An automated method for measuring static pressure–volume curves of the respiratory system and its application in healthy lungs and after lung damage by oleic acid infusion

2007 ◽  
Vol 28 (3) ◽  
pp. 235-247 ◽  
Author(s):  
Y Zhao ◽  
S E Rees ◽  
S Kjærgaard ◽  
B W Smith ◽  
A Larsson ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Respiratory System ◽  
Static Pressure ◽  
Lung Damage ◽  
Acid Infusion ◽  
Automated Method

Reproduction of MIGET retention and excretion data using a simple mathematical model of gas exchange in lung damage caused by oleic acid infusion

2006 ◽  
Vol 101 (3) ◽  
pp. 826-832 ◽  
Author(s):  
S. E. Rees ◽  
S. Kjærgaard ◽  
S. Andreassen ◽  
G. Hedenstierna
Keyword(s):  
Oleic Acid ◽  
Standard Deviation ◽  
Simple Model ◽  
Gas Exchange ◽  
Dead Space ◽  
Good Description ◽  
Lung Damage ◽  
Acid Infusion ◽  
Dead Space Volume ◽  
Space Volume

The multiple inert-gas elimination technique (MIGET) is a complex mathematical model and experimental technique for understanding pulmonary gas exchange. Simpler mathematical models have been proposed that have a limited view compared with MIGET but may be applicable for use in clinical practice. This study examined the use of a simple model of gas exchange to describe MIGET retention and excretion data in seven pigs before and following lung damage caused by oleic acid infusion and subsequently at different levels of positive end-expiratory pressure. The simple model was found to give, on average, a good description of MIGET data, as evaluated by a χ2 test on the weighted residual sum of squares resulting from the model fit ( P > 0.2). Values of the simple model's parameters (dead-space volume, shunt, and the fraction of alveolar ventilation going to compartment 2) compared well with the similar MIGET parameters (dead-space volume, shunt, log of the standard deviation of the perfusion, log of the standard deveation of the ventilation), giving values of bias and standard deviation on the differences between dead-space volume and shunt of 0.002 ± 0.002 liter and 7.3 ± 2.1% (% of shunt value), respectively. Values of the fraction of alveolar ventilation going to compartment 2 correlated well with log of the standard deviation of the perfusion ( r2 = 0.86) and log of the standard deviation of the ventilation ( r2 = 0.92). These results indicate that this simple model provides a good description of lung pathology following oleic acid infusion. It remains to be seen whether physiologically valid values of the simple model parameters can be obtained from clinical experiments varying inspired oxygen fraction. If so, this may indicate a role for simple models in the clinical interpretation of gas exchange.

THE EFFECT OF HIGH FREQUENCY VENTILATION ON THE / PATTERN IN DOGS WITH OLEIC ACID LUNG DAMAGE

1982 ◽  
Vol 57 (3) ◽  
pp. A89-A89
Author(s):  
E. L. Owens ◽  
T. S. Lee ◽  
B. D. Wright ◽  
S. Jakobson
Keyword(s):  
Oleic Acid ◽  
High Frequency ◽  
Lung Damage ◽  
High Frequency Ventilation ◽  
Frequency Ventilation

HISTOLOGIC AND HEMODYNAMIC EFFECTS OF PROSTACYCLIN AND PROSTAGLANDIN E1 FOLLOWING OLEIC ACID INFUSION

1980 ◽  
Vol 8 (4) ◽  
pp. 229
Author(s):  
Gus J. Slotman ◽  
George W. Machiedo ◽  
Kenneth F. Casey ◽  
Michael J. Lyons
Keyword(s):  
Oleic Acid ◽  
Prostaglandin E1 ◽  
Hemodynamic Effects ◽  
Acid Infusion

Oleic Acid Lung Damage in Pigs

1982 ◽  
Vol 26 (2) ◽  
pp. 121-125 ◽  
Author(s):  
E. Haldén ◽  
U. Hedstrand ◽  
K. Torsner
Keyword(s):  
Oleic Acid ◽  
Lung Damage

Assessment of temporal changes in pulmonary edema with NMR imaging

1989 ◽  
Vol 66 (3) ◽  
pp. 1197-1208 ◽  
Author(s):  
D. M. Phillips ◽  
P. S. Allen ◽  
S. F. Man
Keyword(s):  
Relaxation Time ◽  
Oleic Acid ◽  
Pulmonary Edema ◽  
Signal Intensity ◽  
Transverse Relaxation Time ◽  
Lung Edema ◽  
Lung Water ◽  
Transverse Relaxation ◽  
Acid Infusion ◽  
Potential Applicability

Nuclear magnetic resonance imaging (NMRI) parameters [longitudinal relaxation time (T1), transverse relaxation time (T2), and signal intensity] acquired at a magnetic field of 2.35 T were validated with a study of nine different phantom gel solutions. This technique was then applied to study 13 anesthetized supine cats, among which 10 had lung edema induced by oleic acid (0.075 ml/kg); the result was compared with postmortem analyses of lung water. Three animals (series A) were imaged until the edema was first visualized in NMRI, usually 15–20 min after oleic acid infusion. Another seven animals (series B) were imaged over 4–5 h. As lung water increased, so did the signal intensity. When edema first appeared, T1, T2, and the volume of the edematous region within the slice in the upper lobes showed no gravity-dependent differences; this was confirmed by postmortem measurements (series A) of lung water. With time, gravity-dependent regions displayed greater volumes of edematous regions and greater T1 values (P less than 0.01), suggesting a continued accumulation of lung water. In comparison, nondependent regions displayed constant volumes of edematous region and lesser T1 values (P less than 0.01), suggesting an increased protein concentration but no change in lung water. This study suggests the potential applicability of NMRI parameters in the assessment of pulmonary edema.

Lung damage and pulmonary uptake of serotonin in intact dogs

1985 ◽  
Vol 58 (6) ◽  
pp. 1761-1766 ◽  
Author(s):  
C. A. Dawson ◽  
C. W. Christensen ◽  
D. A. Rickaby ◽  
J. H. Linehan ◽  
M. R. Johnston
Keyword(s):  
Oleic Acid ◽  
Endothelial Function ◽  
Glass Bead ◽  
Endothelial Damage ◽  
Lung Damage ◽  
Serotonin Uptake ◽  
Pulmonary Uptake ◽  
Endothelial Surface ◽  
Anesthetized Dogs ◽  
Extravascular Volume

We examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of [3H]serotonin and the extravascular volume accessible to [14C]antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin uptake by 53 and 61%, respectively, but no change was observed with oleic acid or dextran infusion. The extravascular volume accessible to the antipyrine was reduced by 77% after embolization and increased by 177 and approximately 44% after oleic acid and dextran infusion, respectively. The results suggest that when the perfused endothelial surface is sufficiently reduced, as with embolization, the uptake of trace doses of serotonin will be depressed. In addition, decreases in serotonin uptake in response to imipramine in this study and in response to certain endothelial toxins in other studies suggest that serotonin uptake can reveal certain kinds of changes in endothelial function. However, the lack of a response to oleic acid-induced damage in the present study suggests that serotonin uptake is not sensitive to all forms of endothelial damage.

Possible errors using esophageal balloon in determination of pressure-volume characteristics of the lung and thoracic cage

1959 ◽  
Vol 14 (4) ◽  
pp. 525-530 ◽  
Author(s):  
John H. Knowles ◽  
Suk Ki Hong ◽  
Hermann Rahn
Keyword(s):  
Respiratory System ◽  
Supine Position ◽  
Static Pressure ◽  
Thoracic Cage ◽  
Lung Volumes ◽  
Esophageal Balloon ◽  
Volume Characteristics

The static pressure-volume curves of the lung, thoracic cage and total respiratory system were studied in the sitting, supine, prone and knee-elbow position in four subjects. The lung and thoracic-cage pressures were measured with the aid of an esophageal balloon and recorded on a water manometer. The analysis of these various components suggests that in the supine position the esophageal balloon is compressed by the mediastinal content, giving rise to an artifact in the recording of the lung pressure. If this artifact is taken into consideration, it would appear that the effect of posture on the compliance of the lung is negligible. Lung pressures calculated for various lung volumes during active breathing are compared with static values recorded on a water manometer. Submitted on December 19, 1958

CHARACTERIZATION OF PULMONARY INJURY INDUCED BY OLEIC ACID INFUSION

1980 ◽  
pp. 302-307
Author(s):  
Harvey S. Borovetz ◽  
James J. Murphy ◽  
Geoffrey Levine ◽  
Robert F. Debski ◽  
Robert L. Peel ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Pulmonary Injury ◽  
Acid Infusion
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