):  
N O'Farrell ◽  
A A Hoosen ◽  
K D Coetzee ◽  
J van den Ende
Keyword(s):  
South Africa ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease
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