Patient-specific dosimetric endpoints based treatment plan quality control in radiotherapy

2015 ◽  
Vol 60 (21) ◽  
pp. 8213-8227 ◽  
Author(s):  
Ting Song ◽  
David Staub ◽  
Mingli Chen ◽  
Weiguo Lu ◽  
Zhen Tian ◽  
...  
2015 ◽  
Author(s):  
◽  
Lindsey Appenzoller Olsen

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Knowledge-based planning (KBP) has become a prominent area of research in radiation oncology in the last five years. The development of KBP aims to address the lack of systematic quality control and plan quality variability in radiotherapy treatment planning by providing achievable, patient-specific optimization objectives derived from a model trained with a cohort of previously treated, site-specific plans. This dissertation intended to develop, evaluate, and implement a knowledge-based planning system to reduce variability and improve radiotherapy treatment plan quality. The project aimed to 1) develop and validate an algorithm to train mathematical models that predict dose-volume histograms for organs at risk in radiotherapy planning, 2) implement the algorithm into a software application in order to transfer the technology into clinical practice, and 3) evaluate the impact of the software system (algorithm + application) on reducing variability and improving radiotherapy treatment plan quality through knowledge transfer. The presented work demonstrates that a KBP model is beneficial to radiotherapy planning. The developed models adequately describe what is dosimetrically achievable for patient specific anatomy and have proven useful in outlier detection for quality control of radiotherapy planning. The KBP paradigm has also demonstrated ability to improve treatment plan quality through benchmarking and transfer of knowledge between institutions.


2014 ◽  
Vol 41 (6Part11) ◽  
pp. 230-230
Author(s):  
T Song ◽  
Z Tian ◽  
X Jia ◽  
L Zhou ◽  
S Jiang ◽  
...  

2015 ◽  
Vol 16 (3) ◽  
pp. 339-350 ◽  
Author(s):  
Joseph M. Dewhurst ◽  
Matthew Lowe ◽  
Mark J. Hardy ◽  
Christopher J. Boylan ◽  
Philip Whitehurst ◽  
...  

2009 ◽  
Vol 36 (12) ◽  
pp. 5497-5505 ◽  
Author(s):  
Binbin Wu ◽  
Francesco Ricchetti ◽  
Giuseppe Sanguineti ◽  
Misha Kazhdan ◽  
Patricio Simari ◽  
...  

2021 ◽  
Author(s):  
Arkajyoti Roy ◽  
Reisa Widjaja ◽  
Min Wang ◽  
Dan Cutright ◽  
Mahesh Gopalakrishnan ◽  
...  

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Stefan Gerlach ◽  
Christoph Fürweger ◽  
Theresa Hofmann ◽  
Alexander Schlaefer

AbstractAlthough robotic radiosurgery offers a flexible arrangement of treatment beams, generating treatment plans is computationally challenging and a time consuming process for the planner. Furthermore, different clinical goals have to be considered during planning and generally different sets of beams correspond to different clinical goals. Typically, candidate beams sampled from a randomized heuristic form the basis for treatment planning. We propose a new approach to generate candidate beams based on deep learning using radiological features as well as the desired constraints. We demonstrate that candidate beams generated for specific clinical goals can improve treatment plan quality. Furthermore, we compare two approaches to include information about constraints in the prediction. Our results show that CNN generated beams can improve treatment plan quality for different clinical goals, increasing coverage from 91.2 to 96.8% for 3,000 candidate beams on average. When including the clinical goal in the training, coverage is improved by 1.1% points.


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