Harmonizing Longitudinal and Survival Data Using a Joint-Modeling Framework: An Efficient Approach to Assessing Social Interventions

2021 ◽  
pp. 000-000
Author(s):  
Ding-Geng Chen ◽  
David Ansong ◽  
Kanisha C. Brevard ◽  
Moses Okumu ◽  
Ai Bo
Keyword(s):  
Survival Data ◽  
Joint Modeling ◽  
Modeling Framework ◽  
Efficient Approach ◽  
Social Interventions ◽  
Longitudinal And Survival Data

scholarly journals Sample size and power determination in joint modeling of longitudinal and survival data

2011 ◽  
Vol 30 (18) ◽  
pp. 2295-2309 ◽  
Author(s):  
Liddy M. Chen ◽  
Joseph G. Ibrahim ◽  
Haitao Chu
Keyword(s):  
Sample Size ◽  
Survival Data ◽  
Joint Modeling ◽  
Longitudinal And Survival Data

scholarly journals Serum Lipids and Cardiovascular Disease Mortality in Iranian Population: Joint Modeling of Longitudinal and Survival Data in Tehran Lipid and Glucose Study (TLGS) Cohort

2019 ◽  
Vol 8 ◽  
pp. 1516
Author(s):  
Bagher Pahlavanzade ◽  
Farid Zayeri ◽  
Taban Baghfalaki ◽  
Farzad Hadaeg ◽  
Davood Khalili ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Survival Data ◽  
Hdl Cholesterol ◽  
Joint Modeling ◽  
Lipid Markers ◽  
Time Dependent Covariates ◽  
Longitudinal And Survival Data ◽  
Lipid Abnormalities ◽  
Cvd Mortality

Background: Lipid abnormalities are major risk factors of death from cardiovascular disease (CVD). As well as, lipid markers are time-dependent covariates that change with aging. Previous cohort studies have only investigated baseline measurements of lipid markers on CVD mortality. Materials and Methods: The study sample consisted of 4,148 individuals aged over 40 years. Total cholesterol (TC), LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C) were measured in five phases. A joint model analysis was used to investigate the association between each longitudinal lipid markers and CVD mortality in men, women and pooled sample. All analysis was performed using the survival and joint modeling packages in R 3.3.3. Results: Totally, 233 CVD deaths occurred during a median follow-up of 12.4 years. For men, CVD mortality increased by 28% (confidence interval [CI]: 14%,44%) for a 10% increased in TC. For women, CVD mortality increased by 43% (CI: 22%, 68%) and 21% (CI:7%, 37%) for 10 % increase in TC and LDL-C and decreased by ‌18% (CI:7%, 27%) for a 10% increase in HDL-C. Conclusion: Association of lipid ‎markers with CVD mortality is different in men and women, such that high levels of TC ‎and ‎LDL-C and low levels of HDL-C are risk factors of CVD mortality in women, but only TC is a risk ‎factor of CVD mortality in men. [GMJ.2019;8:e1516]

scholarly journals Basic Concepts and Methods for Joint Models of Longitudinal and Survival Data

2010 ◽  
Vol 28 (16) ◽  
pp. 2796-2801 ◽  
Author(s):  
Joseph G. Ibrahim ◽  
Haitao Chu ◽  
Liddy M. Chen
Keyword(s):  
Clinical Trials ◽  
Survival Data ◽  
Eastern Cooperative Oncology Group ◽  
Joint Modeling ◽  
Operating Characteristics ◽  
Joint Models ◽  
Free Survival ◽  
Introductory Overview ◽  
Longitudinal And Survival Data

Joint models for longitudinal and survival data are particularly relevant to many cancer clinical trials and observational studies in which longitudinal biomarkers (eg, circulating tumor cells, immune response to a vaccine, and quality-of-life measurements) may be highly associated with time to event, such as relapse-free survival or overall survival. In this article, we give an introductory overview on joint modeling and present a general discussion of a broad range of issues that arise in the design and analysis of clinical trials using joint models. To demonstrate our points throughout, we present an analysis from the Eastern Cooperative Oncology Group trial E1193, as well as examine some operating characteristics of joint models through simulation studies.

Bayesian Joint Modeling of Skew-Positive Longitudinal-Survival Data Using Birnbaum-Saunders Distribution

2020 ◽  
Author(s):  
Tohid Jafari-Koshki ◽  
Sayed Mohsen Hosseini ◽  
Shahram Arsang-Jang
Keyword(s):  
Survival Data ◽  
Real Data ◽  
Information Criterion ◽  
Joint Modeling ◽  
Multivariate Modeling ◽  
Joint Models ◽  
Wide Range ◽  
Longitudinal Part ◽  
Research Questions ◽  
Longitudinal And Survival Data

Background: There has been a great interest in joint modeling of longitudinal and survival data in recent two decades. Joint models have less restrictive assumptions in multivariate modeling and could address various research questions. This has led to their wide applications in practice. However, earlier models had normality assumption on the distribution in longitudinal part that is usually violated in real data. Hence, recent research have focused on circumventing this issue. Using various skewed distributions has been proposed and applied in the literature. Nevertheless, the flexibility of the proposed methods is limited especially when the data are skew positive. Methods: In this paper, we introduce the use of Birnbaum-Saunders (BS) distribution in joint modeling context. BS distribution is more flexible and could cover a wide range of skew, kurtotic or bimodal data. Results: We analyzed publicly available ddI/ddC data both with normal and BS distributions in Bayesian setting and compared their fit by Widely Applicable Information Criterion (WAIC). The joint BS model showed a better fit to the data. Conclusion: We introduced and applied BS distribution in joint modeling of longitudinal-survival data. Using multi-parameter distributions such as BS in Bayesian setting could improve the fit of models without limitations that arise in transformation of data from original scale. 

Joint Modeling of Longitudinal and Survival Data via a Common Frailty

Biometrics ◽  
2004 ◽  
Vol 60 (4) ◽  
pp. 892-899 ◽  
Author(s):  
Sarah J. Ratcliffe ◽  
Wensheng Guo ◽  
Thomas R. Ten Have
Keyword(s):  
Survival Data ◽  
Joint Modeling ◽  
Longitudinal And Survival Data
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