scholarly journals Correlates of bacterial ulcers and acute HSV-2 infection among men with genital ulcer disease in South Africa: age, recent sexual behaviours, and HIVi,ii

2016 ◽  
Vol 31 (2) ◽  
pp. 61-65
Author(s):  
Jami S. Leichliter ◽  
David A. Lewis
Keyword(s):  
South Africa ◽  
Chlamydia Trachomatis ◽  
Laboratory Tests ◽  
Treponema Pallidum ◽  
Haemophilus Ducreyi ◽  
Hiv Positive ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Sexual Behaviours ◽  
Acute Hiv

Data from baseline surveys and STI/HIV laboratory tests (n=615 men) were used to examine correlates of bacterial ulcers (Treponema pallidum, Haemophilus ducreyi, or Chlamydia trachomatis L1-L3 detected in ulcers) and acute HSV-2 ulcers (HSV-2 positive ulcer specimen, HSV-2 sero-negative, and negative for bacterial pathogens) versus recurrent HSV-2 ulcers (seropositive), separately. Men with bacterial ulcers had larger ulcers compared to men with recurrent HSV-2 ulcers, but were less likely to be HIV-positive; whereas, men with acute HSV-2 ulcers were younger with fewer partners. Acute HIV was higher among men with bacterial and acute HSV-2 ulcers; however, this difference was not statistically significant.

scholarly journals Acute HIV Infections among Men with Genital Ulcer Disease in South Africa

2010 ◽  
Vol 201 (12) ◽  
pp. 1811-1815 ◽  
Author(s):  
G. Paz Bailey ◽  
M. Sternberg ◽  
D. A. Lewis ◽  
A. Puren
Keyword(s):  
South Africa ◽  
Hiv Infections ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Acute Hiv

Etiology of Genital Ulcer Disease in Dakar, Senegal, and Comparison of PCR and Serologic Assays for Detection of Haemophilus ducreyi

2000 ◽  
Vol 38 (1) ◽  
pp. 268-273
Author(s):  
Patricia A. Totten ◽  
Jane M. Kuypers ◽  
Cheng-Yen Chen ◽  
Michelle J. Alfa ◽  
Linda M. Parsons ◽  
...  
Keyword(s):  
Transmitted Disease ◽  
Haemophilus Ducreyi ◽  
Genital Ulcer ◽  
Serological Tests ◽  
Past Infection ◽  
Ulcer Disease ◽  
Sexually Transmitted ◽  
Genital Ulcer Disease ◽  
Pcr Assays ◽  
Simplex Virus

ABSTRACT We used PCR assays to determine the etiology of genital ulcers in patients presenting to a sexually transmitted disease clinic in Dakar, Senegal, and evaluated the ability of two PCR tests ( groEL and recD ) and two serological tests (adsorption enzyme immunoassay [EIA] and lipooligosaccharide [LOS] EIA) to detect current Haemophilus ducreyi infection. We found that in this population, H. ducreyi , T. pallidum , and herpes simplex virus HSV DNA were detected in 56, 15, and 13% of 39 genital ulcer specimens, respectively, and H. ducreyi DNA was detected in 60% (3 of 5) of samples from ulcerated bubos. Among 40 consecutive patients with genital ulcer disease and with sufficient sample for both PCR assays, the recD and groEL H. ducreyi PCR assays were 83% concordant, with the recD PCR assay detecting six (15%) additional positive specimens and the groEL assay detecting one (3%) additional positive specimen. Compared to PCR, the adsorption EIA and LOS EIA tests had sensitivities of 71 and 59% and specificities of 57 and 90%, respectively, for the diagnosis of current H. ducreyi infection. While these differences in specificity could be due either to previous infection with H. ducreyi or to the detection of cross-reacting antibodies, only 6% of patients from a nearby family planning clinic gave a positive reaction in both the adsorption EIA and LOS EIA assays, indicating that cross-reacting antibodies are not prevalent among clinic attendees in this city. Our studies indicate that the adsorption EIA detects both current and past infection, while the LOS EIA assay is more specific for current infection with H. ducreyi in this population.

scholarly journals The Etiology of Genital Ulcer Disease and Coinfections With Chlamydia trachomatis and Neisseria gonorrhoeae in Zimbabwe

2018 ◽  
Vol 45 (1) ◽  
pp. 61-68 ◽  
Author(s):  
More Mungati ◽  
Anna Machiha ◽  
Owen Mugurungi ◽  
Mufuta Tshimanga ◽  
Peter H. Kilmarx ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Neisseria Gonorrhoeae ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease

scholarly journals Risk behaviours associated with urethritis and genital ulcer disease in prison inmates, Sindh, Pakistan

2002 ◽  
Vol 08 (06) ◽  
pp. 776-786 ◽  
Author(s):  
S. Akhtar ◽  
S. P. Luby
Keyword(s):  
Lifetime Risk ◽  
Genital Ulcer ◽  
Prison Inmates ◽  
Ulcer Disease ◽  
Factors Associated ◽  
Genital Ulcer Disease ◽  
Multiple Partners ◽  
Sexual Behaviours ◽  
Sex With Men ◽  
Male Prisoners

We evaluated the epidemiological differences with respect to demographics, drug use and sexual behaviours associated with lifetime risk of urethritis, genital ulcer disease [GUD] and urethritis and GUD together among 3395 male prisoners in Sindh. Factors associated with urethritis and GUD alone were sex with multiple females, sex with men, and ethnicity. Additional factors associated with urethritis alone were sex with prostitutes, sex with partners having multiple partners and sex with partners believed to be injecting drugs. Behaviours associated with lifetime risk for urethritis and GUD together were sex with multiple females, sex with prostitutes, sex with men, sex with partners believed to be injecting drugs and ethnicity. These relationships were consistently stronger compared to urethritis or GUD alone.

scholarly journals Protocolo Brasileiro para Infecções Sexualmente Transmissíveis 2020: infecções que causam úlcera genital

2021 ◽  
Vol 30 (spe1) ◽  
Author(s):  
Mauro Cunha Ramos ◽  
José Carlos Sardinha ◽  
Herculano Duarte Ramos de Alencar ◽  
Mayra Gonçalves Aragón ◽  
Leonor Henriette de Lannoy
Keyword(s):  
Chlamydia Trachomatis ◽  
Treponema Pallidum ◽  
Haemophilus Ducreyi

Resumo As infecções que causam úlcera genital são um dos temas que compõem o Protocolo Clínico e Diretrizes Terapêuticas para Atenção Integral às Pessoas com Infecções Sexualmente Transmissíveis, publicado pelo Ministério da Saúde do Brasil em 2020. Tal documento foi elaborado com base em evidências científicas e validado em discussões com especialistas. Este artigo aborda a síndrome clínica de úlcera genital causada por infecções sexualmente transmissíveis e seus agentes etiológicos mais comuns: Treponema pallidum (sífilis), vírus herpes simples 2 (herpes genital) e vírus herpes simples 1 (herpes perioral), Haemophilus ducreyi (cancroide), Chlamydia trachomatis sorotipos L1, L2 e L3 (linfogranuloma venéreo) e Klebsiella granulomatis (donovanose). São apresentados aspectos epidemiológicos e clínicos dessas infecções, bem como orientações para seu diagnóstico e tratamento, além de estratégias para as ações de vigilância, prevenção e controle, com a finalidade de subsidiar gestores e profissionais de saúde na qualificação da assistência.

Haemophilus Ducreyi

1993 ◽  
Vol 4 (6) ◽  
pp. 317-321 ◽  
Author(s):  
J A Jonasson
Keyword(s):  
Developing Countries ◽  
Risk Factor ◽  
Hiv Transmission ◽  
Haemophilus Ducreyi ◽  
Genital Ulcer ◽  
Industrialized Countries ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Fastidious Bacterium ◽  
Hygienic Conditions

Genital ulcer disease as a risk factor for HIV transmission has become apparent in the fight against AIDS. In poor communities in developing countries with people living under low hygienic conditions chancroid is often reported to be the most common form of genital ulcer. It is caused by Haemophilus ducreyi; a fastidious bacterium, notoriously difficult to grow in the laboratory. Apart from a few small micro-epidemics from time to time the disease, which has interesting immunological aspects, is now rare and almost forgotten in most industrialized countries. This may be part of the reason why there is no simple and inexpensive diagnostic test available yet that would be useful in the low-resource settings where chancroid is prevalent. The present review focuses on the diagnosis and pathogenesis of chancroid.

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