Magnetic Localization of the Origins of Self-sustained Oscillation in Squid Giant Axons

1993 ◽  
Vol 185 (2) ◽  
pp. 300-301 ◽  
Author(s):  
S. F. Lin ◽  
R. A. Abbas ◽  
J. P. Wikswo
Keyword(s):  
Sustained Oscillation ◽  
Giant Axons

Oscillatory Dynamics of P53 Network With Time Delays

2018 ◽  
Vol 21 (6) ◽  
pp. 411-419 ◽  
Author(s):  
Conghua Wang ◽  
Fang Yan ◽  
Yuan Zhang ◽  
Haihong Liu ◽  
Linghai Zhang
Keyword(s):  
Hopf Bifurcation ◽  
Cell Fate ◽  
Time Delays ◽  
Sustained Oscillation ◽  
Multiple Time ◽  
Cell Fate Decisions ◽  
Oscillatory Dynamics ◽  
Main Components ◽  
Parameter Values ◽  
P53 Network

Aims and Objective: A large number of experimental evidences report that the oscillatory dynamics of p53 would regulate the cell fate decisions. Moreover, multiple time delays are ubiquitous in gene expression which have been demonstrated to lead to important consequences on dynamics of genetic networks. Although delay-driven sustained oscillation in p53-based networks is commonplace, the precise roles of such delays during the processes are not completely known. Method: Herein, an integrated model with five basic components and two time delays for the network is developed. Using such time delays as the bifurcation parameter, the existence of Hopf bifurcation is given by analyzing the relevant characteristic equations. Moreover, the effects of such time delays are studied and the expression levels of the main components of the system are compared when taking different parameters and time delays. Result and Conclusion: The above theoretical results indicated that the transcriptional and translational delays can induce oscillation by undergoing a super-critical Hopf bifurcation. More interestingly, the length of these delays can control the amplitude and period of the oscillation. Furthermore, a certain range of model parameter values is essential for oscillation. Finally, we illustrated the main results in detail through numerical simulations.

Multicolor Fluorescent Polymeric Actuator with Self‐Sustained Oscillation Behavior

2021 ◽  
pp. 2000781
Author(s):  
Beibei Zhan ◽  
Shuxin Wei ◽  
Zhengfang Hu ◽  
Hao Liu ◽  
Huiyu Qiu ◽  
...  
Keyword(s):  
Sustained Oscillation

EFFECTS OF BOUNDARY-LAYER THICKNESS ON UNSTEADY FLOW CHARACTERISTICS INSIDE OPEN CAVITIES AT SUBSONIC AND TRANSONIC SPEEDS

2012 ◽  
Vol 19 ◽  
pp. 206-213
Author(s):  
DANG-GUO YANG ◽  
JIAN-QIANG LI ◽  
ZHAO-LIN FAN ◽  
XIN-FU LUO
Keyword(s):  
Boundary Layer ◽  
Unsteady Flow ◽  
Layer Thickness ◽  
Boundary Layer Thickness ◽  
Sound Pressure ◽  
Flow Characteristics ◽  
Open Cavity ◽  
Aerodynamic Noise ◽  
Sustained Oscillation ◽  
Cavity Depth

An experimental study was conducted in a 0.6m by 0.6m wind-tunnel to analyze effects of boundary-layer thickness on unsteady flow characteristics inside a rectangular open cavity at subsonic and transonic speeds. The sound pressure level (SPL) distributions at the centerline of the cavity floor and Sound pressure frequency spectrum (SPFS) characteristics on some measurement positions presented herein was obtained with cavity length-to-depth ratio (L/D) of 8 over Mach numbers (Ma) of 0.6 and 1.2 at a Reynolds numbers (Re) of 1.23 × 107 and 2.02 × 107 per meter under different boundary-layer thickness to cavity-depth ratios (δ/D). The experimental angle of attack, yawing and rolling angles were 0°. The results indicate that decrease in δ/D leads to severe flow separation and unsteady pressure fluctuation, which induces increase in SPL at same measurement points inside the cavity at Ma of 0.6. At Ma of 1.2, decrease in δ/D results in enhancing compressible waves. Generally, decrease in δ/D induces more flow self-sustained oscillation frequencies. It also makes severer aerodynamic noise inside the open cavity.

Preliminary observations on escape swimming and giant neurons in Aglantha digitale (Hydromedusae: Trachylina)

1980 ◽  
Vol 58 (4) ◽  
pp. 549-552 ◽  
Author(s):  
S. Donaldson ◽  
G. O. Mackie ◽  
A. Roberts
Keyword(s):  
Action Potentials ◽  
Giant Axon ◽  
Synaptic Delay ◽  
Giant Axons ◽  
A Value ◽  
Giant Synapses ◽  
Run Up

Aglantha can swim in two ways, one of which, fast swimming, is evoked by contact with predators and serves for escape. The response consists of two or three violent contractions of which the first propels the animal a distance equivalent to five body lengths. Peak velocities in the range 0.3–0.4 m s−1 were measured. Drag is reduced by contraction of the tentacles.Coordination of escape swimming and tentacle contraction is achieved by a system of giant axons. A giant axon runs down each tentacle; action potentials in these elements show a one-for-one correspondence with potentials recorded from a ring-shaped axon lying in the margin near the tentacle bases. The ring giant synapses with eight motor giants which run up the subumbrella innervating the swimming muscles.Conduction velocities in the giant axons may be as high as 4.0 m s−1 in the case of the largest (40 μm diameter) axons. A value of 1.6 ms was obtained for minimum synaptic delay between the ring and motor giant axons.

scholarly journals Activation-inactivation of potassium channels and development of the potassium-channel spike in internally perfused squid giant axons.

1981 ◽  
Vol 78 (1) ◽  
pp. 43-61 ◽  
Author(s):  
I Inoue
Keyword(s):  
Potassium Channels ◽  
Potassium Channel ◽  
Voltage Clamp ◽  
Time Constant ◽  
Equilibrium Potential ◽  
Giant Axons ◽  
Dependent Inactivation ◽  
Voltage Dependent ◽  
Time Courses ◽  
Calcium Permeability

A spike that is the result of calcium permeability through potassium channels was separated from the action potential is squid giant axons internally perfused with a 30 mM NaF solution and bathed in a 100 mM CaCl2 solution by blocking sodium channels with tetrodotoxin. Currents through potassium channels were studied under voltage clamp. The records showed a clear voltage-dependent inactivation of the currents. The inactivation was composed of at least two components; one relatively fast, having a time constant of 20--30 ms, and the other very slow, having a time constant of 5--10 s. Voltage clamp was carried out with a variety of salt compositions in both the internal and external solutions. A similar voltage-dependent inactivation, also composed of the two components, was recognized in all the current through potassium channels. Although the direction and intensity of current strongly depended on the salt composition of the solutions, the time-courses of these currents at corresponding voltages were very similar. These results strongly suggest that the inactivation of the currents in attributable to an essential, dynamic property of potassium channels themselves. Thus, the generation of a potassium-channel spike can be understood as an event that occurs when the equilibrium potential across the potassium channel becomes positive.

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