With the discovery of the Higgs boson at around 125 GeV, a circular Higgs factory design with high luminosity [Formula: see text] is becoming more popular in the accelerator world. The CEPC project in China is one of them. Machine Detector Interface (MDI) is the key research area in electron–positron colliders, especially in CEPC; it is one of the criteria to measure the accelerator and detector design performance. Because of the limited space available in the designed tunnel, many equipment including magnets, beam diagnostic instruments, masks, vacuum pumps, and components of the detector must coexist in a very small region. In this paper, some important MDI issues will be reported for the Interaction Region (IR) design, e.g. the final doublet quadrupoles physics design parameters, beam-stay-clear region and beam pipe, synchrotron radiation power and critical energy are also calculated.